This term is obsolete.
"This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.

GO:0120157 JSON

PAR polarity complex

Cellular Component

Definition (GO:0120157 GONUTS page)

A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. PMID:11113154 PMID:18005931 PMID:22500799 PMID:28682236

Comments

"This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.

377 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PAR3-PAR6-atypical PKC narrow
BEM1-CDC24-CLA4 complex narrow
PAR6-PAR3-aPKC complex narrow
apical polarity complex exact
Cdc42p GEF-PAK complex narrow
PAR3/PAR6/aPKC narrow

Ancestor Chart

Ancestor chart for GO:0120157
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0120157 based on ALL annotations
The top 100 of 284 co-occurring terms
Co-occurring Term PR S% #Together #Compared
PAR polarity complex
531,246.30 100.00 373 373
establishment of apical/basal cell polarity
142,763.84 15.85 104 387
negative regulation of glial cell apoptotic process
91,752.38 11.74 100 579
positive regulation of protein localization to centrosome
84,014.98 11.00 99 626
positive regulation of vacuole fusion, non-autophagic
392,110.34 8.07 31 42
positive regulation of glial cell proliferation
48,033.12 7.25 100 1,106
maintenance of protein location
110,527.75 6.31 31 149
cell morphogenesis involved in conjugation with cellular fusion
87,135.63 5.84 31 189
Schmidt-Lanterman incisure
36,491.97 5.72 95 1,383
GTP-dependent protein binding
32,950.72 5.28 98 1,580
Totals 5239 885124
No co-occurrence statistics for GO:0120157 based on MANUAL annotations
The top 100 of 216 co-occurring terms
Co-occurring Term PR S% #Together #Compared
PAR polarity complex
94,102.20 100.00 15 15
branching involved in open tracheal system development
11,292.27 8.11 3 25
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
15,683.70 8.00 2 12
diacylglycerol-dependent serine/threonine kinase activity
8,065.90 6.38 3 35
negative regulation of sterol import
31,367.40 5.88 1 3
positive regulation of vacuole fusion, non-autophagic
31,367.40 5.88 1 3
cellular bud site selection
6,721.59 5.56 3 42
Cdc24p-Far1p-Gbetagamma complex
23,525.55 5.56 1 4
zonula adherens assembly
6,565.27 5.45 3 43
chemotropism
18,820.44 5.26 1 5
Totals 199 9414

Change Log

Timestamp Action Category Detail
2021-05-04 Deleted XREF ComplexPortal:CPX-3462
2018-05-31 Added XREF ComplexPortal:CPX-3462
2018-05-31 Added RELATION capable of part of GO:0035023 (regulation of Rho protein signal transduction)
2018-05-31 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2018-05-31 Added SYNONYM PAR3/PAR6/aPKC
2018-05-31 Added DEFINITION A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.
2018-05-31 Added SYNONYM BEM1-CDC24-CLA4 complex
2018-05-31 Added SYNONYM PAR6-PAR3-aPKC complex
2018-05-31 Added SYNONYM Cdc42p GEF-PAK complex
2018-05-31 Added SYNONYM apical polarity complex
Timestamp Action Category Detail
2018-05-31 Added TERM PAR polarity complex
Timestamp Action Category Detail
2018-05-31 Added SYNONYM PAR3/PAR6/aPKC
2018-05-31 Added DEFINITION A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.
2018-05-31 Added SYNONYM BEM1-CDC24-CLA4 complex
2018-05-31 Added SYNONYM PAR6-PAR3-aPKC complex
2018-05-31 Added SYNONYM Cdc42p GEF-PAK complex
2018-05-31 Added SYNONYM apical polarity complex
2018-05-31 Added SYNONYM PAR3-PAR6-atypical PKC
Timestamp Action Category Detail
2018-05-31 Added RELATION capable of part of GO:0035023 (regulation of Rho protein signal transduction)
2018-05-31 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
Timestamp Action Category Detail
2021-05-04 Deleted XREF ComplexPortal:CPX-3462
2018-05-31 Added XREF ComplexPortal:CPX-3462
Timestamp Action Category Detail
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