This term is obsolete.

GO:0140292 JSON

ADP-ribosylserine hydrolase activity

Molecular Function

Definition (GO:0140292 GONUTS page)

Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose. PMID:28650317 PMID:29234005

125 annotations

Ancestor Chart

Ancestor chart for GO:0140292
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q93Y07 3702 SFR2_ARATH GO:0016798 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25100720

Cross-references

Database ID Description
RHEA 58256

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57967 ADP-D-ribose(2-)
has_participant CHEBI CHEBI:29999 L-serine residue
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:142556 O-(ADP-D-ribosyl)-L-serine(2-) residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140292 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ADP-ribosylserine hydrolase activity
1,756,205.20 100.00 111 111
peptidyl-serine ADP-deribosylation
1,756,205.40 89.19 99 99
cellular response to superoxide
1,602,750.40 78.33 94 103
negative regulation of necroptotic process
70,832.40 4.01 97 2,405
O-acetyl-ADP-ribose deacetylase activity
43,593.75 2.47 98 3,948
female germ-line stem cell population maintenance
53,513.18 2.39 11 361
poly(ADP-ribose) glycohydrolase activity
35,488.58 2.02 111 5,493
site of DNA damage
33,442.76 1.90 109 5,724
ADP-D-ribose binding
14,395.13 0.43 1 122
Cajal body organization
7,493.51 0.41 11 2,578
Totals 1942 141455159
No co-occurrence statistics for GO:0140292 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ADP-ribosylserine hydrolase activity
129,179.90 100.00 10 10
peptidyl-serine ADP-deribosylation
114,826.58 72.73 8 9
O-acetyl-ADP-ribose deacetylase activity
41,337.57 29.63 8 25
cellular response to superoxide
43,059.97 22.22 4 12
negative regulation of necroptotic process
10,033.39 7.62 8 103
poly(ADP-ribose) glycohydrolase activity
8,970.83 6.94 10 144
ADP-D-ribose binding
9,936.92 4.55 1 13
site of DNA damage
4,506.28 3.47 9 258
female germ-line stem cell population maintenance
2,748.51 1.79 1 47
hydrolase activity, hydrolyzing O-glycosyl compounds
2,227.24 1.72 8 464
Totals 120 503956

Change Log

Timestamp Action Category Detail
2024-07-13 Added XREF RHEA:58256
2023-06-24 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2018-11-25 Added DEFINITION Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.
2018-11-25 Added TERM ADP-ribosylserine hydrolase activity
2018-11-25 Added RELATION is a GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds)
Timestamp Action Category Detail
2018-11-25 Added TERM ADP-ribosylserine hydrolase activity
Timestamp Action Category Detail
2018-11-25 Added DEFINITION Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose.
Timestamp Action Category Detail
2023-06-24 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2018-11-25 Added RELATION is a GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds)
Timestamp Action Category Detail
2024-07-13 Added XREF RHEA:58256
Timestamp Action Category Detail
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