This term is obsolete.

GO:0140566 JSON

histone reader activity

Molecular Function

Definition (GO:0140566 GONUTS page)

A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. PMID:11498575 PMID:25688442 PMID:31082667 PMID:32260176 PMID:34726351

5,988 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
epigenetic reader broad
histone reader exact

Ancestor Chart

Ancestor chart for GO:0140566
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140566

Child Term Relationship to
GO:0140566
ubiquitin-modified histone reader activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717

Cross-references

Database ID Description
InterPro IPR049914 PHD finger-containing protein 1-3/5-6
InterPro IPR049937 Chp1, chromodomain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140566 based on ALL annotations
The top 100 of 593 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone reader activity
36,780.90 100.00 5,300 5,300
negative regulation of transcription elongation by RNA polymerase II
11,398.81 26.57 3,449 11,129
regulation of tubulin deacetylation
6,524.03 3.16 196 1,105
positive regulation of mating type switching
29,353.99 3.11 166 208
positive regulation of cell adhesion involved in single-species biofilm formation
27,627.28 3.10 166 221
positive regulation of invasive growth in response to glucose limitation
19,759.32 3.05 166 309
ADA complex
12,178.57 2.66 149 450
lysine-acetylated histone binding
1,110.73 2.56 770 25,498
negative regulation of induction of conjugation with cellular fusion
7,158.70 2.46 145 745
histone crotonyltransferase activity
4,136.12 2.30 149 1,325
Totals 24965 958657
No co-occurrence statistics for GO:0140566 based on MANUAL annotations
The top 100 of 480 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone reader activity
10,676.02 100.00 121 121
UFM1-modified protein reader activity
4,852.74 7.52 10 22
lysine-acetylated histone binding
851.59 6.90 41 514
poly-ADP-D-ribose modification-dependent protein binding
3,558.67 6.47 9 27
regulation of tubulin deacetylation
1,864.07 6.36 11 63
GTP-dependent protein kinase activity
5,338.01 6.20 8 16
RNA polymerase II C-terminal domain binding
2,463.70 5.96 9 39
phosphorylated histone binding
10,676.02 5.79 7 7
ubiquitin-like protein reader activity
9,341.52 5.74 7 8
positive regulation of T-helper 17 cell lineage commitment
2,088.79 5.70 9 46
Totals 729 14246

Change Log

Timestamp Action Category Detail
2022-07-18 Added RELATION occurs in GO:0000786 (nucleosome)
2022-01-22 Updated TERM histone reader activity
2022-01-22 Added SYNONYM histone reader
2022-01-12 Deleted DEFINITION A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery.
2022-01-12 Updated TERM histone reader
2022-01-12 Added SYNONYM epigenetic reader
2022-01-12 Added DEFINITION A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.
2021-11-08 Added RELATION is a GO:0140463 (chromatin-protein adaptor activity)
2021-11-08 Deleted RELATION is a GO:0140110 (transcription regulator activity)
2020-12-17 Added DEFINITION A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery.
Timestamp Action Category Detail
2022-01-22 Updated TERM histone reader activity
2022-01-12 Updated TERM histone reader
2020-12-17 Added TERM epigenetic reader
Timestamp Action Category Detail
2022-01-22 Added SYNONYM histone reader
2022-01-12 Deleted DEFINITION A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery.
2022-01-12 Added SYNONYM epigenetic reader
2022-01-12 Added DEFINITION A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.
2020-12-17 Added DEFINITION A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery.
Timestamp Action Category Detail
2022-07-18 Added RELATION occurs in GO:0000786 (nucleosome)
2021-11-08 Added RELATION is a GO:0140463 (chromatin-protein adaptor activity)
2021-11-08 Deleted RELATION is a GO:0140110 (transcription regulator activity)
2020-12-17 Added RELATION is a GO:0140110 (transcription regulator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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