This term is obsolete.

GO:0140805 JSON

NAD+-protein-serine ADP-ribosyltransferase activity

Molecular Function

Definition (GO:0140805 GONUTS page)

Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. PMID:32028527 PMID:33186521

843 annotations

Ancestor Chart

Ancestor chart for GO:0140805
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140805

Child Term Relationship to
GO:0140805
NAD+-histone H3S10 serine ADP-ribosyltransferase activity
is_a
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q3UPF5 10090 ZCCHV_MOUSE GO:1990404 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q6AYL7 10116 Q6AYL7_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7JRM5 7227 Q7JRM5_DROME GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
RHEA 58232

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:29999 L-serine residue
has_participant CHEBI CHEBI:142556 O-(ADP-D-ribosyl)-L-serine(2-) residue
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0018127 obsolete NAD(P)-serine ADP-ribosyltransferase activity replaced_by GO:0140805

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140805 based on ALL annotations
The top 100 of 143 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD+-protein-serine ADP-ribosyltransferase activity
1,036,908.44 100.00 188 188
NAD DNA ADP-ribosyltransferase activity
697,769.20 65.09 179 266
DNA ADP-ribosylation
588,429.60 56.23 185 326
regulation of base-excision repair
1,036,908.50 51.60 97 97
NAD+-protein-glutamate ADP-ribosyltransferase activity
524,089.60 50.27 186 368
positive regulation of single strand break repair
555,284.30 35.90 98 183
negative regulation of ATP biosynthetic process
510,559.00 33.68 97 197
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
352,219.72 27.02 107 315
NAD+-histone H3S10 serine ADP-ribosyltransferase activity
352,219.72 27.02 107 315
NAD+-protein-histidine ADP-ribosyltransferase activity
345,636.16 26.26 104 312
Totals 6838 3470723
No co-occurrence statistics for GO:0140805 based on MANUAL annotations
The top 100 of 135 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD+-protein-serine ADP-ribosyltransferase activity
80,737.44 100.00 16 16
NAD+-protein-glutamate ADP-ribosyltransferase activity
55,048.25 65.22 15 22
NAD+-protein-histidine ADP-ribosyltransferase activity
80,737.44 56.25 9 9
NAD+-protein-tyrosine ADP-ribosyltransferase activity
80,737.44 56.25 9 9
DNA ADP-ribosylation
49,144.53 56.00 14 23
NAD+-protein-aspartate ADP-ribosyltransferase activity
37,845.67 45.45 15 32
NAD DNA ADP-ribosyltransferase activity
49,684.58 38.10 8 13
protein auto-ADP-ribosylation
22,019.30 26.79 15 55
regulation of circadian sleep/wake cycle, non-REM sleep
36,698.83 22.73 5 11
NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
80,737.44 18.75 3 3
Totals 462 44845

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
2022-05-07 Added DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
2022-05-07 Added TERM NAD+-protein-serine ADP-ribosyltransferase activity
2022-05-07 Added XREF RHEA:58232
2022-05-07 Added RELATION is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity)
Timestamp Action Category Detail
2022-05-07 Added TERM NAD+-protein-serine ADP-ribosyltransferase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
2022-05-07 Added DEFINITION Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein].
Timestamp Action Category Detail
2022-05-07 Added RELATION is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity)
Timestamp Action Category Detail
2022-05-07 Added XREF RHEA:58232
Timestamp Action Category Detail
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