GO:0140774
JSON
NAD-dependent protein depalmitoylase activity
Molecular Function
Definition (GO:0140774 GONUTS page)
Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. PMID:23552949
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
RHEA | 70563 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
has_participant | CHEBI | CHEBI:138936 | N(6)-hexadecanoyl-L-lysine residue |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:189673 | 2''-O-hexadecanoyl-ADP-D-ribose(2-) |
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140774 based on ALL annotations
The top 100 of 198 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD-dependent protein demyristoylase activity
|
385,254.50 | 100.00 | 506 | 506 |
NAD-dependent protein depalmitoylase activity
|
385,254.50 | 100.00 | 506 | 506 |
cellular response to caloric restriction
|
360,399.40 | 16.99 | 87 | 93 |
positive regulation of blood vessel branching
|
133,809.77 | 13.44 | 91 | 262 |
DNA damage sensor activity
|
115,076.02 | 12.74 | 92 | 308 |
positive regulation of oocyte maturation
|
117,488.96 | 12.25 | 86 | 282 |
NLRP3 inflammasome complex assembly
|
87,463.19 | 10.61 | 84 | 370 |
negative regulation of protein localization to chromatin
|
76,546.20 | 10.42 | 91 | 458 |
positive regulation of attachment of spindle microtubules to kinetochore
|
72,025.84 | 9.77 | 86 | 460 |
negative regulation of striated muscle tissue development
|
67,204.64 | 9.42 | 86 | 493 |
Totals | 10584 | 935170 |
No co-occurrence statistics for GO:0140774 based on MANUAL annotations
The top 100 of 175 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD-dependent protein demyristoylase activity
|
99,369.16 | 100.00 | 13 | 13 |
NAD-dependent protein depalmitoylase activity
|
99,369.16 | 100.00 | 13 | 13 |
histone H3K56 deacetylase activity, NAD-dependent
|
86,948.02 | 50.00 | 7 | 8 |
ketone biosynthetic process
|
86,948.02 | 50.00 | 7 | 8 |
negative regulation of oligodendrocyte progenitor proliferation
|
99,369.16 | 46.15 | 6 | 6 |
cellular response to caloric restriction
|
74,526.87 | 40.00 | 6 | 8 |
NAD-dependent protein lysine deacetylase activity
|
30,041.84 | 30.23 | 13 | 43 |
tubulin deacetylation
|
55,205.09 | 29.41 | 5 | 9 |
NAD+-protein-arginine ADP-ribosyltransferase activity
|
36,609.69 | 28.00 | 7 | 19 |
DNA damage sensor activity
|
33,123.05 | 25.93 | 7 | 21 |
Totals | 530 | 12268 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-08-12 | Added | XREF | RHEA:70563 |
2022-03-06 | Added | RELATION | part of GO:0043687 (post-translational protein modification) |
2022-03-06 | Added | RELATION | is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups) |
2022-03-06 | Added | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-03-06 | Added | TERM | NAD-dependent protein depalmitoylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-06 | Added | TERM | NAD-dependent protein depalmitoylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
2022-03-06 | Added | DEFINITION | Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-06 | Added | RELATION | part of GO:0043687 (post-translational protein modification) |
2022-03-06 | Added | RELATION | is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-08-12 | Added | XREF | RHEA:70563 |
Timestamp | Action | Category | Detail |
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