This term is obsolete.

GO:0140467 JSON

integrated stress response signaling

Biological Process

Definition (GO:0140467 GONUTS page)

The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. PMID:27629041

8,240 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ISR related

Ancestor Chart

Ancestor chart for GO:0140467
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140467

Child Term Relationship to
GO:0140467
PKR/eIFalpha signaling
is_a
GCN2-mediated signaling
is_a
HRI-mediated signaling
is_a
PERK-mediated unfolded protein response
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
Wikipedia Integrated_stress_response

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140467 based on ALL annotations
The top 100 of 456 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrated stress response signaling
375,604.60 100.00 519 519
HRI-mediated signaling
215,208.16 46.80 373 651
PERK-mediated unfolded protein response
113,903.76 20.71 205 676
L-asparagine metabolic process
375,604.60 18.50 96 96
CHOP-ATF4 complex
100,851.74 18.08 185 689
regulation of cristae formation
349,312.28 17.68 93 100
negative regulation of hemoglobin biosynthetic process
371,521.94 17.50 91 92
intrinsic apoptotic signaling pathway in response to nitrosative stress
371,133.12 15.96 83 84
leucine zipper domain binding
80,987.01 15.52 185 858
positive regulation of sodium-dependent phosphate transport
203,452.48 15.27 91 168
Totals 9737 872089
No co-occurrence statistics for GO:0140467 based on MANUAL annotations
The top 100 of 296 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrated stress response signaling
19,280.58 100.00 67 67
HRI-mediated signaling
11,195.18 22.50 18 31
PERK-mediated unfolded protein response
7,230.22 16.30 15 40
regulation of cristae formation
16,067.15 7.35 5 6
negative regulation of hemoglobin biosynthetic process
19,280.58 5.97 4 4
ATF1-ATF4 transcription factor complex
3,109.77 5.38 5 31
CHOP-ATF4 complex
4,284.57 4.94 4 18
cAMP response element binding protein binding
1,645.90 4.93 7 82
response to iron ion starvation
2,295.31 4.81 5 42
CHOP-C/EBP complex
3,353.14 4.65 4 23
Totals 421 14508

Change Log

Timestamp Action Category Detail
2024-04-10 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2020-05-29 Added DEFINITION The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
2020-05-29 Added XREF Wikipedia:Integrated_stress_response
2020-05-29 Added SYNONYM ISR
2020-05-29 Added RELATION is a GO:0033554 (cellular response to stress)
2020-05-29 Added TERM integrated stress response signaling
Timestamp Action Category Detail
2020-05-29 Added TERM integrated stress response signaling
Timestamp Action Category Detail
2020-05-29 Added DEFINITION The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
2020-05-29 Added SYNONYM ISR
Timestamp Action Category Detail
2024-04-10 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2020-05-29 Added RELATION is a GO:0033554 (cellular response to stress)
Timestamp Action Category Detail
2020-05-29 Added XREF Wikipedia:Integrated_stress_response
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.