"This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
GO:0120157
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PAR polarity complex
Cellular Component
Definition (GO:0120157 GONUTS page)
A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. PMID:11113154 PMID:18005931 PMID:22500799 PMID:28682236
Comments
"This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
PAR3-PAR6-atypical PKC | narrow |
BEM1-CDC24-CLA4 complex | narrow |
PAR6-PAR3-aPKC complex | narrow |
apical polarity complex | exact |
Cdc42p GEF-PAK complex | narrow |
PAR3/PAR6/aPKC | narrow |
Ancestor Chart
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0120157 based on ALL annotations
The top 100 of 284 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
PAR polarity complex
|
531,246.30 | 100.00 | 373 | 373 |
establishment of apical/basal cell polarity
|
142,763.84 | 15.85 | 104 | 387 |
negative regulation of glial cell apoptotic process
|
91,752.38 | 11.74 | 100 | 579 |
positive regulation of protein localization to centrosome
|
84,014.98 | 11.00 | 99 | 626 |
positive regulation of vacuole fusion, non-autophagic
|
392,110.34 | 8.07 | 31 | 42 |
positive regulation of glial cell proliferation
|
48,033.12 | 7.25 | 100 | 1,106 |
maintenance of protein location
|
110,527.75 | 6.31 | 31 | 149 |
cell morphogenesis involved in conjugation with cellular fusion
|
87,135.63 | 5.84 | 31 | 189 |
Schmidt-Lanterman incisure
|
36,491.97 | 5.72 | 95 | 1,383 |
GTP-dependent protein binding
|
32,950.72 | 5.28 | 98 | 1,580 |
Totals | 5239 | 885124 |
No co-occurrence statistics for GO:0120157 based on MANUAL annotations
The top 100 of 216 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
PAR polarity complex
|
94,102.20 | 100.00 | 15 | 15 |
branching involved in open tracheal system development
|
11,292.27 | 8.11 | 3 | 25 |
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
|
15,683.70 | 8.00 | 2 | 12 |
diacylglycerol-dependent serine/threonine kinase activity
|
8,065.90 | 6.38 | 3 | 35 |
negative regulation of sterol import
|
31,367.40 | 5.88 | 1 | 3 |
positive regulation of vacuole fusion, non-autophagic
|
31,367.40 | 5.88 | 1 | 3 |
cellular bud site selection
|
6,721.59 | 5.56 | 3 | 42 |
Cdc24p-Far1p-Gbetagamma complex
|
23,525.55 | 5.56 | 1 | 4 |
zonula adherens assembly
|
6,565.27 | 5.45 | 3 | 43 |
chemotropism
|
18,820.44 | 5.26 | 1 | 5 |
Totals | 199 | 9414 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | ComplexPortal:CPX-3462 |
2018-05-31 | Added | XREF | ComplexPortal:CPX-3462 |
2018-05-31 | Added | RELATION | capable of part of GO:0035023 (regulation of Rho protein signal transduction) |
2018-05-31 | Added | RELATION | is a GO:1902554 (serine/threonine protein kinase complex) |
2018-05-31 | Added | SYNONYM | PAR3/PAR6/aPKC |
2018-05-31 | Added | DEFINITION | A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. |
2018-05-31 | Added | SYNONYM | BEM1-CDC24-CLA4 complex |
2018-05-31 | Added | SYNONYM | PAR6-PAR3-aPKC complex |
2018-05-31 | Added | SYNONYM | Cdc42p GEF-PAK complex |
2018-05-31 | Added | SYNONYM | apical polarity complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Added | TERM | PAR polarity complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Added | SYNONYM | PAR3/PAR6/aPKC |
2018-05-31 | Added | DEFINITION | A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. |
2018-05-31 | Added | SYNONYM | BEM1-CDC24-CLA4 complex |
2018-05-31 | Added | SYNONYM | PAR6-PAR3-aPKC complex |
2018-05-31 | Added | SYNONYM | Cdc42p GEF-PAK complex |
2018-05-31 | Added | SYNONYM | apical polarity complex |
2018-05-31 | Added | SYNONYM | PAR3-PAR6-atypical PKC |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Added | RELATION | capable of part of GO:0035023 (regulation of Rho protein signal transduction) |
2018-05-31 | Added | RELATION | is a GO:1902554 (serine/threonine protein kinase complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | ComplexPortal:CPX-3462 |
2018-05-31 | Added | XREF | ComplexPortal:CPX-3462 |
Timestamp | Action | Category | Detail |
---|
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