GO:0140939
JSON
histone H4 methyltransferase activity
Molecular Function
Definition (GO:0140939 GONUTS page)
Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. PMID:28450737
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
histone H4 methylation | exact |
histone H4 methylase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140939
Child Term | Relationship to GO:0140939 |
---|---|
histone H4K12 methyltransferase activity
|
is_a |
histone H4K20 methyltransferase activity
|
is_a |
histone H4R3 methyltransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR025805 | Histone-lysine N-methyltransferase SMYD3 |
Reactome | R-HSA-5423038 | |
Reactome | R-HSA-5651654 | |
Reactome | R-HSA-5651657 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0018024 | obsolete histone lysine N-methyltransferase activity | consider GO:0140939 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140939 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H4 methyltransferase activity
|
585,401.75 | 100.00 | 333 | 333 |
regulation of modification of postsynaptic actin cytoskeleton
|
193,632.89 | 16.96 | 86 | 260 |
histone H3K36 dimethyltransferase activity
|
226,259.58 | 14.55 | 63 | 163 |
myotube cell development
|
95,544.84 | 9.60 | 63 | 386 |
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
|
58,914.23 | 7.03 | 63 | 626 |
genomic imprinting
|
36,961.63 | 5.55 | 105 | 1,663 |
protein-arginine omega-N monomethyltransferase activity
|
15,004.70 | 2.52 | 206 | 8,037 |
histone H3K27 monomethyltransferase activity
|
390,267.84 | 2.37 | 8 | 12 |
histone H3K9 dimethyltransferase activity
|
246,484.95 | 2.33 | 8 | 19 |
histone H3K9 monomethyltransferase activity
|
173,452.38 | 2.27 | 8 | 27 |
Totals | 5051 | 26560068 |
No co-occurrence statistics for GO:0140939 based on MANUAL annotations
The top 91 of 91 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H4 methyltransferase activity
|
71,766.61 | 100.00 | 18 | 18 |
histone H3K36 dimethyltransferase activity
|
25,630.93 | 18.52 | 5 | 14 |
myotube cell development
|
11,482.66 | 10.26 | 4 | 25 |
peptidyl-arginine methylation
|
9,698.19 | 10.00 | 5 | 37 |
histone H4R3 methyltransferase activity
|
7,360.68 | 7.55 | 4 | 39 |
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
|
6,240.58 | 6.67 | 4 | 46 |
protein-arginine omega-N monomethyltransferase activity
|
4,865.53 | 6.25 | 8 | 118 |
histone H3K27 monomethyltransferase activity
|
71,766.61 | 5.56 | 1 | 1 |
histone H3K9 monomethyltransferase activity
|
71,766.61 | 5.56 | 1 | 1 |
histone H2A methyltransferase activity
|
35,883.31 | 5.26 | 1 | 2 |
Totals | 258 | 957697 |
Change Log
- All changes
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-11-01 | Added | XREF | Reactome:R-HSA-5423038 |
2023-11-01 | Added | XREF | Reactome:R-HSA-5651657 |
2023-11-01 | Added | XREF | Reactome:R-HSA-5651654 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5651657 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5423038 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5651654 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-5651654 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | TERM | histone H4 methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-16 | Deleted | SYNONYM | histone H4 methylation |
2023-01-16 | Added | SYNONYM | histone H4 methylation |
2022-11-08 | Added | DEFINITION | Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. |
2022-11-08 | Added | SYNONYM | histone H4 methylation |
2022-11-08 | Added | SYNONYM | histone H4 methylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | RELATION | is a GO:0042054 (histone methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-11-01 | Added | XREF | Reactome:R-HSA-5423038 |
2023-11-01 | Added | XREF | Reactome:R-HSA-5651657 |
2023-11-01 | Added | XREF | Reactome:R-HSA-5651654 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5651657 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5423038 |
2023-10-23 | Added | XREF | Reactome:R-HSA-5651654 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-08-28 | Added | XREF | Reactome:R-HSA-5423038 |
2023-08-28 | Added | XREF | Reactome:R-HSA-5651654 |
2023-08-28 | Added | XREF | Reactome:R-HSA-5651657 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-08-14 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-08-12 | Added | XREF | Reactome:R-HSA-5651657 |
2023-08-12 | Added | XREF | Reactome:R-HSA-5423038 |
2023-08-12 | Added | XREF | Reactome:R-HSA-5651654 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-08-11 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-07-26 | Added | XREF | Reactome:R-HSA-5651657 |
2023-07-26 | Added | XREF | Reactome:R-HSA-5651654 |
2023-07-26 | Added | XREF | Reactome:R-HSA-5423038 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-07-24 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-07-14 | Added | XREF | Reactome:R-HSA-5651657 |
2023-07-14 | Added | XREF | Reactome:R-HSA-5423038 |
2023-07-14 | Added | XREF | Reactome:R-HSA-5651654 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-07-12 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-07-10 | Added | XREF | Reactome:R-HSA-5651654 |
2023-07-10 | Added | XREF | Reactome:R-HSA-5651657 |
2023-07-10 | Added | XREF | Reactome:R-HSA-5423038 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-07-08 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-06-24 | Added | XREF | Reactome:R-HSA-5651654 |
2023-06-24 | Added | XREF | Reactome:R-HSA-5651657 |
2023-06-24 | Added | XREF | Reactome:R-HSA-5423038 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-5651657 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-5423038 |
2023-06-18 | Deleted | XREF | Reactome:R-HSA-5651654 |
2023-06-13 | Added | XREF | Reactome:R-HSA-5651654 |
2023-06-13 | Added | XREF | Reactome:R-HSA-5423038 |
2023-06-13 | Added | XREF | Reactome:R-HSA-5651657 |
Timestamp | Action | Category | Detail |
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