This term is obsolete.

GO:0106274 JSON

NAD+-protein-arginine ADP-ribosyltransferase activity

Molecular Function

Definition (GO:0106274 GONUTS page)

Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.

Secondary IDs

GO:0003956, GO:0106275

20,960 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
NAD(P)+:L-arginine ADP-D-ribosyltransferase activity exact
NAD(P)(+)--arginine ADP-ribosyltransferase activity exact
mono(ADP-ribosyl)transferase activity broad
peptidyl-arginine ADP-ribosylation activity exact
ADP-ribosyltransferase activity broad
NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity related
NADP+-protein-arginine ADP-ribosyltransferase activity broad
NAD(P)+-protein-arginine ADP-ribosyltransferase activity broad
NAD(+):L-arginine ADP-D-ribosyltransferase activity exact
protein-arginine ADP-ribosyltransferase activity exact

Ancestor Chart

Ancestor chart for GO:0106274
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q3UPF5 10090 ZCCHV_MOUSE GO:1990404 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q6AYL7 10116 Q6AYL7_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7JRM5 7227 Q7JRM5_DROME GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.4.2.31
InterPro IPR000768 NAD:arginine ADP-ribosyltransferase, ART
InterPro IPR016225 NAD--protein ADP-ribosyltransferase Alt-like
InterPro IPR043662 NAD-protein ADP-ribosyltransferase ModB-like
InterPro IPR043663 NAD-protein ADP-ribosyltransferase ModA-like
InterPro IPR043935 SidE, mono-ADP-ribosyltransferase domain
MetaCyc 2.4.2.31-RXN
RHEA 19149
Reactome R-HSA-1972385

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:29965 L-argininium residue
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:142554 N(omega)-(ADP-D-ribosyl)-L-argininium(1-) residue
has_participant CHEBI CHEBI:17154 nicotinamide

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0018120 obsolete peptidyl-arginine ADP-ribosylation consider GO:0106274

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0106274 based on ALL annotations
The top 100 of 643 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0106274
NAD+-protein-arginine ADP-ribosyltransferase activity
9,466.15 100.00 20,933 20,933
GO:0003950
NAD+ poly-ADP-ribosyltransferase activity
1,176.82 10.10 7,321 58,889
GO:0046782
regulation of viral transcription
2,510.83 3.34 770 2,903
GO:0035821
modulation of process of another organism
333.74 3.01 3,603 102,195
GO:0090729
toxin activity
327.40 2.97 3,603 104,173
GO:0016779
nucleotidyltransferase activity
98.82 1.04 20,179 1,933,012
GO:0005871
kinesin complex
117.14 0.80 468 37,820
GO:0016757
glycosyltransferase activity
61.35 0.65 20,585 3,176,052
GO:1990583
phospholipase D activator activity
4,345.12 0.40 84 183
GO:0097510
base-excision repair, AP site formation via deaminated base removal
60.47 0.40 215 33,659
Totals 89717 13913368
No co-occurrence statistics for GO:0106274 based on MANUAL annotations
The top 100 of 139 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0106274
NAD+-protein-arginine ADP-ribosyltransferase activity
74,291.21 100.00 19 19
GO:0140765
histone H3K56 deacetylase activity, NAD-dependent
65,004.81 35.00 7 8
GO:0042181
ketone biosynthetic process
65,004.81 35.00 7 8
GO:0140773
NAD-dependent protein demyristoylase activity
40,002.96 28.00 7 13
GO:0140774
NAD-dependent protein depalmitoylase activity
40,002.96 28.00 7 13
GO:0140612
DNA damage sensor activity
24,763.74 21.21 7 21
GO:0120187
positive regulation of protein localization to chromatin
20,001.48 18.42 7 26
GO:1904841
TORC2 complex binding
18,572.80 17.50 7 28
GO:0003247
post-embryonic cardiac muscle cell growth involved in heart morphogenesis
74,291.21 15.79 3 3
GO:0050994
regulation of lipid catabolic process
15,295.25 15.22 7 34
Totals 448 38211

Change Log

Timestamp Action Category Detail
2022-11-22 Added DEFINITION Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
2022-11-22 Deleted DEFINITION Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
2022-02-25 Added XREF Reactome:R-HSA-1972385
2022-02-25 Added XREF MetaCyc:2.4.2.31-RXN
2022-02-25 Added SYNONYM NAD(P)(+)--arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM mono(ADP-ribosyl)transferase activity
2022-02-25 Added SYNONYM NADP+-protein-arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(P)+-protein-arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(+):L-arginine ADP-D-ribosyltransferase activity
2022-02-25 Added SYNONYM protein-arginine ADP-ribosyltransferase activity
Timestamp Action Category Detail
2020-07-05 Added TERM NAD+-protein-arginine ADP-ribosyltransferase activity
Timestamp Action Category Detail
2022-11-22 Added DEFINITION Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
2022-11-22 Deleted DEFINITION Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
2022-02-25 Added SYNONYM NAD(P)(+)--arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM mono(ADP-ribosyl)transferase activity
2022-02-25 Added SYNONYM NADP+-protein-arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(P)+-protein-arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(+):L-arginine ADP-D-ribosyltransferase activity
2022-02-25 Added SYNONYM protein-arginine ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM peptidyl-arginine ADP-ribosylation activity
2022-02-25 Added SYNONYM ADP-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity
2022-02-25 Added SYNONYM NAD(P)+:L-arginine ADP-D-ribosyltransferase activity
2022-02-25 Added DEFINITION Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide.
2022-02-25 Deleted DEFINITION Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
2020-07-05 Added DEFINITION Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.
Timestamp Action Category Detail
2022-02-25 Deleted RELATION is a GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity)
2022-02-25 Added RELATION is a GO:1990404 (NAD+-protein mono-ADP-ribosyltransferase activity)
2020-07-05 Added RELATION is a GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity)
Timestamp Action Category Detail
2022-02-25 Added XREF Reactome:R-HSA-1972385
2022-02-25 Added XREF MetaCyc:2.4.2.31-RXN
2020-07-05 Added XREF RHEA:19149
2020-07-05 Added XREF EC:2.4.2.31
Timestamp Action Category Detail
2022-02-25 Added SECONDARY GO:0106275 (NADP+-protein-arginine ADP-ribosyltransferase activity)
2022-02-25 Added SECONDARY GO:0003956 (NAD(P)+-protein-arginine ADP-ribosyltransferase activity)
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