GO:0140566
JSON
histone reader activity
Molecular Function
Definition (GO:0140566 GONUTS page)
A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. PMID:11498575 PMID:25688442 PMID:31082667 PMID:34726351
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
epigenetic reader | broad |
histone reader | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140566
Child Term | Relationship to GO:0140566 |
---|---|
histone H2A reader activity
|
is_a |
histone H4 reader activity
|
is_a |
histone H3 reader activity
|
is_a |
ubiquitin-modified histone reader activity
|
is_a |
histone H2B reader activity
|
is_a |
unmodified histone reader activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR049914 | PHD finger-containing protein 1-3/5-6 |
InterPro | IPR049937 | Chp1, chromodomain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140566 based on ALL annotations
The top 100 of 606 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone reader activity
|
34,782.32 | 100.00 | 5,697 | 5,697 |
negative regulation of transcription elongation by RNA polymerase II
|
11,136.43 | 27.40 | 3,731 | 11,653 |
positive regulation of cell adhesion involved in single-species biofilm formation
|
28,725.69 | 2.90 | 166 | 201 |
positive regulation of mating type switching
|
27,758.96 | 2.89 | 166 | 208 |
positive regulation of invasive growth in response to glucose limitation
|
18,685.65 | 2.84 | 166 | 309 |
histone crotonyltransferase activity
|
14,964.49 | 2.51 | 148 | 344 |
ADA complex
|
11,465.00 | 2.47 | 148 | 449 |
lysine-acetylated histone binding
|
1,013.49 | 2.45 | 764 | 26,220 |
negative regulation of induction of conjugation with cellular fusion
|
6,759.32 | 2.29 | 144 | 741 |
ATAC complex
|
1,497.99 | 1.95 | 196 | 4,551 |
Totals | 20988 | 538997 |
No co-occurrence statistics for GO:0140566 based on MANUAL annotations
The top 100 of 491 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone reader activity
|
11,665.56 | 100.00 | 121 | 121 |
UFM1-modified protein reader activity
|
5,302.53 | 7.52 | 10 | 22 |
poly-ADP-D-ribose modification-dependent protein binding
|
3,888.52 | 6.47 | 9 | 27 |
positive regulation of T-helper 17 cell lineage commitment
|
2,430.33 | 6.29 | 10 | 48 |
GTP-dependent protein kinase activity
|
5,832.78 | 6.20 | 8 | 16 |
lysine-acetylated histone binding
|
803.77 | 5.96 | 37 | 537 |
RNA polymerase II C-terminal domain binding
|
2,499.76 | 5.84 | 9 | 42 |
ubiquitin-like protein reader activity
|
10,207.37 | 5.74 | 7 | 8 |
P-TEFb complex binding
|
1,567.02 | 5.03 | 9 | 67 |
phosphorylated histone binding
|
9,999.05 | 4.92 | 6 | 7 |
Totals | 711 | 14181 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-21 | Added | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2025-01-21 | Deleted | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2024-12-15 | Deleted | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2024-12-15 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2024-12-02 | Added | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-02 | Deleted | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-01 | Deleted | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-01 | Added | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-11-30 | Deleted | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-11-30 | Added | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Updated | TERM | histone reader activity |
2022-01-12 | Updated | TERM | histone reader |
2020-12-17 | Added | TERM | epigenetic reader |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-02 | Added | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-02 | Deleted | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-01 | Deleted | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-12-01 | Added | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-11-30 | Deleted | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2024-11-30 | Added | DEFINITION | A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2022-01-22 | Added | SYNONYM | histone reader |
2022-01-12 | Deleted | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
2022-01-12 | Added | SYNONYM | epigenetic reader |
2022-01-12 | Added | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2020-12-17 | Added | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-21 | Added | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2025-01-21 | Deleted | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2024-12-15 | Deleted | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2024-12-15 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2022-07-18 | Added | RELATION | occurs in GO:0000786 (nucleosome) |
2021-11-08 | Deleted | RELATION | is a GO:0140110 (transcription regulator activity) |
2021-11-08 | Added | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2020-12-17 | Added | RELATION | is a GO:0140110 (transcription regulator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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