This term is obsolete.
This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.

GO:0140035 JSON

ubiquitin-like protein reader activity

Molecular Function

Definition (GO:0140035 GONUTS page)

A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. PMID:26060076

Comments

This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.

1,970 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ubiquitination-like protein reader activity exact
ubiquitination-like modification-dependent protein binding exact

Ancestor Chart

Ancestor chart for GO:0140035
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140035

Child Term Relationship to
GO:0140035
ubiquitin-modified protein reader activity
is_a
UFM1-modified protein reader activity
is_a
SUMO-modified protein reader activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140035 based on ALL annotations
The top 64 of 64 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein reader activity
1,989,171.10 100.00 98 98
UFM1-modified protein reader activity
696,569.00 34.89 97 277
mitogen-activated protein kinase kinase kinase binding
110,131.06 5.53 97 1,752
histone reader activity
36,405.59 1.83 97 5,300
negative regulation of MAP kinase activity
74,593.92 1.71 3 80
symbiont defense to host-produced reactive oxygen species
397,834.25 0.98 1 5
postsynapse organization
15,698.08 0.72 7 887
DNA damage checkpoint signaling
4,678.13 0.24 97 41,245
cellular response to nitric oxide
5,510.17 0.22 1 361
protein phosphorylation
3,796.13 0.17 2 1,048
Totals 1672 189637208
No co-occurrence statistics for GO:0140035 based on MANUAL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein reader activity
161,474.88 100.00 8 8
UFM1-modified protein reader activity
51,378.37 30.43 7 22
proteasome-activating nucleotidase complex
40,368.72 9.09 1 4
symbiont defense to host-produced reactive oxygen species
32,294.98 8.33 1 5
postsynapse organization
13,271.91 8.00 6 73
mitogen-activated protein kinase kinase kinase binding
12,421.15 7.61 7 91
histone reader activity
9,341.52 5.74 7 121
symbiont-mediated perturbation of host defenses
11,533.92 4.76 1 14
response to nitrosative stress
5,568.10 2.78 1 29
protein modification process
3,220.30 1.99 7 351
Totals 137 778205

Change Log

Timestamp Action Category Detail
2024-03-26 Deleted DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2024-03-26 Added DEFINITION A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
2024-03-26 Added SYNONYM ubiquitination-like modification-dependent protein binding
2024-03-26 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2024-03-26 Added SYNONYM ubiquitination-like protein reader activity
2024-03-26 Updated TERM ubiquitin-like protein reader activity
2021-05-24 Added DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
2017-05-22 Added DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
2017-05-22 Added TERM ubiquitination-like modification-dependent protein binding
Timestamp Action Category Detail
2024-03-26 Updated TERM ubiquitin-like protein reader activity
2017-05-22 Added TERM ubiquitination-like modification-dependent protein binding
Timestamp Action Category Detail
2024-03-26 Deleted DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2024-03-26 Added DEFINITION A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
2024-03-26 Added SYNONYM ubiquitination-like modification-dependent protein binding
2024-03-26 Added SYNONYM ubiquitination-like protein reader activity
2021-05-24 Added DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
2017-05-22 Added DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
Timestamp Action Category Detail
2024-03-26 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2017-05-22 Added RELATION is a GO:0140030 (modification-dependent protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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