GO:0140805
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NAD+-protein-serine ADP-ribosyltransferase activity
Molecular Function
Definition (GO:0140805 GONUTS page)
Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. PMID:32028527 PMID:33186521
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140805
Child Term | Relationship to GO:0140805 |
---|---|
NAD+-histone H3S10 serine ADP-ribosyltransferase activity
|
is_a |
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q3UPF5 | 10090 | ZCCHV_MOUSE | GO:1990404 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
RHEA | 58232 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
has_participant | CHEBI | CHEBI:29999 | L-serine residue |
has_participant | CHEBI | CHEBI:142556 | O-(ADP-D-ribosyl)-L-serine(2-) residue |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0018127 | obsolete NAD(P)-serine ADP-ribosyltransferase activity | replaced_by GO:0140805 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140805 based on ALL annotations
The top 100 of 143 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+-protein-serine ADP-ribosyltransferase activity
|
1,036,908.44 | 100.00 | 188 | 188 |
NAD DNA ADP-ribosyltransferase activity
|
697,769.20 | 65.09 | 179 | 266 |
DNA ADP-ribosylation
|
588,429.60 | 56.23 | 185 | 326 |
regulation of base-excision repair
|
1,036,908.50 | 51.60 | 97 | 97 |
NAD+-protein-glutamate ADP-ribosyltransferase activity
|
524,089.60 | 50.27 | 186 | 368 |
positive regulation of single strand break repair
|
555,284.30 | 35.90 | 98 | 183 |
negative regulation of ATP biosynthetic process
|
510,559.00 | 33.68 | 97 | 197 |
NAD+-histone H2BS6 serine ADP-ribosyltransferase activity
|
352,219.72 | 27.02 | 107 | 315 |
NAD+-histone H3S10 serine ADP-ribosyltransferase activity
|
352,219.72 | 27.02 | 107 | 315 |
NAD+-protein-histidine ADP-ribosyltransferase activity
|
345,636.16 | 26.26 | 104 | 312 |
Totals | 6838 | 3470723 |
No co-occurrence statistics for GO:0140805 based on MANUAL annotations
The top 100 of 135 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+-protein-serine ADP-ribosyltransferase activity
|
80,737.44 | 100.00 | 16 | 16 |
NAD+-protein-glutamate ADP-ribosyltransferase activity
|
55,048.25 | 65.22 | 15 | 22 |
NAD+-protein-histidine ADP-ribosyltransferase activity
|
80,737.44 | 56.25 | 9 | 9 |
NAD+-protein-tyrosine ADP-ribosyltransferase activity
|
80,737.44 | 56.25 | 9 | 9 |
DNA ADP-ribosylation
|
49,144.53 | 56.00 | 14 | 23 |
NAD+-protein-aspartate ADP-ribosyltransferase activity
|
37,845.67 | 45.45 | 15 | 32 |
NAD DNA ADP-ribosyltransferase activity
|
49,684.58 | 38.10 | 8 | 13 |
protein auto-ADP-ribosylation
|
22,019.30 | 26.79 | 15 | 55 |
regulation of circadian sleep/wake cycle, non-REM sleep
|
36,698.83 | 22.73 | 5 | 11 |
NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
|
80,737.44 | 18.75 | 3 | 3 |
Totals | 462 | 44845 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
2022-05-07 | Added | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
2022-05-07 | Added | TERM | NAD+-protein-serine ADP-ribosyltransferase activity |
2022-05-07 | Added | XREF | RHEA:58232 |
2022-05-07 | Added | RELATION | is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-07 | Added | TERM | NAD+-protein-serine ADP-ribosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
2022-05-07 | Added | DEFINITION | Catalysis of the reaction: L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-07 | Added | RELATION | is a GO:1990404 (NAD+-protein ADP-ribosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-07 | Added | XREF | RHEA:58232 |
Timestamp | Action | Category | Detail |
---|
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