GO:0140664
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ATP-dependent DNA damage sensor activity
Molecular Function
Definition (GO:0140664 GONUTS page)
A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. PMID:33302090 PMID:33510387
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP-dependent DNA damage sensing activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
InterPro | IPR038973 | DNA mismatch repair protein MutL/Mlh/Pms-like |
InterPro | IPR045076 | DNA mismatch repair MutS |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0042769 | obsolete DNA damage response, detection of DNA damage | consider GO:0140664 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140664 based on ALL annotations
The top 100 of 1,130 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ATP-dependent DNA damage sensor activity
|
690.23 | 100.00 | 282,426 | 282,426 |
mismatched DNA binding
|
636.20 | 49.64 | 146,368 | 158,799 |
mismatch repair
|
341.46 | 34.66 | 151,537 | 306,322 |
damaged DNA binding
|
203.34 | 20.08 | 109,253 | 370,855 |
mismatch repair complex
|
690.22 | 19.59 | 55,330 | 55,331 |
ATP-dependent activity, acting on DNA
|
345.15 | 15.98 | 53,723 | 107,435 |
single-stranded DNA binding
|
119.90 | 11.95 | 78,176 | 450,028 |
double-stranded DNA binding
|
125.59 | 8.58 | 39,458 | 216,854 |
recombinational repair
|
117.44 | 8.05 | 37,465 | 220,192 |
DNA repair
|
54.96 | 7.76 | 213,617 | 2,682,566 |
Totals | 2590154 | 148932417 |
No co-occurrence statistics for GO:0140664 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ATP-dependent DNA damage sensor activity
|
86,119.94 | 100.00 | 15 | 15 |
Rad51B-Rad51C-Rad51D-XRCC2 complex
|
6,590.81 | 7.65 | 15 | 196 |
telomere maintenance via recombination
|
4,321.43 | 5.00 | 14 | 279 |
DNA strand invasion
|
3,856.12 | 4.48 | 15 | 335 |
chromosome organization
|
2,930.78 | 3.39 | 13 | 382 |
four-way junction DNA binding
|
1,951.36 | 2.27 | 15 | 662 |
gamma-tubulin binding
|
1,658.43 | 1.92 | 14 | 727 |
chromosome, telomeric region
|
1,428.53 | 1.66 | 14 | 844 |
replication fork
|
1,326.28 | 1.54 | 15 | 974 |
interstrand cross-link repair
|
1,201.24 | 1.39 | 13 | 932 |
Totals | 294 | 367616 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-14 | Added | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. |
2023-07-14 | Deleted | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
2022-04-05 | Added | SYNONYM | ATP-dependent DNA damage sensing activity |
2021-07-06 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2021-07-06 | Deleted | RELATION | is a GO:0140657 (ATP-dependent activity) |
2021-06-22 | Added | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
2021-06-22 | Added | RELATION | is a GO:0140657 (ATP-dependent activity) |
2021-06-22 | Added | TERM | ATP-dependent DNA damage sensor activity |
2021-06-22 | Added | RELATION | is a GO:0140612 (DNA damage sensor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-22 | Added | TERM | ATP-dependent DNA damage sensor activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-14 | Added | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. |
2023-07-14 | Deleted | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
2022-04-05 | Added | SYNONYM | ATP-dependent DNA damage sensing activity |
2021-06-22 | Added | DEFINITION | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-06 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2021-07-06 | Deleted | RELATION | is a GO:0140657 (ATP-dependent activity) |
2021-06-22 | Added | RELATION | is a GO:0140657 (ATP-dependent activity) |
2021-06-22 | Added | RELATION | is a GO:0140612 (DNA damage sensor activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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