GO:0106274
JSON
NAD+-protein-arginine ADP-ribosyltransferase activity
Molecular Function
Definition (GO:0106274 GONUTS page)
Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
Secondary IDs
GO:0003956, GO:0106275
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity | related |
NAD(P)+:L-arginine ADP-D-ribosyltransferase activity | exact |
NADP+-protein-arginine ADP-ribosyltransferase activity | broad |
NAD(P)(+)--arginine ADP-ribosyltransferase activity | exact |
mono(ADP-ribosyl)transferase activity | broad |
NAD(+):L-arginine ADP-D-ribosyltransferase activity | exact |
protein-arginine ADP-ribosyltransferase activity | exact |
peptidyl-arginine ADP-ribosylation activity | exact |
ADP-ribosyltransferase activity | broad |
NAD(P)+-protein-arginine ADP-ribosyltransferase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q3UPF5 | 10090 | ZCCHV_MOUSE | GO:1990404 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.4.2.31 | |
InterPro | IPR000768 | NAD:arginine ADP-ribosyltransferase, ART |
InterPro | IPR016225 | NAD--protein ADP-ribosyltransferase Alt-like |
InterPro | IPR043662 | NAD-protein ADP-ribosyltransferase ModB-like |
InterPro | IPR043663 | NAD-protein ADP-ribosyltransferase ModA-like |
InterPro | IPR043935 | SidE, mono-ADP-ribosyltransferase domain |
MetaCyc | 2.4.2.31-RXN | |
RHEA | 19149 | |
Reactome | R-HSA-1972385 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:29965 | L-argininium residue |
has_participant | CHEBI | CHEBI:142554 | N(omega)-(ADP-D-ribosyl)-L-argininium(1-) residue |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0018120 | obsolete peptidyl-arginine ADP-ribosylation | consider GO:0106274 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0106274 based on ALL annotations
The top 100 of 652 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+-protein-arginine ADP-ribosyltransferase activity
|
9,441.05 | 100.00 | 20,648 | 20,648 |
NAD+-protein poly-ADP-ribosyltransferase activity
|
1,189.80 | 10.19 | 7,185 | 57,013 |
regulation of viral transcription
|
2,378.00 | 3.10 | 704 | 2,795 |
nucleotidyltransferase activity
|
96.87 | 1.03 | 19,915 | 1,940,928 |
kinesin complex
|
113.01 | 0.79 | 468 | 39,096 |
glycosyltransferase activity
|
61.45 | 0.65 | 20,323 | 3,122,630 |
phospholipase D activator activity
|
4,333.60 | 0.40 | 84 | 183 |
dendritic spine development
|
692.01 | 0.39 | 84 | 1,146 |
base-excision repair, AP site formation via deaminated base removal
|
52.81 | 0.34 | 184 | 32,894 |
apical protein localization
|
284.05 | 0.34 | 80 | 2,659 |
Totals | 78058 | 13791252 |
No co-occurrence statistics for GO:0106274 based on MANUAL annotations
The top 100 of 139 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+-protein-arginine ADP-ribosyltransferase activity
|
67,989.42 | 100.00 | 19 | 19 |
histone H3K56 deacetylase activity, NAD-dependent
|
59,490.74 | 35.00 | 7 | 8 |
ketone biosynthetic process
|
59,490.74 | 35.00 | 7 | 8 |
NAD-dependent protein demyristoylase activity
|
36,609.69 | 28.00 | 7 | 13 |
NAD-dependent protein depalmitoylase activity
|
36,609.69 | 28.00 | 7 | 13 |
DNA damage sensor activity
|
22,663.14 | 21.21 | 7 | 21 |
positive regulation of protein localization to chromatin
|
18,304.84 | 18.42 | 7 | 26 |
histone H3K18 deacetylase activity, NAD-dependent
|
17,626.89 | 17.95 | 7 | 27 |
TORC2 complex binding
|
16,997.35 | 17.50 | 7 | 28 |
histone H3K9 deacetylase activity, NAD-dependent
|
16,411.24 | 17.07 | 7 | 29 |
Totals | 455 | 43197 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Deleted | DEFINITION | Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. |
2022-11-22 | Added | DEFINITION | Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. |
2022-02-25 | Added | SECONDARY | GO:0106275 (NADP+-protein-arginine ADP-ribosyltransferase activity) |
2022-02-25 | Added | SECONDARY | GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity) |
2022-02-25 | Deleted | RELATION | is a GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity) |
2022-02-25 | Added | RELATION | is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity) |
2022-02-25 | Added | SYNONYM | NADP+-protein-arginine ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(+):L-arginine ADP-D-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | protein-arginine ADP-ribosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-05 | Added | TERM | NAD+-protein-arginine ADP-ribosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Deleted | DEFINITION | Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. |
2022-11-22 | Added | DEFINITION | Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. |
2022-02-25 | Added | SYNONYM | NADP+-protein-arginine ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(+):L-arginine ADP-D-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | protein-arginine ADP-ribosyltransferase activity |
2022-02-25 | Deleted | DEFINITION | Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. |
2022-02-25 | Added | DEFINITION | Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. |
2022-02-25 | Added | SYNONYM | mono(ADP-ribosyl)transferase activity |
2022-02-25 | Added | SYNONYM | NAD(P)(+)--arginine ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(P)+:L-arginine ADP-D-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | ADP-ribosyltransferase activity |
2022-02-25 | Added | SYNONYM | peptidyl-arginine ADP-ribosylation activity |
2020-07-05 | Added | DEFINITION | Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-25 | Deleted | RELATION | is a GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity) |
2022-02-25 | Added | RELATION | is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity) |
2020-07-05 | Added | RELATION | is a GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-25 | Added | XREF | MetaCyc:2.4.2.31-RXN |
2022-02-25 | Added | XREF | Reactome:R-HSA-1972385 |
2020-07-05 | Added | XREF | EC:2.4.2.31 |
2020-07-05 | Added | XREF | RHEA:19149 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-25 | Added | SECONDARY | GO:0106275 (NADP+-protein-arginine ADP-ribosyltransferase activity) |
2022-02-25 | Added | SECONDARY | GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link