This term is obsolete.
Drosophila H2AV corresponds to histone H2AZ.

GO:0140849 JSON

ATP-dependent H2AZ histone chaperone activity

Molecular Function

Definition (GO:0140849 GONUTS page)

A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite. PMID:21241891 PMID:23580526 PMID:30309918

Comments

Drosophila H2AV corresponds to histone H2AZ.

1,348 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
H2AZ histone exchange activity related
ATP-dependent H2A.Z histone chaperone activity exact

Ancestor Chart

Ancestor chart for GO:0140849
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
InterPro IPR008895 Vps72/YL1 family
InterPro IPR037651 SWR1-complex protein 3
RHEA 13065

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:43474 hydrogenphosphate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140849 based on ALL annotations
The top 38 of 38 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent H2AZ histone chaperone activity
146,999.16 100.00 1,348 1,348
Swr1 complex
10,330.79 7.03 1,348 19,181
chromatin remodeling
213.48 0.15 1,348 928,208
endoplasmic reticulum organization
116.42 0.07 14 17,677
histamine receptor activity
37.81 0.02 1 3,888
toxin transmembrane transporter activity
26.28 0.02 2 11,186
molecular_function
12.69 0.01 6 69,480
transcription initiation-coupled chromatin remodeling
12.68 0.01 1 11,596
bacteriocin transport
9.57 0.01 2 30,724
cellular_component
7.05 0.00 3 62,590
Totals 4348 196089139
No co-occurrence statistics for GO:0140849 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent H2AZ histone chaperone activity
1,411,533.00 100.00 1 1
transcription initiation-coupled chromatin remodeling
2,922.43 0.21 1 483
Swr1 complex
1,607.67 0.11 1 878
histone binding
231.82 0.02 1 6,089
chromatin remodeling
223.70 0.02 1 6,310
ATP binding
206.09 0.01 1 6,849
ATP hydrolysis activity
130.75 0.01 1 10,796
DNA binding
109.19 0.01 1 12,927
nucleus
6.78 0.00 1 208,176
Totals 9 252509

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF RHEA:13065
2023-01-16 Deleted DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers dimers and remove H2A-H2B, while others do the opposite.
2023-01-16 Added DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.
2022-07-18 Added DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers dimers and remove H2A-H2B, while others do the opposite.
2022-07-18 Deleted DEFINITION A histone chaperone that unloads histone H2A-H2B dimer and deposits a variant histone H2AZ-H2B dimer instead into a nucleosome, driven by ATP hydrolysis.
2022-06-12 Added TERM ATP-dependent H2AZ histone chaperone activity
2022-06-12 Added DEFINITION A histone chaperone that unloads histone H2A-H2B dimer and deposits a variant histone H2AZ-H2B dimer instead into a nucleosome, driven by ATP hydrolysis.
2022-06-12 Added RELATION is a GO:0140674 (ATP-dependent histone chaperone activity)
2022-06-12 Added SYNONYM H2AZ histone exchange activity
2022-06-12 Added SYNONYM ATP-dependent H2A.Z histone chaperone activity
Timestamp Action Category Detail
2022-06-12 Added TERM ATP-dependent H2AZ histone chaperone activity
Timestamp Action Category Detail
2023-01-16 Deleted DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers dimers and remove H2A-H2B, while others do the opposite.
2023-01-16 Added DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite.
2022-07-18 Added DEFINITION A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers dimers and remove H2A-H2B, while others do the opposite.
2022-07-18 Deleted DEFINITION A histone chaperone that unloads histone H2A-H2B dimer and deposits a variant histone H2AZ-H2B dimer instead into a nucleosome, driven by ATP hydrolysis.
2022-06-12 Added DEFINITION A histone chaperone that unloads histone H2A-H2B dimer and deposits a variant histone H2AZ-H2B dimer instead into a nucleosome, driven by ATP hydrolysis.
2022-06-12 Added SYNONYM H2AZ histone exchange activity
2022-06-12 Added SYNONYM ATP-dependent H2A.Z histone chaperone activity
Timestamp Action Category Detail
2022-06-12 Added RELATION is a GO:0140674 (ATP-dependent histone chaperone activity)
Timestamp Action Category Detail
2024-08-16 Added XREF RHEA:13065
Timestamp Action Category Detail
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