This term is obsolete.
This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.

GO:0140033 JSON

acetylation-dependent protein binding

Molecular Function

Definition (GO:0140033 GONUTS page)

Binding to a protein upon acetylation of the target protein. PMID:26060076

Comments

This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term.

25,954 annotations

Ancestor Chart

Ancestor chart for GO:0140033
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140033

Child Term Relationship to
GO:0140033
lysine-acetylated histone binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140033 based on ALL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acetylation-dependent protein binding
1,077,009.90 100.00 181 181
histone butyryltransferase activity
1,077,009.80 52.49 95 95
histone lactyltransferase (CoA-dependent) activity
888,533.10 49.01 99 120
behavioral defense response
757,895.80 42.99 95 135
positive regulation of T-helper 17 cell lineage commitment
403,878.70 37.42 180 480
protein propionyltransferase activity
549,608.10 35.87 99 194
histone H2B acetyltransferase activity
517,592.10 34.38 99 206
peptide butyryltransferase activity
363,904.34 26.40 99 293
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
264,575.62 20.41 99 403
swimming
228,894.70 17.82 95 447
Totals 6727 707513
No co-occurrence statistics for GO:0140033 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acetylation-dependent protein binding
117,436.27 100.00 11 11
histone H3K122 acetyltransferase activity
102,756.73 58.33 7 8
histone lactyltransferase (CoA-dependent) activity
102,756.73 58.33 7 8
negative regulation of miRNA metabolic process
117,436.28 54.55 6 6
histone H2B acetyltransferase activity
91,339.32 53.85 7 9
histone butyryltransferase activity
100,659.66 50.00 6 7
histone crotonyltransferase activity
82,205.39 50.00 7 10
protein propionyltransferase activity
74,732.17 46.67 7 11
peptide butyryltransferase activity
68,504.49 43.75 7 12
regulation of angiotensin metabolic process
70,461.77 40.00 6 10
Totals 554 12855

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a protein upon acetylation of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon acetylation of the target protein.
2017-05-22 Added RELATION is a GO:0140030 (modification-dependent protein binding)
2017-05-22 Added TERM acetylation-dependent protein binding
2017-05-22 Added DEFINITION Interacting selectively and non-covalently with a protein upon acetylation of the target protein.
Timestamp Action Category Detail
2017-05-22 Added TERM acetylation-dependent protein binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a protein upon acetylation of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon acetylation of the target protein.
2017-05-22 Added DEFINITION Interacting selectively and non-covalently with a protein upon acetylation of the target protein.
Timestamp Action Category Detail
2017-05-22 Added RELATION is a GO:0140030 (modification-dependent protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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