This term is obsolete.

GO:0140774 JSON

NAD-dependent protein depalmitoylase activity

Molecular Function

Definition (GO:0140774 GONUTS page)

Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. PMID:23552949

520 annotations

Ancestor Chart

Ancestor chart for GO:0140774
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
RHEA 70563

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29969 L-lysinium residue
has_participant CHEBI CHEBI:138936 N(6)-hexadecanoyl-L-lysine residue
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:189673 2''-O-hexadecanoyl-ADP-D-ribose(2-)
has_participant CHEBI CHEBI:17154 nicotinamide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140774 based on ALL annotations
The top 100 of 198 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein demyristoylase activity
385,254.50 100.00 506 506
NAD-dependent protein depalmitoylase activity
385,254.50 100.00 506 506
cellular response to caloric restriction
360,399.40 16.99 87 93
positive regulation of blood vessel branching
133,809.77 13.44 91 262
DNA damage sensor activity
115,076.02 12.74 92 308
positive regulation of oocyte maturation
117,488.96 12.25 86 282
NLRP3 inflammasome complex assembly
87,463.19 10.61 84 370
negative regulation of protein localization to chromatin
76,546.20 10.42 91 458
positive regulation of attachment of spindle microtubules to kinetochore
72,025.84 9.77 86 460
negative regulation of striated muscle tissue development
67,204.64 9.42 86 493
Totals 10584 935170
No co-occurrence statistics for GO:0140774 based on MANUAL annotations
The top 100 of 175 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein demyristoylase activity
99,369.16 100.00 13 13
NAD-dependent protein depalmitoylase activity
99,369.16 100.00 13 13
histone H3K56 deacetylase activity, NAD-dependent
86,948.02 50.00 7 8
ketone biosynthetic process
86,948.02 50.00 7 8
negative regulation of oligodendrocyte progenitor proliferation
99,369.16 46.15 6 6
cellular response to caloric restriction
74,526.87 40.00 6 8
NAD-dependent protein lysine deacetylase activity
30,041.84 30.23 13 43
tubulin deacetylation
55,205.09 29.41 5 9
NAD+-protein-arginine ADP-ribosyltransferase activity
36,609.69 28.00 7 19
DNA damage sensor activity
33,123.05 25.93 7 21
Totals 530 12268

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-08-12 Added XREF RHEA:70563
2022-03-06 Added RELATION part of GO:0043687 (post-translational protein modification)
2022-03-06 Added RELATION is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
2022-03-06 Added DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-03-06 Added TERM NAD-dependent protein depalmitoylase activity
Timestamp Action Category Detail
2022-03-06 Added TERM NAD-dependent protein depalmitoylase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
2022-03-06 Added DEFINITION Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.
Timestamp Action Category Detail
2022-03-06 Added RELATION part of GO:0043687 (post-translational protein modification)
2022-03-06 Added RELATION is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Timestamp Action Category Detail
2022-08-12 Added XREF RHEA:70563
Timestamp Action Category Detail
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