This term is obsolete.
This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.

GO:0140035 JSON

ubiquitin-like protein reader activity

Molecular Function

Definition (GO:0140035 GONUTS page)

A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. PMID:26060076

Comments

This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.

1,966 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ubiquitination-like protein reader activity exact
ubiquitination-like modification-dependent protein binding exact

Ancestor Chart

Ancestor chart for GO:0140035
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140035

Child Term Relationship to
GO:0140035
UFM1-modified protein reader activity
is_a
SUMO-modified protein reader activity
is_a
ubiquitin-modified protein reader activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140035 based on ALL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein reader activity
2,042,833.60 100.00 97 97
UFM1-modified protein reader activity
710,550.80 34.66 96 276
mitogen-activated protein kinase kinase kinase binding
111,427.30 5.45 96 1,760
negative regulation of MAP kinase activity
77,575.96 1.73 3 79
histone reader activity
34,423.74 1.68 96 5,697
symbiont defense to host-produced reactive oxygen species
408,566.72 0.99 1 5
postsynapse organization
16,158.01 0.72 7 885
DNA damage checkpoint signaling
4,613.53 0.23 96 42,508
cellular response to nitric oxide
5,674.54 0.22 1 360
protein phosphorylation
4,017.37 0.18 2 1,017
Totals 1587 189885157
No co-occurrence statistics for GO:0140035 based on MANUAL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein reader activity
176,441.62 100.00 8 8
UFM1-modified protein reader activity
56,140.52 30.43 7 22
proteasome-activating nucleotidase complex
44,110.41 9.09 1 4
symbiont defense to host-produced reactive oxygen species
35,288.32 8.33 1 5
postsynapse organization
14,703.47 8.11 6 72
mitogen-activated protein kinase kinase kinase binding
13,280.55 7.45 7 93
histone reader activity
10,207.37 5.74 7 121
symbiont-mediated perturbation of host defenses
12,602.97 4.76 1 14
response to nitrosative stress
6,084.19 2.78 1 29
protein modification process
3,393.11 1.92 7 364
Totals 137 836545

Change Log

Timestamp Action Category Detail
2025-01-21 Deleted RELATION is a GO:0140030 (modification-dependent protein binding)
2024-03-26 Added SYNONYM ubiquitination-like modification-dependent protein binding
2024-03-26 Updated TERM ubiquitin-like protein reader activity
2024-03-26 Deleted DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2024-03-26 Added DEFINITION A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
2024-03-26 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2024-03-26 Added SYNONYM ubiquitination-like protein reader activity
2021-05-24 Added DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
2017-05-22 Added RELATION is a GO:0140030 (modification-dependent protein binding)
Timestamp Action Category Detail
2024-03-26 Updated TERM ubiquitin-like protein reader activity
2017-05-22 Added TERM ubiquitination-like modification-dependent protein binding
Timestamp Action Category Detail
2024-03-26 Added SYNONYM ubiquitination-like modification-dependent protein binding
2024-03-26 Deleted DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2024-03-26 Added DEFINITION A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.
2024-03-26 Added SYNONYM ubiquitination-like protein reader activity
2021-05-24 Added DEFINITION Binding to a protein upon modification by a ubiquitin-like protein of the target protein.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
2017-05-22 Added DEFINITION Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein.
Timestamp Action Category Detail
2025-01-21 Deleted RELATION is a GO:0140030 (modification-dependent protein binding)
2024-03-26 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2017-05-22 Added RELATION is a GO:0140030 (modification-dependent protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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