This term is obsolete.

GO:0140939 JSON

histone H4 methyltransferase activity

Molecular Function

Definition (GO:0140939 GONUTS page)

Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. PMID:28450737

28,129 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histone H4 methylation exact
histone H4 methylase activity exact

Ancestor Chart

Ancestor chart for GO:0140939
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140939

Child Term Relationship to
GO:0140939
histone H4K12 methyltransferase activity
is_a
histone H4K20 methyltransferase activity
is_a
histone H4R3 methyltransferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR025805 Histone-lysine N-methyltransferase SMYD3
Reactome R-HSA-5423038
Reactome R-HSA-5651654
Reactome R-HSA-5651657

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0018024 obsolete histone lysine N-methyltransferase activity consider GO:0140939

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140939 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H4 methyltransferase activity
585,401.75 100.00 333 333
regulation of modification of postsynaptic actin cytoskeleton
193,632.89 16.96 86 260
histone H3K36 dimethyltransferase activity
226,259.58 14.55 63 163
myotube cell development
95,544.84 9.60 63 386
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
58,914.23 7.03 63 626
genomic imprinting
36,961.63 5.55 105 1,663
protein-arginine omega-N monomethyltransferase activity
15,004.70 2.52 206 8,037
histone H3K27 monomethyltransferase activity
390,267.84 2.37 8 12
histone H3K9 dimethyltransferase activity
246,484.95 2.33 8 19
histone H3K9 monomethyltransferase activity
173,452.38 2.27 8 27
Totals 5051 26560068
No co-occurrence statistics for GO:0140939 based on MANUAL annotations
The top 91 of 91 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H4 methyltransferase activity
71,766.61 100.00 18 18
histone H3K36 dimethyltransferase activity
25,630.93 18.52 5 14
myotube cell development
11,482.66 10.26 4 25
peptidyl-arginine methylation
9,698.19 10.00 5 37
histone H4R3 methyltransferase activity
7,360.68 7.55 4 39
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
6,240.58 6.67 4 46
protein-arginine omega-N monomethyltransferase activity
4,865.53 6.25 8 118
histone H3K27 monomethyltransferase activity
71,766.61 5.56 1 1
histone H3K9 monomethyltransferase activity
71,766.61 5.56 1 1
histone H2A methyltransferase activity
35,883.31 5.26 1 2
Totals 258 957697

Change Log

Timestamp Action Category Detail
2023-11-01 Added XREF Reactome:R-HSA-5423038
2023-11-01 Added XREF Reactome:R-HSA-5651657
2023-11-01 Added XREF Reactome:R-HSA-5651654
2023-10-28 Deleted XREF Reactome:R-HSA-5651654
2023-10-28 Deleted XREF Reactome:R-HSA-5423038
2023-10-28 Deleted XREF Reactome:R-HSA-5651657
2023-10-23 Added XREF Reactome:R-HSA-5651657
2023-10-23 Added XREF Reactome:R-HSA-5423038
2023-10-23 Added XREF Reactome:R-HSA-5651654
2023-10-10 Deleted XREF Reactome:R-HSA-5651654
Timestamp Action Category Detail
2022-11-08 Added TERM histone H4 methyltransferase activity
Timestamp Action Category Detail
2023-01-16 Deleted SYNONYM histone H4 methylation
2023-01-16 Added SYNONYM histone H4 methylation
2022-11-08 Added DEFINITION Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue.
2022-11-08 Added SYNONYM histone H4 methylation
2022-11-08 Added SYNONYM histone H4 methylase activity
Timestamp Action Category Detail
2022-11-08 Added RELATION is a GO:0042054 (histone methyltransferase activity)
Timestamp Action Category Detail
2023-11-01 Added XREF Reactome:R-HSA-5423038
2023-11-01 Added XREF Reactome:R-HSA-5651657
2023-11-01 Added XREF Reactome:R-HSA-5651654
2023-10-28 Deleted XREF Reactome:R-HSA-5651654
2023-10-28 Deleted XREF Reactome:R-HSA-5423038
2023-10-28 Deleted XREF Reactome:R-HSA-5651657
2023-10-23 Added XREF Reactome:R-HSA-5651657
2023-10-23 Added XREF Reactome:R-HSA-5423038
2023-10-23 Added XREF Reactome:R-HSA-5651654
2023-10-10 Deleted XREF Reactome:R-HSA-5651654
2023-10-10 Deleted XREF Reactome:R-HSA-5651657
2023-10-10 Deleted XREF Reactome:R-HSA-5423038
2023-08-28 Added XREF Reactome:R-HSA-5423038
2023-08-28 Added XREF Reactome:R-HSA-5651654
2023-08-28 Added XREF Reactome:R-HSA-5651657
2023-08-14 Deleted XREF Reactome:R-HSA-5423038
2023-08-14 Deleted XREF Reactome:R-HSA-5651654
2023-08-14 Deleted XREF Reactome:R-HSA-5651657
2023-08-12 Added XREF Reactome:R-HSA-5651657
2023-08-12 Added XREF Reactome:R-HSA-5423038
2023-08-12 Added XREF Reactome:R-HSA-5651654
2023-08-11 Deleted XREF Reactome:R-HSA-5651657
2023-08-11 Deleted XREF Reactome:R-HSA-5423038
2023-08-11 Deleted XREF Reactome:R-HSA-5651654
2023-07-26 Added XREF Reactome:R-HSA-5651657
2023-07-26 Added XREF Reactome:R-HSA-5651654
2023-07-26 Added XREF Reactome:R-HSA-5423038
2023-07-24 Deleted XREF Reactome:R-HSA-5651654
2023-07-24 Deleted XREF Reactome:R-HSA-5651657
2023-07-24 Deleted XREF Reactome:R-HSA-5423038
2023-07-14 Added XREF Reactome:R-HSA-5651657
2023-07-14 Added XREF Reactome:R-HSA-5423038
2023-07-14 Added XREF Reactome:R-HSA-5651654
2023-07-12 Deleted XREF Reactome:R-HSA-5423038
2023-07-12 Deleted XREF Reactome:R-HSA-5651654
2023-07-12 Deleted XREF Reactome:R-HSA-5651657
2023-07-10 Added XREF Reactome:R-HSA-5651654
2023-07-10 Added XREF Reactome:R-HSA-5651657
2023-07-10 Added XREF Reactome:R-HSA-5423038
2023-07-08 Deleted XREF Reactome:R-HSA-5423038
2023-07-08 Deleted XREF Reactome:R-HSA-5651654
2023-07-08 Deleted XREF Reactome:R-HSA-5651657
2023-06-24 Added XREF Reactome:R-HSA-5651654
2023-06-24 Added XREF Reactome:R-HSA-5651657
2023-06-24 Added XREF Reactome:R-HSA-5423038
2023-06-18 Deleted XREF Reactome:R-HSA-5651657
2023-06-18 Deleted XREF Reactome:R-HSA-5423038
2023-06-18 Deleted XREF Reactome:R-HSA-5651654
2023-06-13 Added XREF Reactome:R-HSA-5651654
2023-06-13 Added XREF Reactome:R-HSA-5423038
2023-06-13 Added XREF Reactome:R-HSA-5651657
Timestamp Action Category Detail
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