GO:0140294
JSON
NAD DNA ADP-ribosyltransferase activity
Molecular Function
Definition (GO:0140294 GONUTS page)
Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. PMID:27471034 PMID:29361132 PMID:29520010
Ancestor Chart
Ancestor chart for GO:0140294
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140294
| Child Term | Relationship to GO:0140294 |
|---|---|
|
2'-deoxyguanosine DNA ADP-ribosyltransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
| NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
| NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
| NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140294 based on ALL annotations
The top 100 of 134 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
NAD DNA ADP-ribosyltransferase activity
|
744,943.10 | 100.00 | 266 | 266 |
|
DNA ADP-ribosylation
|
607,837.00 | 81.60 | 266 | 326 |
|
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
|
744,943.06 | 36.47 | 97 | 97 |
|
NAD+-histone H3S10 serine ADP-ribosyltransferase activity
|
744,943.06 | 36.47 | 97 | 97 |
|
regulation of base-excision repair
|
744,943.06 | 36.47 | 97 | 97 |
|
negative regulation of isotype switching
|
744,943.06 | 31.58 | 84 | 84 |
|
NAD+-protein-serine ADP-ribosyltransferase activity
|
229,509.14 | 26.80 | 179 | 581 |
|
protein auto-ADP-ribosylation
|
198,751.11 | 26.68 | 266 | 997 |
|
negative regulation of ATP biosynthetic process
|
366,799.38 | 26.50 | 97 | 197 |
|
positive regulation of single strand break repair
|
347,401.34 | 25.73 | 97 | 208 |
| Totals | 8976 | 6272321 | ||
No co-occurrence statistics for GO:0140294 based on MANUAL annotations
The top 100 of 126 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
NAD DNA ADP-ribosyltransferase activity
|
108,579.45 | 100.00 | 13 | 13 |
|
DNA ADP-ribosylation
|
61,371.00 | 56.52 | 13 | 23 |
|
NAD+-protein-glutamate ADP-ribosyltransferase activity
|
59,225.16 | 52.17 | 12 | 22 |
|
negative regulation of isotype switching
|
108,579.46 | 38.46 | 5 | 5 |
|
NAD+-protein-serine ADP-ribosyltransferase activity
|
54,289.73 | 38.10 | 8 | 16 |
|
NAD+-protein-aspartate ADP-ribosyltransferase activity
|
40,717.30 | 36.36 | 12 | 32 |
|
protein poly-ADP-ribosylation
|
28,954.52 | 26.09 | 12 | 45 |
|
NAD+-protein-lysine ADP-ribosyltransferase activity
|
62,045.41 | 25.00 | 4 | 7 |
|
protein auto-ADP-ribosylation
|
23,690.06 | 21.43 | 12 | 55 |
|
hippocampal neuron apoptotic process
|
39,483.45 | 20.00 | 4 | 11 |
| Totals | 346 | 44763 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-11-25 | Added | TERM | NAD DNA ADP-ribosyltransferase activity |
| 2018-11-25 | Added | RELATION | is a GO:0016763 (pentosyltransferase activity) |
| 2018-11-25 | Added | DEFINITION | Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-11-25 | Added | TERM | NAD DNA ADP-ribosyltransferase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-11-25 | Added | DEFINITION | Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-11-25 | Added | RELATION | is a GO:0016763 (pentosyltransferase activity) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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