GO:0140684
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histone H3K9me2/H3K9me3 demethylase activity
Molecular Function
Definition (GO:0140684 GONUTS page)
Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. PMID:20208542 PMID:20531378
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
histone H3K9me3 demethylase activity | related |
histone H3K9me2 demethylase activity | broad |
histone H3-tri/dimethyl-lysine-9 demethylase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A0G2K2I9 | 10116 | A0A0G2K2I9_RAT | GO:0016706 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2KAI2 | 10116 | A0A0G2KAI2_RAT | GO:0032452 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8FY27 | 8355 | A0A1L8FY27_XENLA | GO:0032452 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.14.11.66 | |
RHEA | 60200 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
has_participant | CHEBI | CHEBI:30031 | succinate(2-) |
has_participant | CHEBI | CHEBI:16842 | formaldehyde |
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:61961 | N(6),N(6),N(6)-trimethyl-L-lysine residue |
has_participant | CHEBI | CHEBI:61929 | N(6)-methyl-L-lysinium residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140684 based on ALL annotations
The top 100 of 202 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H3K9me2/H3K9me3 demethylase activity
|
67,687.08 | 100.00 | 2,880 | 2,880 |
histone H3K36 demethylase activity
|
11,351.04 | 16.13 | 2,329 | 13,888 |
histone H3K9 demethylase activity
|
9,819.92 | 14.48 | 2,846 | 19,617 |
cardiac muscle hypertrophy in response to stress
|
5,821.21 | 2.42 | 94 | 1,093 |
histone demethylase activity
|
1,865.73 | 2.05 | 215 | 7,800 |
pericentric heterochromatin
|
1,697.74 | 1.89 | 206 | 8,213 |
androgen receptor signaling pathway
|
2,670.69 | 1.77 | 90 | 2,281 |
nuclear androgen receptor binding
|
1,931.59 | 1.55 | 95 | 3,329 |
temperature compensation of the circadian clock
|
21,602.26 | 1.02 | 30 | 94 |
regulation of seedling development
|
11,874.93 | 0.99 | 30 | 171 |
Totals | 22779 | 4400966 |
No co-occurrence statistics for GO:0140684 based on MANUAL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H3K9me2/H3K9me3 demethylase activity
|
43,059.97 | 100.00 | 30 | 30 |
regulation of primitive erythrocyte differentiation
|
13,456.24 | 12.20 | 5 | 16 |
telomeric repeat-containing RNA binding
|
21,529.98 | 11.76 | 4 | 8 |
MRF binding
|
10,252.37 | 10.87 | 5 | 21 |
nuclear androgen receptor binding
|
3,189.63 | 6.67 | 12 | 162 |
histone H3K36me2/H3K36me3 demethylase activity
|
43,059.97 | 6.67 | 2 | 2 |
histone H3K36 demethylase activity
|
2,935.91 | 6.62 | 21 | 308 |
histone demethylase activity
|
2,803.38 | 6.43 | 25 | 384 |
response to fungicide
|
4,532.63 | 6.25 | 4 | 38 |
histone H3K9 demethylase activity
|
2,312.48 | 5.36 | 29 | 540 |
Totals | 572 | 68949 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-24 | Added | SYNONYM | histone H3-tri/dimethyl-lysine-9 demethylase activity |
2022-07-24 | Updated | TERM | histone H3K9me2/H3K9me3 demethylase activity |
2021-07-12 | Added | RELATION | is a GO:0032454 (histone H3K9 demethylase activity) |
2021-07-12 | Added | TERM | histone H3-tri/dimethyl-lysine-9 demethylase activity |
2021-07-12 | Added | DEFINITION | Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. |
2021-07-12 | Added | XREF | EC:1.14.11.66 |
2021-07-12 | Added | XREF | RHEA:60200 |
2021-07-12 | Added | SYNONYM | histone H3K9me3 demethylase activity |
2021-07-12 | Added | SYNONYM | histone H3K9me2 demethylase activity |
2021-07-12 | Added | RELATION | is a GO:0016706 (2-oxoglutarate-dependent dioxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-24 | Updated | TERM | histone H3K9me2/H3K9me3 demethylase activity |
2021-07-12 | Added | TERM | histone H3-tri/dimethyl-lysine-9 demethylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-24 | Added | SYNONYM | histone H3-tri/dimethyl-lysine-9 demethylase activity |
2021-07-12 | Added | DEFINITION | Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. |
2021-07-12 | Added | SYNONYM | histone H3K9me3 demethylase activity |
2021-07-12 | Added | SYNONYM | histone H3K9me2 demethylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-12 | Added | RELATION | is a GO:0032454 (histone H3K9 demethylase activity) |
2021-07-12 | Added | RELATION | is a GO:0016706 (2-oxoglutarate-dependent dioxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-12 | Added | XREF | EC:1.14.11.66 |
2021-07-12 | Added | XREF | RHEA:60200 |
Timestamp | Action | Category | Detail |
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