GO:0140952
JSON
histone H3K27 dimethyltransferase activity
Molecular Function
Definition (GO:0140952 GONUTS page)
Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| histone lysine N-dimethyltransferase activity (H3-K27 specific) | exact |
| histone H3-K27 dimethylase activity | exact |
| histone H3K27 dimethylase activity | exact |
| histone H3K27 mono/dimethylase activity | exact |
| histone H3-K27 dimethylation | broad |
| histone H3K27 dimethylation | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A0A0G2JWF0 | 10116 | A0A0G2JWF0_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I5ZVR7 | 10116 | A0A8I5ZVR7_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I6A251 | 10116 | A0A8I6A251_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I6ASP1 | 10116 | A0A8I6ASP1_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | A6IBP2 | 10116 | A6IBP2_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6IBP3 | 10116 | A6IBP3_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
| Database | ID | Description |
|---|---|---|
| EC | 2.1.1.371 | |
| RHEA | 64452 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
| has_participant | CHEBI | CHEBI:61976 | N(6),N(6)-dimethyl-L-lysine(1+) residue |
| has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
| has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
| has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140952 based on ALL annotations
The top of co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
| Totals | 0 | 0 | ||
No co-occurrence statistics for GO:0140952 based on MANUAL annotations
The top of co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
| Totals | 0 | 0 | ||
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-11-08 | Added | SYNONYM | histone H3-K27 dimethylase activity |
| 2022-11-08 | Added | SYNONYM | histone H3-K27 dimethylation |
| 2022-11-08 | Added | SYNONYM | histone H3K27 dimethylation |
| 2022-11-08 | Added | SYNONYM | histone H3K27 mono/dimethylase activity |
| 2022-11-08 | Added | RELATION | is a GO:0046976 (histone H3K27 methyltransferase activity) |
| 2022-11-08 | Added | SYNONYM | histone H3K27 dimethylase activity |
| 2022-11-08 | Added | XREF | EC:2.1.1.371 |
| 2022-11-08 | Added | XREF | RHEA:64452 |
| 2022-11-08 | Added | DEFINITION | Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2. |
| 2022-11-08 | Added | TERM | histone H3K27 dimethyltransferase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-11-08 | Added | TERM | histone H3K27 dimethyltransferase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-11-08 | Added | SYNONYM | histone H3-K27 dimethylase activity |
| 2022-11-08 | Added | SYNONYM | histone H3-K27 dimethylation |
| 2022-11-08 | Added | SYNONYM | histone H3K27 dimethylation |
| 2022-11-08 | Added | SYNONYM | histone H3K27 mono/dimethylase activity |
| 2022-11-08 | Added | SYNONYM | histone H3K27 dimethylase activity |
| 2022-11-08 | Added | DEFINITION | Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2. |
| 2022-11-08 | Added | SYNONYM | histone lysine N-dimethyltransferase activity (H3-K27 specific) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-11-08 | Added | RELATION | is a GO:0046976 (histone H3K27 methyltransferase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-11-08 | Added | XREF | EC:2.1.1.371 |
| 2022-11-08 | Added | XREF | RHEA:64452 |
| Timestamp | Action | Category | Detail |
|---|
Please Wait...
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link