This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
GO:0140035
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ubiquitin-like protein reader activity
Molecular Function
Definition (GO:0140035 GONUTS page)
A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. PMID:26060076
Comments
This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ubiquitination-like protein reader activity | exact |
ubiquitination-like modification-dependent protein binding | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140035
Child Term | Relationship to GO:0140035 |
---|---|
ubiquitin-modified protein reader activity
|
is_a |
UFM1-modified protein reader activity
|
is_a |
SUMO-modified protein reader activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140035 based on ALL annotations
The top 64 of 64 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ubiquitin-like protein reader activity
|
1,989,171.10 | 100.00 | 98 | 98 |
UFM1-modified protein reader activity
|
696,569.00 | 34.89 | 97 | 277 |
mitogen-activated protein kinase kinase kinase binding
|
110,131.06 | 5.53 | 97 | 1,752 |
histone reader activity
|
36,405.59 | 1.83 | 97 | 5,300 |
negative regulation of MAP kinase activity
|
74,593.92 | 1.71 | 3 | 80 |
symbiont defense to host-produced reactive oxygen species
|
397,834.25 | 0.98 | 1 | 5 |
postsynapse organization
|
15,698.08 | 0.72 | 7 | 887 |
DNA damage checkpoint signaling
|
4,678.13 | 0.24 | 97 | 41,245 |
cellular response to nitric oxide
|
5,510.17 | 0.22 | 1 | 361 |
protein phosphorylation
|
3,796.13 | 0.17 | 2 | 1,048 |
Totals | 1672 | 189637208 |
No co-occurrence statistics for GO:0140035 based on MANUAL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ubiquitin-like protein reader activity
|
161,474.88 | 100.00 | 8 | 8 |
UFM1-modified protein reader activity
|
51,378.37 | 30.43 | 7 | 22 |
proteasome-activating nucleotidase complex
|
40,368.72 | 9.09 | 1 | 4 |
symbiont defense to host-produced reactive oxygen species
|
32,294.98 | 8.33 | 1 | 5 |
postsynapse organization
|
13,271.91 | 8.00 | 6 | 73 |
mitogen-activated protein kinase kinase kinase binding
|
12,421.15 | 7.61 | 7 | 91 |
histone reader activity
|
9,341.52 | 5.74 | 7 | 121 |
symbiont-mediated perturbation of host defenses
|
11,533.92 | 4.76 | 1 | 14 |
response to nitrosative stress
|
5,568.10 | 2.78 | 1 | 29 |
protein modification process
|
3,220.30 | 1.99 | 7 | 351 |
Totals | 137 | 778205 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-26 | Deleted | DEFINITION | Binding to a protein upon modification by a ubiquitin-like protein of the target protein. |
2024-03-26 | Added | DEFINITION | A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. |
2024-03-26 | Added | SYNONYM | ubiquitination-like modification-dependent protein binding |
2024-03-26 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2024-03-26 | Added | SYNONYM | ubiquitination-like protein reader activity |
2024-03-26 | Updated | TERM | ubiquitin-like protein reader activity |
2021-05-24 | Added | DEFINITION | Binding to a protein upon modification by a ubiquitin-like protein of the target protein. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein. |
2017-05-22 | Added | DEFINITION | Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein. |
2017-05-22 | Added | TERM | ubiquitination-like modification-dependent protein binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-26 | Updated | TERM | ubiquitin-like protein reader activity |
2017-05-22 | Added | TERM | ubiquitination-like modification-dependent protein binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-26 | Deleted | DEFINITION | Binding to a protein upon modification by a ubiquitin-like protein of the target protein. |
2024-03-26 | Added | DEFINITION | A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. |
2024-03-26 | Added | SYNONYM | ubiquitination-like modification-dependent protein binding |
2024-03-26 | Added | SYNONYM | ubiquitination-like protein reader activity |
2021-05-24 | Added | DEFINITION | Binding to a protein upon modification by a ubiquitin-like protein of the target protein. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein. |
2017-05-22 | Added | DEFINITION | Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-26 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2017-05-22 | Added | RELATION | is a GO:0140030 (modification-dependent protein binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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