This term is obsolete.

GO:0140468 JSON

HRI-mediated signaling

Biological Process

Definition (GO:0140468 GONUTS page)

A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. PMID:27629041

682 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
EIF2AK1-mediated signaling exact

Ancestor Chart

Ancestor chart for GO:0140468
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Ancestor chart

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140468 based on ALL annotations
The top 100 of 248 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HRI-mediated signaling
299,445.12 100.00 651 651
integrated stress response signaling
215,208.16 46.80 373 519
PERK-mediated unfolded protein response
89,479.16 17.96 202 676
CHOP-ATF4 complex
80,402.55 16.02 185 689
regulation of translation in response to endoplasmic reticulum stress
238,141.40 14.92 101 127
L-asparagine metabolic process
299,445.16 14.75 96 96
regulation of cristae formation
278,484.00 14.13 93 100
leucine zipper domain binding
64,565.68 13.97 185 858
negative regulation of hemoglobin biosynthetic process
296,190.30 13.96 91 92
response to iron ion starvation
67,629.26 13.91 173 766
Totals 10341 737893
No co-occurrence statistics for GO:0140468 based on MANUAL annotations
The top 100 of 207 co-occurring terms
Co-occurring Term PR S% #Together #Compared
HRI-mediated signaling
41,670.93 100.00 31 31
integrated stress response signaling
11,195.18 22.50 18 67
PERK-mediated unfolded protein response
13,543.05 22.41 13 40
regulation of cristae formation
34,725.78 15.63 5 6
negative regulation of hemoglobin biosynthetic process
41,670.93 12.90 4 4
negative regulation of translational initiation in response to stress
5,357.69 9.78 9 70
response to iron ion starvation
5,952.99 8.96 6 42
CHOP-ATF4 complex
9,260.21 8.89 4 18
ATF1-ATF4 transcription factor complex
6,721.12 8.77 5 31
regulation of translational initiation in response to stress
12,501.28 7.89 3 10
Totals 374 16475

Change Log

Timestamp Action Category Detail
2020-06-02 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
2020-06-02 Deleted DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added RELATION is a GO:0140467 (integrated stress response signaling)
2020-05-29 Added TERM HRI-mediated signaling
2020-05-29 Added SYNONYM EIF2AK1-mediated signaling
Timestamp Action Category Detail
2020-05-29 Added TERM HRI-mediated signaling
Timestamp Action Category Detail
2020-06-02 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.
2020-06-02 Deleted DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added DEFINITION A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals.
2020-05-29 Added SYNONYM EIF2AK1-mediated signaling
Timestamp Action Category Detail
2020-05-29 Added RELATION is a GO:0140467 (integrated stress response signaling)
Timestamp Action Category Detail
Timestamp Action Category Detail
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