This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.
GO:0140033
JSON
acetylation-dependent protein binding
Molecular Function
Definition (GO:0140033 GONUTS page)
Binding to a protein upon acetylation of the target protein. PMID:26060076
Comments
This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140033
Child Term | Relationship to GO:0140033 |
---|---|
lysine-acetylated histone binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140033 based on ALL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetylation-dependent protein binding
|
1,077,009.90 | 100.00 | 181 | 181 |
histone butyryltransferase activity
|
1,077,009.80 | 52.49 | 95 | 95 |
histone lactyltransferase (CoA-dependent) activity
|
888,533.10 | 49.01 | 99 | 120 |
behavioral defense response
|
757,895.80 | 42.99 | 95 | 135 |
positive regulation of T-helper 17 cell lineage commitment
|
403,878.70 | 37.42 | 180 | 480 |
protein propionyltransferase activity
|
549,608.10 | 35.87 | 99 | 194 |
histone H2B acetyltransferase activity
|
517,592.10 | 34.38 | 99 | 206 |
peptide butyryltransferase activity
|
363,904.34 | 26.40 | 99 | 293 |
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
|
264,575.62 | 20.41 | 99 | 403 |
swimming
|
228,894.70 | 17.82 | 95 | 447 |
Totals | 6727 | 707513 |
No co-occurrence statistics for GO:0140033 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetylation-dependent protein binding
|
117,436.27 | 100.00 | 11 | 11 |
histone H3K122 acetyltransferase activity
|
102,756.73 | 58.33 | 7 | 8 |
histone lactyltransferase (CoA-dependent) activity
|
102,756.73 | 58.33 | 7 | 8 |
negative regulation of miRNA metabolic process
|
117,436.28 | 54.55 | 6 | 6 |
histone H2B acetyltransferase activity
|
91,339.32 | 53.85 | 7 | 9 |
histone butyryltransferase activity
|
100,659.66 | 50.00 | 6 | 7 |
histone crotonyltransferase activity
|
82,205.39 | 50.00 | 7 | 10 |
protein propionyltransferase activity
|
74,732.17 | 46.67 | 7 | 11 |
peptide butyryltransferase activity
|
68,504.49 | 43.75 | 7 | 12 |
regulation of angiotensin metabolic process
|
70,461.77 | 40.00 | 6 | 10 |
Totals | 554 | 12855 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a protein upon acetylation of the target protein. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a protein upon acetylation of the target protein. |
2017-05-22 | Added | RELATION | is a GO:0140030 (modification-dependent protein binding) |
2017-05-22 | Added | TERM | acetylation-dependent protein binding |
2017-05-22 | Added | DEFINITION | Interacting selectively and non-covalently with a protein upon acetylation of the target protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-22 | Added | TERM | acetylation-dependent protein binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a protein upon acetylation of the target protein. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a protein upon acetylation of the target protein. |
2017-05-22 | Added | DEFINITION | Interacting selectively and non-covalently with a protein upon acetylation of the target protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-22 | Added | RELATION | is a GO:0140030 (modification-dependent protein binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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