GO:0140467
JSON
integrated stress response signaling
Biological Process
Definition (GO:0140467 GONUTS page)
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. PMID:27629041
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ISR | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140467
Child Term | Relationship to GO:0140467 |
---|---|
PKR/eIFalpha signaling
|
is_a |
GCN2-mediated signaling
|
is_a |
HRI-mediated signaling
|
is_a |
PERK-mediated unfolded protein response
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Cross-references
Database | ID | Description |
---|---|---|
Wikipedia | Integrated_stress_response |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140467 based on ALL annotations
The top 100 of 456 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
integrated stress response signaling
|
375,604.60 | 100.00 | 519 | 519 |
HRI-mediated signaling
|
215,208.16 | 46.80 | 373 | 651 |
PERK-mediated unfolded protein response
|
113,903.76 | 20.71 | 205 | 676 |
L-asparagine metabolic process
|
375,604.60 | 18.50 | 96 | 96 |
CHOP-ATF4 complex
|
100,851.74 | 18.08 | 185 | 689 |
regulation of cristae formation
|
349,312.28 | 17.68 | 93 | 100 |
negative regulation of hemoglobin biosynthetic process
|
371,521.94 | 17.50 | 91 | 92 |
intrinsic apoptotic signaling pathway in response to nitrosative stress
|
371,133.12 | 15.96 | 83 | 84 |
leucine zipper domain binding
|
80,987.01 | 15.52 | 185 | 858 |
positive regulation of sodium-dependent phosphate transport
|
203,452.48 | 15.27 | 91 | 168 |
Totals | 9737 | 872089 |
No co-occurrence statistics for GO:0140467 based on MANUAL annotations
The top 100 of 296 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
integrated stress response signaling
|
19,280.58 | 100.00 | 67 | 67 |
HRI-mediated signaling
|
11,195.18 | 22.50 | 18 | 31 |
PERK-mediated unfolded protein response
|
7,230.22 | 16.30 | 15 | 40 |
regulation of cristae formation
|
16,067.15 | 7.35 | 5 | 6 |
negative regulation of hemoglobin biosynthetic process
|
19,280.58 | 5.97 | 4 | 4 |
ATF1-ATF4 transcription factor complex
|
3,109.77 | 5.38 | 5 | 31 |
CHOP-ATF4 complex
|
4,284.57 | 4.94 | 4 | 18 |
cAMP response element binding protein binding
|
1,645.90 | 4.93 | 7 | 82 |
response to iron ion starvation
|
2,295.31 | 4.81 | 5 | 42 |
CHOP-C/EBP complex
|
3,353.14 | 4.65 | 4 | 23 |
Totals | 421 | 14508 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-10 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2020-05-29 | Added | DEFINITION | The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. |
2020-05-29 | Added | XREF | Wikipedia:Integrated_stress_response |
2020-05-29 | Added | SYNONYM | ISR |
2020-05-29 | Added | RELATION | is a GO:0033554 (cellular response to stress) |
2020-05-29 | Added | TERM | integrated stress response signaling |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-29 | Added | TERM | integrated stress response signaling |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-29 | Added | DEFINITION | The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. |
2020-05-29 | Added | SYNONYM | ISR |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-10 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2020-05-29 | Added | RELATION | is a GO:0033554 (cellular response to stress) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-29 | Added | XREF | Wikipedia:Integrated_stress_response |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link