This term is obsolete.

GO:0140952 JSON

histone H3K27 dimethyltransferase activity

Molecular Function

Definition (GO:0140952 GONUTS page)

Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.

102 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histone H3-K27 dimethylation broad
histone H3K27 dimethylation broad
histone H3K27 dimethylase activity exact
histone H3-K27 dimethylase activity exact
histone lysine N-dimethyltransferase activity (H3-K27 specific) exact
histone H3K27 mono/dimethylase activity exact

Ancestor Chart

Ancestor chart for GO:0140952
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JWF0 10116 A0A0G2JWF0_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZVR7 10116 A0A8I5ZVR7_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A251 10116 A0A8I6A251_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ASP1 10116 A0A8I6ASP1_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6IBP2 10116 A6IBP2_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IBP3 10116 A6IBP3_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 2.1.1.371
RHEA 64452

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:29969 L-lysinium residue
has_participant CHEBI CHEBI:61976 N(6),N(6)-dimethyl-L-lysine(1+) residue
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140952 based on ALL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H3K27 dimethyltransferase activity
1,949,387.90 100.00 100 100
histone H3K4 dimethyltransferase activity
1,446,320.00 69.70 92 124
histone H3K27 monomethyltransferase activity
1,299,591.90 7.69 8 12
histone H3K9 dimethyltransferase activity
820,794.80 7.21 8 19
histone H3K9 monomethyltransferase activity
577,596.40 6.72 8 27
transcription regulator activator activity
110,871.44 5.66 91 1,600
histone H3K27 trimethyltransferase activity
54,088.95 2.77 99 3,568
histone H4 methyltransferase activity
46,832.14 1.88 8 333
polytene chromosome interband
39,282.38 1.64 8 397
facultative heterochromatin formation
37,219.82 1.57 8 419
Totals 1715 112298105
No co-occurrence statistics for GO:0140952 based on MANUAL annotations
The top 34 of 34 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H3K27 dimethyltransferase activity
161,474.88 100.00 8 8
histone H3K27 trimethyltransferase activity
143,533.22 88.89 8 9
histone H3K4 dimethyltransferase activity
102,756.73 58.33 7 11
transcription regulator activator activity
23,548.42 14.29 7 48
histone H3K27 monomethyltransferase activity
161,474.88 12.50 1 1
histone H3K9 monomethyltransferase activity
161,474.88 12.50 1 1
histone H3K9 dimethyltransferase activity
53,824.96 10.00 1 3
histone H3K9 trimethyltransferase activity
10,092.18 4.35 1 16
histone H4 methyltransferase activity
8,970.83 4.00 1 18
histone H3K27 methyltransferase activity
3,922.47 2.41 6 247
Totals 118 388004

Change Log

Timestamp Action Category Detail
2022-11-08 Added DEFINITION Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
2022-11-08 Added TERM histone H3K27 dimethyltransferase activity
2022-11-08 Added RELATION is a GO:0046976 (histone H3K27 methyltransferase activity)
2022-11-08 Added XREF EC:2.1.1.371
2022-11-08 Added XREF RHEA:64452
2022-11-08 Added SYNONYM histone H3K27 dimethylation
2022-11-08 Added SYNONYM histone H3-K27 dimethylation
2022-11-08 Added SYNONYM histone lysine N-dimethyltransferase activity (H3-K27 specific)
2022-11-08 Added SYNONYM histone H3-K27 dimethylase activity
2022-11-08 Added SYNONYM histone H3K27 dimethylase activity
Timestamp Action Category Detail
2022-11-08 Added TERM histone H3K27 dimethyltransferase activity
Timestamp Action Category Detail
2022-11-08 Added DEFINITION Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
2022-11-08 Added SYNONYM histone H3K27 dimethylation
2022-11-08 Added SYNONYM histone H3-K27 dimethylation
2022-11-08 Added SYNONYM histone lysine N-dimethyltransferase activity (H3-K27 specific)
2022-11-08 Added SYNONYM histone H3-K27 dimethylase activity
2022-11-08 Added SYNONYM histone H3K27 dimethylase activity
2022-11-08 Added SYNONYM histone H3K27 mono/dimethylase activity
Timestamp Action Category Detail
2022-11-08 Added RELATION is a GO:0046976 (histone H3K27 methyltransferase activity)
Timestamp Action Category Detail
2022-11-08 Added XREF EC:2.1.1.371
2022-11-08 Added XREF RHEA:64452
Timestamp Action Category Detail
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