GO:0140853
JSON
cholesterol-protein transferase activity
Molecular Function
Definition (GO:0140853 GONUTS page)
Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]. PMID:8824192
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cholesterol transferase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
RHEA | 59504 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:16113 | cholesterol |
has_participant | CHEBI | CHEBI:65250 | L-cysteiniumyl group |
has_participant | CHEBI | CHEBI:143140 | glycyl-L-cysteine residue |
has_participant | CHEBI | CHEBI:143135 | Glycino 3beta-cholesterol ester group |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140853 based on ALL annotations
The top 100 of 415 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cholesterol-protein transferase activity
|
1,788,429.20 | 100.00 | 109 | 109 |
positive regulation of kidney smooth muscle cell differentiation
|
1,788,429.20 | 71.56 | 78 | 78 |
negative regulation of kidney smooth muscle cell differentiation
|
1,788,429.20 | 71.56 | 78 | 78 |
positive regulation of ureter smooth muscle cell differentiation
|
1,788,429.20 | 71.56 | 78 | 78 |
negative regulation of ureter smooth muscle cell differentiation
|
1,788,429.20 | 71.56 | 78 | 78 |
left lung development
|
1,788,429.20 | 71.56 | 78 | 78 |
right lung development
|
1,788,429.20 | 71.56 | 78 | 78 |
tracheoesophageal septum formation
|
1,788,429.20 | 71.56 | 78 | 78 |
cell proliferation in external granule layer
|
1,788,429.20 | 71.56 | 78 | 78 |
regulation of mesenchymal cell proliferation involved in prostate gland development
|
1,788,429.20 | 71.56 | 78 | 78 |
Totals | 7445 | 61870 |
No co-occurrence statistics for GO:0140853 based on MANUAL annotations
The top 100 of 400 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cholesterol-protein transferase activity
|
41,670.93 | 100.00 | 31 | 31 |
self proteolysis
|
11,431.85 | 27.43 | 31 | 113 |
cell-cell signaling involved in cell fate commitment
|
9,804.93 | 17.14 | 12 | 51 |
segment polarity determination
|
6,945.16 | 13.19 | 12 | 72 |
negative regulation of alpha-beta T cell differentiation
|
16,668.37 | 10.81 | 4 | 10 |
positive regulation of kidney smooth muscle cell differentiation
|
41,670.93 | 9.68 | 3 | 3 |
negative regulation of kidney smooth muscle cell differentiation
|
41,670.93 | 9.68 | 3 | 3 |
positive regulation of ureter smooth muscle cell differentiation
|
41,670.93 | 9.68 | 3 | 3 |
negative regulation of ureter smooth muscle cell differentiation
|
41,670.93 | 9.68 | 3 | 3 |
patched binding
|
4,415.46 | 9.64 | 16 | 151 |
Totals | 324 | 2451 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | XREF | RHEA:59504 |
2024-03-21 | Added | DEFINITION | Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]. |
2024-03-21 | Deleted | DEFINITION | Catalysis of the transfer of a cholesterol to an acceptor protein. |
2022-06-16 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2022-06-16 | Added | RELATION | is a GO:0016740 (transferase activity) |
2022-06-16 | Added | SYNONYM | cholesterol transferase activity |
2022-06-16 | Added | DEFINITION | Catalysis of the transfer of a cholesterol to an acceptor protein. |
2022-06-16 | Added | TERM | cholesterol-protein transferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-16 | Added | TERM | cholesterol-protein transferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | DEFINITION | Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]. |
2024-03-21 | Deleted | DEFINITION | Catalysis of the transfer of a cholesterol to an acceptor protein. |
2022-06-16 | Added | SYNONYM | cholesterol transferase activity |
2022-06-16 | Added | DEFINITION | Catalysis of the transfer of a cholesterol to an acceptor protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-16 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2022-06-16 | Added | RELATION | is a GO:0016740 (transferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | XREF | RHEA:59504 |
Timestamp | Action | Category | Detail |
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