GO:0140566
JSON
histone reader activity
Molecular Function
Definition (GO:0140566 GONUTS page)
A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. PMID:11498575 PMID:25688442 PMID:31082667 PMID:32260176 PMID:34726351
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
epigenetic reader | broad |
histone reader | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140566
Child Term | Relationship to GO:0140566 |
---|---|
ubiquitin-modified histone reader activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR049914 | PHD finger-containing protein 1-3/5-6 |
InterPro | IPR049937 | Chp1, chromodomain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140566 based on ALL annotations
The top 100 of 593 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone reader activity
|
36,780.90 | 100.00 | 5,300 | 5,300 |
negative regulation of transcription elongation by RNA polymerase II
|
11,398.81 | 26.57 | 3,449 | 11,129 |
regulation of tubulin deacetylation
|
6,524.03 | 3.16 | 196 | 1,105 |
positive regulation of mating type switching
|
29,353.99 | 3.11 | 166 | 208 |
positive regulation of cell adhesion involved in single-species biofilm formation
|
27,627.28 | 3.10 | 166 | 221 |
positive regulation of invasive growth in response to glucose limitation
|
19,759.32 | 3.05 | 166 | 309 |
ADA complex
|
12,178.57 | 2.66 | 149 | 450 |
lysine-acetylated histone binding
|
1,110.73 | 2.56 | 770 | 25,498 |
negative regulation of induction of conjugation with cellular fusion
|
7,158.70 | 2.46 | 145 | 745 |
histone crotonyltransferase activity
|
4,136.12 | 2.30 | 149 | 1,325 |
Totals | 24965 | 958657 |
No co-occurrence statistics for GO:0140566 based on MANUAL annotations
The top 100 of 480 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone reader activity
|
10,676.02 | 100.00 | 121 | 121 |
UFM1-modified protein reader activity
|
4,852.74 | 7.52 | 10 | 22 |
lysine-acetylated histone binding
|
851.59 | 6.90 | 41 | 514 |
poly-ADP-D-ribose modification-dependent protein binding
|
3,558.67 | 6.47 | 9 | 27 |
regulation of tubulin deacetylation
|
1,864.07 | 6.36 | 11 | 63 |
GTP-dependent protein kinase activity
|
5,338.01 | 6.20 | 8 | 16 |
RNA polymerase II C-terminal domain binding
|
2,463.70 | 5.96 | 9 | 39 |
phosphorylated histone binding
|
10,676.02 | 5.79 | 7 | 7 |
ubiquitin-like protein reader activity
|
9,341.52 | 5.74 | 7 | 8 |
positive regulation of T-helper 17 cell lineage commitment
|
2,088.79 | 5.70 | 9 | 46 |
Totals | 729 | 14246 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-18 | Added | RELATION | occurs in GO:0000786 (nucleosome) |
2022-01-22 | Updated | TERM | histone reader activity |
2022-01-22 | Added | SYNONYM | histone reader |
2022-01-12 | Deleted | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
2022-01-12 | Updated | TERM | histone reader |
2022-01-12 | Added | SYNONYM | epigenetic reader |
2022-01-12 | Added | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2021-11-08 | Added | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2021-11-08 | Deleted | RELATION | is a GO:0140110 (transcription regulator activity) |
2020-12-17 | Added | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Updated | TERM | histone reader activity |
2022-01-12 | Updated | TERM | histone reader |
2020-12-17 | Added | TERM | epigenetic reader |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Added | SYNONYM | histone reader |
2022-01-12 | Deleted | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
2022-01-12 | Added | SYNONYM | epigenetic reader |
2022-01-12 | Added | DEFINITION | A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. |
2020-12-17 | Added | DEFINITION | A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-18 | Added | RELATION | occurs in GO:0000786 (nucleosome) |
2021-11-08 | Added | RELATION | is a GO:0140463 (chromatin-protein adaptor activity) |
2021-11-08 | Deleted | RELATION | is a GO:0140110 (transcription regulator activity) |
2020-12-17 | Added | RELATION | is a GO:0140110 (transcription regulator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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