This term is obsolete.

GO:0140684 JSON

histone H3K9me2/H3K9me3 demethylase activity

Molecular Function

Definition (GO:0140684 GONUTS page)

Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. PMID:20208542 PMID:20531378

2,901 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histone H3K9me3 demethylase activity related
histone H3K9me2 demethylase activity broad
histone H3-tri/dimethyl-lysine-9 demethylase activity exact

Ancestor Chart

Ancestor chart for GO:0140684
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A0G2K2I9 10116 A0A0G2K2I9_RAT GO:0016706 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2KAI2 10116 A0A0G2KAI2_RAT GO:0032452 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8FY27 8355 A0A1L8FY27_XENLA GO:0032452 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.14.11.66
RHEA 60200

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)
has_participant CHEBI CHEBI:16526 carbon dioxide
has_participant CHEBI CHEBI:30031 succinate(2-)
has_participant CHEBI CHEBI:16842 formaldehyde
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:61961 N(6),N(6),N(6)-trimethyl-L-lysine residue
has_participant CHEBI CHEBI:61929 N(6)-methyl-L-lysinium residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140684 based on ALL annotations
The top 100 of 202 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H3K9me2/H3K9me3 demethylase activity
67,687.08 100.00 2,880 2,880
histone H3K36 demethylase activity
11,351.04 16.13 2,329 13,888
histone H3K9 demethylase activity
9,819.92 14.48 2,846 19,617
cardiac muscle hypertrophy in response to stress
5,821.21 2.42 94 1,093
histone demethylase activity
1,865.73 2.05 215 7,800
pericentric heterochromatin
1,697.74 1.89 206 8,213
androgen receptor signaling pathway
2,670.69 1.77 90 2,281
nuclear androgen receptor binding
1,931.59 1.55 95 3,329
temperature compensation of the circadian clock
21,602.26 1.02 30 94
regulation of seedling development
11,874.93 0.99 30 171
Totals 22779 4400966
No co-occurrence statistics for GO:0140684 based on MANUAL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H3K9me2/H3K9me3 demethylase activity
43,059.97 100.00 30 30
regulation of primitive erythrocyte differentiation
13,456.24 12.20 5 16
telomeric repeat-containing RNA binding
21,529.98 11.76 4 8
MRF binding
10,252.37 10.87 5 21
nuclear androgen receptor binding
3,189.63 6.67 12 162
histone H3K36me2/H3K36me3 demethylase activity
43,059.97 6.67 2 2
histone H3K36 demethylase activity
2,935.91 6.62 21 308
histone demethylase activity
2,803.38 6.43 25 384
response to fungicide
4,532.63 6.25 4 38
histone H3K9 demethylase activity
2,312.48 5.36 29 540
Totals 572 68949

Change Log

Timestamp Action Category Detail
2022-07-24 Added SYNONYM histone H3-tri/dimethyl-lysine-9 demethylase activity
2022-07-24 Updated TERM histone H3K9me2/H3K9me3 demethylase activity
2021-07-12 Added RELATION is a GO:0032454 (histone H3K9 demethylase activity)
2021-07-12 Added TERM histone H3-tri/dimethyl-lysine-9 demethylase activity
2021-07-12 Added DEFINITION Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
2021-07-12 Added XREF EC:1.14.11.66
2021-07-12 Added XREF RHEA:60200
2021-07-12 Added SYNONYM histone H3K9me3 demethylase activity
2021-07-12 Added SYNONYM histone H3K9me2 demethylase activity
2021-07-12 Added RELATION is a GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Timestamp Action Category Detail
2022-07-24 Updated TERM histone H3K9me2/H3K9me3 demethylase activity
2021-07-12 Added TERM histone H3-tri/dimethyl-lysine-9 demethylase activity
Timestamp Action Category Detail
2022-07-24 Added SYNONYM histone H3-tri/dimethyl-lysine-9 demethylase activity
2021-07-12 Added DEFINITION Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
2021-07-12 Added SYNONYM histone H3K9me3 demethylase activity
2021-07-12 Added SYNONYM histone H3K9me2 demethylase activity
Timestamp Action Category Detail
2021-07-12 Added RELATION is a GO:0032454 (histone H3K9 demethylase activity)
2021-07-12 Added RELATION is a GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Timestamp Action Category Detail
2021-07-12 Added XREF EC:1.14.11.66
2021-07-12 Added XREF RHEA:60200
Timestamp Action Category Detail
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