This term is obsolete.

GO:0140468 JSON

HRI-mediated signaling

Biological Process

Definition (GO:0140468 GONUTS page)

A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. PMID:27629041

679 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
EIF2AK1-mediated signaling exact

Ancestor Chart

Ancestor chart for GO:0140468
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Ancestor chart

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140468 based on ALL annotations
The top 100 of 247 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HRI-mediated signaling
305,794.53 100.00 648 648
integrated stress response signaling
219,438.64 46.73 371 517
PERK-mediated unfolded protein response
86,513.31 17.41 202 714
CHOP-ATF4 complex
79,810.21 15.74 184 705
regulation of translation in response to endoplasmic reticulum stress
241,291.00 14.96 101 128
L-asparagine metabolic process
305,794.53 14.81 96 96
regulation of cristae formation
284,172.72 14.05 92 99
negative regulation of hemoglobin biosynthetic process
302,470.72 14.02 91 92
leucine zipper domain binding
65,731.55 13.94 184 856
response to iron ion starvation
68,042.25 13.77 172 773
Totals 10296 755991
No co-occurrence statistics for GO:0140468 based on MANUAL annotations
The top 100 of 207 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HRI-mediated signaling
45,533.32 100.00 31 31
integrated stress response signaling
12,232.83 22.50 18 67
PERK-mediated unfolded protein response
9,395.77 16.05 13 63
regulation of cristae formation
37,944.43 15.63 5 6
negative regulation of hemoglobin biosynthetic process
45,533.32 12.90 4 4
negative regulation of translational initiation in response to stress
5,691.67 9.57 9 72
response to iron ion starvation
6,071.11 8.57 6 45
CHOP-ATF4 complex
9,106.66 8.51 4 20
ATF1-ATF4 transcription factor complex
6,324.07 8.06 5 36
regulation of translational initiation in response to stress
11,383.33 7.50 3 12
Totals 375 17295

Change Log

Timestamp Action Category Detail
2020-06-02 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
2020-06-02 Deleted DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added SYNONYM EIF2AK1-mediated signaling
2020-05-29 Added RELATION is a GO:0140467 (integrated stress response signaling)
2020-05-29 Added TERM HRI-mediated signaling
Timestamp Action Category Detail
2020-05-29 Added TERM HRI-mediated signaling
Timestamp Action Category Detail
2020-06-02 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
2020-06-02 Deleted DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added SYNONYM EIF2AK1-mediated signaling
Timestamp Action Category Detail
2020-05-29 Added RELATION is a GO:0140467 (integrated stress response signaling)
Timestamp Action Category Detail
Timestamp Action Category Detail
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