GO:0120242
JSON
2-iminobutanoate deaminase activity
Molecular Function
Definition (GO:0120242 GONUTS page)
Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
2-iminobutanoate/2-iminopropanoate deaminase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | P38150 | 559292 | YB9Z_YEAST | GO:0019239 | InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013] | |
IEA Review | protein | P40361 | 559292 | YJH0_YEAST | GO:0019239 | InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013] | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
KEGG_REACTION | R11098 | |
MetaCyc | RXN-15123 | |
RHEA | 39975 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:28938 | ammonium |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:76545 | 2-iminobutanoic acid zwitterion |
has_participant | CHEBI | CHEBI:16763 | 2-oxobutanoate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0120242 based on ALL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-iminobutanoate deaminase activity
|
14,995,290.00 | 100.00 | 13 | 13 |
2-iminopropanoate deaminase activity
|
14,995,290.00 | 100.00 | 13 | 13 |
RNA endonuclease activity, producing 3'-phosphomonoesters
|
3,748,822.80 | 17.86 | 5 | 20 |
2-iminobutanoate/2-iminopropanoate deaminase
|
113,534.53 | 0.76 | 13 | 1,717 |
long-chain fatty acid binding
|
25,458.90 | 0.17 | 1 | 589 |
2-oxobutyrate biosynthetic process
|
22,893.57 | 0.15 | 2 | 1,310 |
response to salt
|
21,001.81 | 0.14 | 1 | 714 |
protein homotrimerization
|
11,232.43 | 0.07 | 1 | 1,335 |
G1 to G0 transition
|
9,099.09 | 0.06 | 1 | 1,648 |
mRNA destabilization
|
7,131.11 | 0.05 | 5 | 10,514 |
Totals | 184 | 130789463 |
No co-occurrence statistics for GO:0120242 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-iminobutanoate deaminase activity
|
215,299.84 | 100.00 | 6 | 6 |
2-oxobutyrate biosynthetic process
|
9,360.86 | 3.57 | 1 | 23 |
deaminase activity
|
2,563.09 | 1.18 | 3 | 252 |
protein homotrimerization
|
1,464.62 | 0.66 | 1 | 147 |
response to toxic substance
|
478.44 | 0.22 | 1 | 450 |
isoleucine biosynthetic process
|
285.92 | 0.13 | 1 | 753 |
protein-containing complex
|
54.19 | 0.03 | 1 | 3,973 |
unfolded protein binding
|
31.68 | 0.01 | 1 | 6,796 |
identical protein binding
|
24.52 | 0.01 | 1 | 8,780 |
cytosol
|
7.67 | 0.00 | 3 | 84,217 |
Totals | 20 | 166474 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-01 | Added | XREF | KEGG_REACTION:R11098 |
2020-08-01 | Added | XREF | RHEA:39975 |
2020-08-01 | Added | SYNONYM | 2-iminobutanoate/2-iminopropanoate deaminase |
2020-08-01 | Added | XREF | MetaCyc:RXN-15123 |
2020-08-01 | Added | TERM | 2-iminobutanoate deaminase activity |
2020-08-01 | Added | RELATION | is a GO:0120241 (2-iminobutanoate/2-iminopropanoate deaminase) |
2020-08-01 | Added | DEFINITION | Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-01 | Added | TERM | 2-iminobutanoate deaminase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-01 | Added | SYNONYM | 2-iminobutanoate/2-iminopropanoate deaminase |
2020-08-01 | Added | DEFINITION | Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-01 | Added | RELATION | is a GO:0120241 (2-iminobutanoate/2-iminopropanoate deaminase) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-01 | Added | XREF | KEGG_REACTION:R11098 |
2020-08-01 | Added | XREF | RHEA:39975 |
2020-08-01 | Added | XREF | MetaCyc:RXN-15123 |
Timestamp | Action | Category | Detail |
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