This term is obsolete.

GO:0120516 JSON

diacylglycerol lipase activity

Molecular Function

Definition (GO:0120516 GONUTS page)

Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+.

888 annotations

Ancestor Chart

Ancestor chart for GO:0120516
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A078GW30 3708 A0A078GW30_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078IN56 3708 A0A078IN56_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078IW16 3708 A0A078IW16_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078J580 3708 A0A078J580_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A6JGS1 10116 A6JGS1_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B2RYW5 10116 B2RYW5_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZFS7 10116 D3ZFS7_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein M4DD04 3711 M4DD04_BRACM GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein M4EQ40 3711 M4EQ40_BRACM GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 3.1.1.79
MetaCyc RXN-19279
RHEA 32731

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17408 monoacylglycerol
has_participant CHEBI CHEBI:18035 diglyceride
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:28868 fatty acid anion
has_participant CHEBI CHEBI:15377 water

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0033878 obsolete hormone-sensitive lipase activity replaced_by GO:0120516
GO:0102258 obsolete 1,3-diacylglycerol acylhydrolase activity replaced_by GO:0120516
GO:0102259 obsolete 1,2-diacylglycerol acylhydrolase activity replaced_by GO:0120516

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0120516 based on ALL annotations
The top 100 of 163 co-occurring terms
Co-occurring Term PR S% #Together #Compared
diacylglycerol lipase activity
227,764.22 100.00 870 870
sterol ester esterase activity
21,640.72 9.16 625 6,578
negative regulation of smooth muscle cell migration
26,015.03 6.01 98 858
response to progesterone
15,174.83 4.52 107 1,606
smooth muscle cell migration
11,523.44 3.62 98 1,937
sperm plasma membrane
10,504.64 3.47 107 2,320
caveola
6,371.91 2.77 659 23,556
retinyl-palmitate esterase activity
7,329.05 2.43 78 2,424
triglyceride catabolic process
5,395.20 2.35 671 28,327
steroid hormone receptor signaling pathway
5,824.75 2.16 107 4,184
Totals 11331 52267381
No co-occurrence statistics for GO:0120516 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
diacylglycerol lipase activity
94,102.20 100.00 15 15
steroid hormone receptor signaling pathway
18,411.30 17.31 9 46
ether lipid metabolic process
17,109.49 14.29 6 33
sperm plasma membrane
12,198.43 11.29 7 54
nuclear steroid receptor activity
9,306.81 9.28 9 91
hormone binding
7,989.81 8.04 9 106
acylglycerol catabolic process
7,561.78 7.63 9 112
retinyl-palmitate esterase activity
7,734.43 7.32 6 73
acetylesterase activity
6,721.59 6.82 9 126
diacylglycerol catabolic process
5,535.42 5.41 6 102
Totals 251 707010

Change Log

Timestamp Action Category Detail
2024-06-30 Added XREF MetaCyc:RXN-19279
2024-06-30 Added XREF EC:3.1.1.79
2024-06-30 Added XREF RHEA:32731
2024-06-30 Added TERM diacylglycerol lipase activity
2024-06-30 Added DEFINITION Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+.
2024-06-30 Added RELATION is a GO:0016298 (lipase activity)
Timestamp Action Category Detail
2024-06-30 Added TERM diacylglycerol lipase activity
Timestamp Action Category Detail
2024-06-30 Added DEFINITION Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+.
Timestamp Action Category Detail
2024-06-30 Added RELATION is a GO:0016298 (lipase activity)
Timestamp Action Category Detail
2024-06-30 Added XREF MetaCyc:RXN-19279
2024-06-30 Added XREF EC:3.1.1.79
2024-06-30 Added XREF RHEA:32731
Timestamp Action Category Detail
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