This term is obsolete.

GO:0140853 JSON

cholesterol-protein transferase activity

Molecular Function

Definition (GO:0140853 GONUTS page)

Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]. PMID:8824192

111 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cholesterol transferase activity broad

Ancestor Chart

Ancestor chart for GO:0140853
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
RHEA 59504

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:16113 cholesterol
has_participant CHEBI CHEBI:65250 L-cysteiniumyl group
has_participant CHEBI CHEBI:143140 glycyl-L-cysteine residue
has_participant CHEBI CHEBI:143135 Glycino 3beta-cholesterol ester group
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140853 based on ALL annotations
The top 100 of 415 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cholesterol-protein transferase activity
1,788,429.20 100.00 109 109
positive regulation of kidney smooth muscle cell differentiation
1,788,429.20 71.56 78 78
negative regulation of kidney smooth muscle cell differentiation
1,788,429.20 71.56 78 78
positive regulation of ureter smooth muscle cell differentiation
1,788,429.20 71.56 78 78
negative regulation of ureter smooth muscle cell differentiation
1,788,429.20 71.56 78 78
left lung development
1,788,429.20 71.56 78 78
right lung development
1,788,429.20 71.56 78 78
tracheoesophageal septum formation
1,788,429.20 71.56 78 78
cell proliferation in external granule layer
1,788,429.20 71.56 78 78
regulation of mesenchymal cell proliferation involved in prostate gland development
1,788,429.20 71.56 78 78
Totals 7445 61870
No co-occurrence statistics for GO:0140853 based on MANUAL annotations
The top 100 of 400 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cholesterol-protein transferase activity
41,670.93 100.00 31 31
self proteolysis
11,431.85 27.43 31 113
cell-cell signaling involved in cell fate commitment
9,804.93 17.14 12 51
segment polarity determination
6,945.16 13.19 12 72
negative regulation of alpha-beta T cell differentiation
16,668.37 10.81 4 10
positive regulation of kidney smooth muscle cell differentiation
41,670.93 9.68 3 3
negative regulation of kidney smooth muscle cell differentiation
41,670.93 9.68 3 3
positive regulation of ureter smooth muscle cell differentiation
41,670.93 9.68 3 3
negative regulation of ureter smooth muscle cell differentiation
41,670.93 9.68 3 3
patched binding
4,415.46 9.64 16 151
Totals 324 2451

Change Log

Timestamp Action Category Detail
2024-03-21 Added XREF RHEA:59504
2024-03-21 Added DEFINITION Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein].
2024-03-21 Deleted DEFINITION Catalysis of the transfer of a cholesterol to an acceptor protein.
2022-06-16 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2022-06-16 Added RELATION is a GO:0016740 (transferase activity)
2022-06-16 Added SYNONYM cholesterol transferase activity
2022-06-16 Added DEFINITION Catalysis of the transfer of a cholesterol to an acceptor protein.
2022-06-16 Added TERM cholesterol-protein transferase activity
Timestamp Action Category Detail
2022-06-16 Added TERM cholesterol-protein transferase activity
Timestamp Action Category Detail
2024-03-21 Added DEFINITION Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein].
2024-03-21 Deleted DEFINITION Catalysis of the transfer of a cholesterol to an acceptor protein.
2022-06-16 Added SYNONYM cholesterol transferase activity
2022-06-16 Added DEFINITION Catalysis of the transfer of a cholesterol to an acceptor protein.
Timestamp Action Category Detail
2022-06-16 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2022-06-16 Added RELATION is a GO:0016740 (transferase activity)
Timestamp Action Category Detail
2024-03-21 Added XREF RHEA:59504
Timestamp Action Category Detail
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