This term is obsolete.

GO:0120242 JSON

2-iminobutanoate deaminase activity

Molecular Function

Definition (GO:0120242 GONUTS page)

Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).

19 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
2-iminobutanoate/2-iminopropanoate deaminase broad

Ancestor Chart

Ancestor chart for GO:0120242
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P38150 559292 YB9Z_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
IEA Review protein P40361 559292 YJH0_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
KEGG_REACTION R11098
MetaCyc RXN-15123
RHEA 39975

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:76545 2-iminobutanoic acid zwitterion
has_participant CHEBI CHEBI:16763 2-oxobutanoate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0120242 based on ALL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-iminobutanoate deaminase activity
14,995,290.00 100.00 13 13
2-iminopropanoate deaminase activity
14,995,290.00 100.00 13 13
RNA endonuclease activity, producing 3'-phosphomonoesters
3,748,822.80 17.86 5 20
2-iminobutanoate/2-iminopropanoate deaminase
113,534.53 0.76 13 1,717
long-chain fatty acid binding
25,458.90 0.17 1 589
2-oxobutyrate biosynthetic process
22,893.57 0.15 2 1,310
response to salt
21,001.81 0.14 1 714
protein homotrimerization
11,232.43 0.07 1 1,335
G1 to G0 transition
9,099.09 0.06 1 1,648
mRNA destabilization
7,131.11 0.05 5 10,514
Totals 184 130789463
No co-occurrence statistics for GO:0120242 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-iminobutanoate deaminase activity
215,299.84 100.00 6 6
2-oxobutyrate biosynthetic process
9,360.86 3.57 1 23
deaminase activity
2,563.09 1.18 3 252
protein homotrimerization
1,464.62 0.66 1 147
response to toxic substance
478.44 0.22 1 450
isoleucine biosynthetic process
285.92 0.13 1 753
protein-containing complex
54.19 0.03 1 3,973
unfolded protein binding
31.68 0.01 1 6,796
identical protein binding
24.52 0.01 1 8,780
cytosol
7.67 0.00 3 84,217
Totals 20 166474

Change Log

Timestamp Action Category Detail
2020-08-01 Added XREF KEGG_REACTION:R11098
2020-08-01 Added XREF RHEA:39975
2020-08-01 Added SYNONYM 2-iminobutanoate/2-iminopropanoate deaminase
2020-08-01 Added XREF MetaCyc:RXN-15123
2020-08-01 Added TERM 2-iminobutanoate deaminase activity
2020-08-01 Added RELATION is a GO:0120241 (2-iminobutanoate/2-iminopropanoate deaminase)
2020-08-01 Added DEFINITION Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).
Timestamp Action Category Detail
2020-08-01 Added TERM 2-iminobutanoate deaminase activity
Timestamp Action Category Detail
2020-08-01 Added SYNONYM 2-iminobutanoate/2-iminopropanoate deaminase
2020-08-01 Added DEFINITION Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).
Timestamp Action Category Detail
2020-08-01 Added RELATION is a GO:0120241 (2-iminobutanoate/2-iminopropanoate deaminase)
Timestamp Action Category Detail
2020-08-01 Added XREF KEGG_REACTION:R11098
2020-08-01 Added XREF RHEA:39975
2020-08-01 Added XREF MetaCyc:RXN-15123
Timestamp Action Category Detail
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