This term is obsolete.

GO:0140467 JSON

integrated stress response signaling

Biological Process

Definition (GO:0140467 GONUTS page)

The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. PMID:27629041

8,391 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ISR related

Ancestor Chart

Ancestor chart for GO:0140467
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140467

Child Term Relationship to
GO:0140467
PERK-mediated unfolded protein response
is_a
GCN2-mediated signaling
is_a
HRI-mediated signaling
is_a
PKR/eIFalpha signaling
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
Wikipedia Integrated_stress_response

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140467 based on ALL annotations
The top 100 of 457 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrated stress response signaling
383,278.28 100.00 517 517
HRI-mediated signaling
219,438.62 46.73 371 648
PERK-mediated unfolded protein response
110,044.88 19.98 205 714
L-asparagine metabolic process
383,278.25 18.57 96 96
CHOP-ATF4 complex
100,032.91 17.73 184 705
negative regulation of hemoglobin biosynthetic process
379,112.20 17.57 91 92
regulation of cristae formation
356,177.78 17.56 92 99
intrinsic apoptotic signaling pathway in response to nitrosative stress
378,660.44 15.83 82 83
leucine zipper domain binding
82,386.92 15.48 184 856
positive regulation of sodium-dependent phosphate transport
207,609.05 15.32 91 168
Totals 9604 848685
No co-occurrence statistics for GO:0140467 based on MANUAL annotations
The top 100 of 297 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrated stress response signaling
21,067.66 100.00 67 67
HRI-mediated signaling
12,232.83 22.50 18 31
PERK-mediated unfolded protein response
5,016.11 13.04 15 63
regulation of cristae formation
17,556.38 7.35 5 6
negative regulation of hemoglobin biosynthetic process
21,067.66 5.97 4 4
ATF1-ATF4 transcription factor complex
2,926.06 5.10 5 36
CHOP-ATF4 complex
4,213.53 4.82 4 20
response to iron ion starvation
2,340.85 4.67 5 45
cAMP response element binding protein binding
1,602.97 4.61 7 92
CHOP-C/EBP complex
3,370.83 4.55 4 25
Totals 415 14483

Change Log

Timestamp Action Category Detail
2024-04-10 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2020-05-29 Added SYNONYM ISR
2020-05-29 Added RELATION is a GO:0033554 (cellular response to stress)
2020-05-29 Added XREF Wikipedia:Integrated_stress_response
2020-05-29 Added DEFINITION The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
2020-05-29 Added TERM integrated stress response signaling
Timestamp Action Category Detail
2020-05-29 Added TERM integrated stress response signaling
Timestamp Action Category Detail
2020-05-29 Added SYNONYM ISR
2020-05-29 Added DEFINITION The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
Timestamp Action Category Detail
2024-04-10 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2020-05-29 Added RELATION is a GO:0033554 (cellular response to stress)
Timestamp Action Category Detail
2020-05-29 Added XREF Wikipedia:Integrated_stress_response
Timestamp Action Category Detail
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