GO:0140468
JSON
HRI-mediated signaling
Biological Process
Definition (GO:0140468 GONUTS page)
A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. PMID:27629041
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
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EIF2AK1-mediated signaling | exact |
Ancestor Chart
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140468 based on ALL annotations
The top 100 of 248 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
HRI-mediated signaling
|
299,445.12 | 100.00 | 651 | 651 |
integrated stress response signaling
|
215,208.16 | 46.80 | 373 | 519 |
PERK-mediated unfolded protein response
|
89,479.16 | 17.96 | 202 | 676 |
CHOP-ATF4 complex
|
80,402.55 | 16.02 | 185 | 689 |
regulation of translation in response to endoplasmic reticulum stress
|
238,141.40 | 14.92 | 101 | 127 |
L-asparagine metabolic process
|
299,445.16 | 14.75 | 96 | 96 |
regulation of cristae formation
|
278,484.00 | 14.13 | 93 | 100 |
leucine zipper domain binding
|
64,565.68 | 13.97 | 185 | 858 |
negative regulation of hemoglobin biosynthetic process
|
296,190.30 | 13.96 | 91 | 92 |
response to iron ion starvation
|
67,629.26 | 13.91 | 173 | 766 |
Totals | 10341 | 737893 |
No co-occurrence statistics for GO:0140468 based on MANUAL annotations
The top 100 of 207 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
HRI-mediated signaling
|
41,670.93 | 100.00 | 31 | 31 |
integrated stress response signaling
|
11,195.18 | 22.50 | 18 | 67 |
PERK-mediated unfolded protein response
|
13,543.05 | 22.41 | 13 | 40 |
regulation of cristae formation
|
34,725.78 | 15.63 | 5 | 6 |
negative regulation of hemoglobin biosynthetic process
|
41,670.93 | 12.90 | 4 | 4 |
negative regulation of translational initiation in response to stress
|
5,357.69 | 9.78 | 9 | 70 |
response to iron ion starvation
|
5,952.99 | 8.96 | 6 | 42 |
CHOP-ATF4 complex
|
9,260.21 | 8.89 | 4 | 18 |
ATF1-ATF4 transcription factor complex
|
6,721.12 | 8.77 | 5 | 31 |
regulation of translational initiation in response to stress
|
12,501.28 | 7.89 | 3 | 10 |
Totals | 374 | 16475 |
Change Log
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Timestamp | Action | Category | Detail |
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2020-06-02 | Added | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. |
2020-06-02 | Deleted | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals. |
2020-05-29 | Added | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals. |
2020-05-29 | Added | RELATION | is a GO:0140467 (integrated stress response signaling) |
2020-05-29 | Added | TERM | HRI-mediated signaling |
2020-05-29 | Added | SYNONYM | EIF2AK1-mediated signaling |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-29 | Added | TERM | HRI-mediated signaling |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-02 | Added | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. |
2020-06-02 | Deleted | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals. |
2020-05-29 | Added | DEFINITION | A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals. |
2020-05-29 | Added | SYNONYM | EIF2AK1-mediated signaling |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-29 | Added | RELATION | is a GO:0140467 (integrated stress response signaling) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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