This term is obsolete.

GO:0140227 JSON

serotonin-gated cation-selective signaling pathway

Biological Process

Definition (GO:0140227 GONUTS page)

The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. PMID:25392484 PMID:27764665

369 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
5-HT-gated cation-selective signaling pathway exact
5-HT-gated cation-selective signalling pathway exact
serotonin-gated cation-selective signalling pathway exact
5-hydroxytryptamine-gated cation-selective signaling pathway exact
5-hydroxytryptamine-gated cation-selective signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0140227
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Ancestor chart

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0140227 serotonin-gated cation-selective signaling pathway Only in Taxon 33208 Metazoa

More information on taxon constraints in GO is available here

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140227 based on ALL annotations
The top 39 of 39 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serotonin-gated cation-selective signaling pathway
544,381.50 100.00 364 364
serotonin-activated cation-selective channel complex
542,890.06 99.73 364 365
serotonin-gated monoatomic cation channel activity
388,538.97 71.37 364 510
serotonin receptor signaling pathway
32,056.11 5.68 224 3,804
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
33,053.16 5.04 83 1,367
excitatory extracellular ligand-gated monoatomic ion channel activity
31,669.99 3.84 37 636
regulation of presynaptic membrane potential
22,445.93 3.62 83 2,013
serotonin binding
11,022.91 1.90 88 4,346
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
6,507.95 1.08 37 3,095
extracellular ligand-gated monoatomic ion channel activity
3,047.71 0.56 342 61,088
Totals 4692 80073406
No co-occurrence statistics for GO:0140227 based on MANUAL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serotonin-gated cation-selective signaling pathway
201,647.58 100.00 7 7
serotonin-activated cation-selective channel complex
156,837.00 77.78 7 9
serotonin receptor signaling pathway
8,933.75 4.43 7 158
serotonin-gated monoatomic cation channel activity
7,629.91 3.78 7 185
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
4,689.48 2.04 1 43
transmembrane transporter complex
2,673.36 1.33 7 528
serotonin binding
2,536.45 1.22 2 159
excitatory extracellular ligand-gated monoatomic ion channel activity
2,295.18 1.14 7 615
inorganic cation transmembrane transport
1,387.94 0.69 7 1,017
behavioral response to ethanol
1,390.67 0.66 1 145
Totals 121 236444

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2022-03-14 Added DEFINITION The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2021-05-04 Deleted XREF ComplexPortal:CPX-274
2021-05-04 Deleted XREF ComplexPortal:CPX-276
2021-05-04 Deleted XREF ComplexPortal:CPX-271
2021-05-04 Deleted XREF ComplexPortal:CPX-272
2021-05-04 Deleted XREF ComplexPortal:CPX-275
2021-05-04 Deleted XREF ComplexPortal:CPX-278
2021-05-04 Deleted XREF ComplexPortal:CPX-277
Timestamp Action Category Detail
2018-06-08 Added TERM serotonin-gated cation-selective signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2018-06-08 Added SYNONYM serotonin-gated cation-selective signalling pathway
2018-06-08 Added SYNONYM 5-HT-gated cation-selective signalling pathway
2018-06-08 Added SYNONYM 5-hydroxytryptamine-gated cation-selective signalling pathway
2018-06-08 Added SYNONYM 5-HT-gated cation-selective signaling pathway
2018-06-08 Added DEFINITION A series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
2018-06-08 Added SYNONYM 5-hydroxytryptamine-gated cation-selective signaling pathway
Timestamp Action Category Detail
2018-06-08 Added RELATION is a GO:0007210 (serotonin receptor signaling pathway)
2018-06-08 Added RELATION is a GO:1990806 (ligand-gated ion channel signaling pathway)
Timestamp Action Category Detail
2021-05-04 Deleted XREF ComplexPortal:CPX-274
2021-05-04 Deleted XREF ComplexPortal:CPX-276
2021-05-04 Deleted XREF ComplexPortal:CPX-271
2021-05-04 Deleted XREF ComplexPortal:CPX-272
2021-05-04 Deleted XREF ComplexPortal:CPX-275
2021-05-04 Deleted XREF ComplexPortal:CPX-278
2021-05-04 Deleted XREF ComplexPortal:CPX-277
2021-05-04 Deleted XREF ComplexPortal:CPX-273
2021-05-04 Deleted XREF ComplexPortal:CPX-2175
2018-06-08 Added XREF ComplexPortal:CPX-275
2018-06-08 Added XREF ComplexPortal:CPX-272
2018-06-08 Added XREF ComplexPortal:CPX-271
2018-06-08 Added XREF ComplexPortal:CPX-276
2018-06-08 Added XREF ComplexPortal:CPX-274
2018-06-08 Added XREF ComplexPortal:CPX-273
2018-06-08 Added XREF ComplexPortal:CPX-2175
2018-06-08 Added XREF ComplexPortal:CPX-277
2018-06-08 Added XREF ComplexPortal:CPX-278
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
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