This term is obsolete.

GO:0110078 JSON

TTT Hsp90 cochaperone complex

Cellular Component

Definition (GO:0110078 GONUTS page)

A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family. PMID:20810650 PMID:22505622 PMID:28827813 PMID:34233195

3,083 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
TTT complex exact
Tel2-Tti1-Tti2 exact
TELO2-TTI1-TTI2 exact
Triple T complex exact

Ancestor Chart

Ancestor chart for GO:0110078
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Ancestor chart

Cross-references

Database ID Description
InterPro IPR018870 Tti2 family

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0070209 obsolete ASTRA complex replaced_by GO:0110078

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0110078 based on ALL annotations
The top 100 of 208 co-occurring terms
Co-occurring Term PR S% #Together #Compared
TTT Hsp90 cochaperone complex
65,118.26 100.00 3,043 3,043
ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
6,856.56 5.90 360 3,419
CC tRNA cytidylyltransferase activity
6,852.55 5.90 360 3,421
positive regulation of DNA damage checkpoint
34,908.76 3.32 104 194
tRNA 3'-terminal CCA addition
1,080.05 1.48 363 21,886
regulation of TOR signaling
701.34 0.82 99 9,192
protein localization to chromosome
1,864.07 0.42 15 524
TORC1 complex
302.21 0.41 100 21,547
TORC2 complex
247.44 0.34 100 26,317
cellular response to salt stress
383.65 0.27 15 2,546
Totals 11769 46456219
No co-occurrence statistics for GO:0110078 based on MANUAL annotations
The top 50 of 50 co-occurring terms
Co-occurring Term PR S% #Together #Compared
TTT Hsp90 cochaperone complex
32,080.30 100.00 44 44
positive regulation of DNA damage checkpoint
16,983.69 17.31 9 17
'de novo' cotranslational protein folding
565.29 1.63 8 454
SLIK (SAGA-like) complex
1,688.44 1.61 1 19
regulation of TOR signaling
555.50 1.48 4 231
protein localization to chromosome
629.03 1.06 1 51
TORC1 complex
375.21 1.05 4 342
TORC2 complex
354.48 1.00 4 362
cellular response to salt stress
451.84 0.88 1 71
R2TP complex
196.81 0.54 2 326
Totals 205 888946

Change Log

Timestamp Action Category Detail
2023-09-23 Added SYNONYM TTT complex
2023-09-23 Deleted DEFINITION A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209).
2023-09-23 Updated TERM TTT Hsp90 cochaperone complex
2023-09-23 Added DEFINITION A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family.
2023-09-23 Deleted RELATION has part GO:0070209 (obsolete ASTRA complex)
2021-05-04 Deleted XREF IntAct:EBI-16631004
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-03 Added RELATION has part GO:0070209 (obsolete ASTRA complex)
2018-01-31 Added SYNONYM Triple T complex
Timestamp Action Category Detail
2023-09-23 Updated TERM TTT Hsp90 cochaperone complex
2018-01-31 Added TERM TTT complex
Timestamp Action Category Detail
2023-09-23 Added SYNONYM TTT complex
2023-09-23 Deleted DEFINITION A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209).
2023-09-23 Added DEFINITION A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family.
2018-01-31 Added SYNONYM Triple T complex
2018-01-31 Added SYNONYM Tel2-Tti1-Tti2
2018-01-31 Added SYNONYM TELO2-TTI1-TTI2
2018-01-31 Added DEFINITION A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209).
Timestamp Action Category Detail
2023-09-23 Deleted RELATION has part GO:0070209 (obsolete ASTRA complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-03 Added RELATION has part GO:0070209 (obsolete ASTRA complex)
2018-01-31 Added RELATION capable of part of GO:2000003 (positive regulation of DNA damage checkpoint)
2018-01-31 Added RELATION capable of part of GO:0050821 (protein stabilization)
2018-01-31 Added RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-16631004
2018-01-31 Added XREF IntAct:EBI-16631004
Timestamp Action Category Detail
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