This term is obsolete.

GO:0140664 JSON

ATP-dependent DNA damage sensor activity

Molecular Function

Definition (GO:0140664 GONUTS page)

A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. PMID:33302090 PMID:33510387

282,437 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP-dependent DNA damage sensing activity exact

Ancestor Chart

Ancestor chart for GO:0140664
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
InterPro IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
InterPro IPR038973 DNA mismatch repair protein MutL/Mlh/Pms-like
InterPro IPR045076 DNA mismatch repair MutS

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0042769 obsolete DNA damage response, detection of DNA damage consider GO:0140664

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140664 based on ALL annotations
The top 100 of 1,130 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent DNA damage sensor activity
690.23 100.00 282,426 282,426
mismatched DNA binding
636.20 49.64 146,368 158,799
mismatch repair
341.46 34.66 151,537 306,322
damaged DNA binding
203.34 20.08 109,253 370,855
mismatch repair complex
690.22 19.59 55,330 55,331
ATP-dependent activity, acting on DNA
345.15 15.98 53,723 107,435
single-stranded DNA binding
119.90 11.95 78,176 450,028
double-stranded DNA binding
125.59 8.58 39,458 216,854
recombinational repair
117.44 8.05 37,465 220,192
DNA repair
54.96 7.76 213,617 2,682,566
Totals 2590154 148932417
No co-occurrence statistics for GO:0140664 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent DNA damage sensor activity
86,119.94 100.00 15 15
Rad51B-Rad51C-Rad51D-XRCC2 complex
6,590.81 7.65 15 196
telomere maintenance via recombination
4,321.43 5.00 14 279
DNA strand invasion
3,856.12 4.48 15 335
chromosome organization
2,930.78 3.39 13 382
four-way junction DNA binding
1,951.36 2.27 15 662
gamma-tubulin binding
1,658.43 1.92 14 727
chromosome, telomeric region
1,428.53 1.66 14 844
replication fork
1,326.28 1.54 15 974
interstrand cross-link repair
1,201.24 1.39 13 932
Totals 294 367616

Change Log

Timestamp Action Category Detail
2023-07-14 Added DEFINITION A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.
2023-07-14 Deleted DEFINITION A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
2022-04-05 Added SYNONYM ATP-dependent DNA damage sensing activity
2021-07-06 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-07-06 Deleted RELATION is a GO:0140657 (ATP-dependent activity)
2021-06-22 Added DEFINITION A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
2021-06-22 Added RELATION is a GO:0140657 (ATP-dependent activity)
2021-06-22 Added TERM ATP-dependent DNA damage sensor activity
2021-06-22 Added RELATION is a GO:0140612 (DNA damage sensor activity)
Timestamp Action Category Detail
2021-06-22 Added TERM ATP-dependent DNA damage sensor activity
Timestamp Action Category Detail
2023-07-14 Added DEFINITION A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis.
2023-07-14 Deleted DEFINITION A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
2022-04-05 Added SYNONYM ATP-dependent DNA damage sensing activity
2021-06-22 Added DEFINITION A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
Timestamp Action Category Detail
2021-07-06 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-07-06 Deleted RELATION is a GO:0140657 (ATP-dependent activity)
2021-06-22 Added RELATION is a GO:0140657 (ATP-dependent activity)
2021-06-22 Added RELATION is a GO:0140612 (DNA damage sensor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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