GO:0120516
JSON
diacylglycerol lipase activity
Molecular Function
Definition (GO:0120516 GONUTS page)
Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+.
Ancestor Chart
Ancestor chart for GO:0120516
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A078GW30 | 3708 | A0A078GW30_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078IN56 | 3708 | A0A078IN56_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078IW16 | 3708 | A0A078IW16_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078J580 | 3708 | A0A078J580_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A6JGS1 | 10116 | A6JGS1_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B2RYW5 | 10116 | B2RYW5_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZFS7 | 10116 | D3ZFS7_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | M4DD04 | 3711 | M4DD04_BRACM | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | M4EQ40 | 3711 | M4EQ40_BRACM | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.1.79 | |
MetaCyc | RXN-19279 | |
RHEA | 32731 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17408 | monoacylglycerol |
has_participant | CHEBI | CHEBI:18035 | diglyceride |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:28868 | fatty acid anion |
has_participant | CHEBI | CHEBI:15377 | water |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0033878 | obsolete hormone-sensitive lipase activity | replaced_by GO:0120516 |
GO:0102258 | obsolete 1,3-diacylglycerol acylhydrolase activity | replaced_by GO:0120516 |
GO:0102259 | obsolete 1,2-diacylglycerol acylhydrolase activity | replaced_by GO:0120516 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0120516 based on ALL annotations
The top 100 of 163 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
diacylglycerol lipase activity
|
227,764.22 | 100.00 | 870 | 870 |
sterol ester esterase activity
|
21,640.72 | 9.16 | 625 | 6,578 |
negative regulation of smooth muscle cell migration
|
26,015.03 | 6.01 | 98 | 858 |
response to progesterone
|
15,174.83 | 4.52 | 107 | 1,606 |
smooth muscle cell migration
|
11,523.44 | 3.62 | 98 | 1,937 |
sperm plasma membrane
|
10,504.64 | 3.47 | 107 | 2,320 |
caveola
|
6,371.91 | 2.77 | 659 | 23,556 |
retinyl-palmitate esterase activity
|
7,329.05 | 2.43 | 78 | 2,424 |
triglyceride catabolic process
|
5,395.20 | 2.35 | 671 | 28,327 |
steroid hormone receptor signaling pathway
|
5,824.75 | 2.16 | 107 | 4,184 |
Totals | 11331 | 52267381 |
No co-occurrence statistics for GO:0120516 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
diacylglycerol lipase activity
|
94,102.20 | 100.00 | 15 | 15 |
steroid hormone receptor signaling pathway
|
18,411.30 | 17.31 | 9 | 46 |
ether lipid metabolic process
|
17,109.49 | 14.29 | 6 | 33 |
sperm plasma membrane
|
12,198.43 | 11.29 | 7 | 54 |
nuclear steroid receptor activity
|
9,306.81 | 9.28 | 9 | 91 |
hormone binding
|
7,989.81 | 8.04 | 9 | 106 |
acylglycerol catabolic process
|
7,561.78 | 7.63 | 9 | 112 |
retinyl-palmitate esterase activity
|
7,734.43 | 7.32 | 6 | 73 |
acetylesterase activity
|
6,721.59 | 6.82 | 9 | 126 |
diacylglycerol catabolic process
|
5,535.42 | 5.41 | 6 | 102 |
Totals | 251 | 707010 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-30 | Added | XREF | MetaCyc:RXN-19279 |
2024-06-30 | Added | XREF | EC:3.1.1.79 |
2024-06-30 | Added | XREF | RHEA:32731 |
2024-06-30 | Added | TERM | diacylglycerol lipase activity |
2024-06-30 | Added | DEFINITION | Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+. |
2024-06-30 | Added | RELATION | is a GO:0016298 (lipase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-30 | Added | TERM | diacylglycerol lipase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-30 | Added | DEFINITION | Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-30 | Added | RELATION | is a GO:0016298 (lipase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-30 | Added | XREF | MetaCyc:RXN-19279 |
2024-06-30 | Added | XREF | EC:3.1.1.79 |
2024-06-30 | Added | XREF | RHEA:32731 |
Timestamp | Action | Category | Detail |
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