GO:0140956
JSON
histone H3K79 trimethyltransferase activity
Molecular Function
Definition (GO:0140956 GONUTS page)
Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3. PMID:15371351
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
histone trimethyltransferase activity (H3-K79 specific) | exact |
histone lysine N-trimethyltransferase activity (H3-K79 specific) | exact |
histone H3K79 trimethylation | broad |
histone-H3K79 trimethyltransferase activity | exact |
histone H3-K79 trimethylation | broad |
histone H3K79 trimethylase activity | exact |
histone trimethylase activity (H3-K79 specific) | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0G2JWF0 | 10116 | A0A0G2JWF0_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZVR7 | 10116 | A0A8I5ZVR7_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A251 | 10116 | A0A8I6A251_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ASP1 | 10116 | A0A8I6ASP1_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6IBP2 | 10116 | A6IBP2_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IBP3 | 10116 | A6IBP3_RAT | GO:0140938 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.360 | |
RHEA | 60328 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:61961 | N(6),N(6),N(6)-trimethyl-L-lysine residue |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140956 based on ALL annotations
The top 100 of 188 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
histone H3K79 trimethyltransferase activity
|
63,643.09 | 100.00 | 3,063 | 3,063 |
histone H3K79 methyltransferase activity
|
27,583.18 | 43.33 | 3,062 | 7,065 |
histone H3 methyltransferase activity
|
5,365.64 | 7.95 | 1,787 | 21,196 |
DNA damage checkpoint signaling
|
4,084.45 | 6.35 | 2,647 | 41,245 |
subtelomeric heterochromatin formation
|
4,362.08 | 5.69 | 766 | 11,176 |
regulation of cell cycle
|
1,153.53 | 1.80 | 2,265 | 124,966 |
intestinal epithelial structure maintenance
|
3,688.21 | 1.14 | 43 | 742 |
chromosome, telomeric region
|
741.85 | 1.13 | 766 | 65,715 |
regulation of receptor signaling pathway via JAK-STAT
|
2,274.70 | 1.09 | 47 | 1,315 |
heterochromatin formation
|
612.74 | 0.90 | 381 | 39,573 |
Totals | 33399 | 27267402 |
No co-occurrence statistics for GO:0140956 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Totals | 0 | 0 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | DEFINITION | Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3. |
2022-11-08 | Added | TERM | histone H3K79 trimethyltransferase activity |
2022-11-08 | Added | RELATION | is a GO:0031151 (histone H3K79 methyltransferase activity) |
2022-11-08 | Added | XREF | EC:2.1.1.360 |
2022-11-08 | Added | XREF | RHEA:60328 |
2022-11-08 | Added | SYNONYM | histone trimethyltransferase activity (H3-K79 specific) |
2022-11-08 | Added | SYNONYM | histone lysine N-trimethyltransferase activity (H3-K79 specific) |
2022-11-08 | Added | SYNONYM | histone H3-K79 trimethylation |
2022-11-08 | Added | SYNONYM | histone H3K79 trimethylase activity |
2022-11-08 | Added | SYNONYM | histone-H3K79 trimethyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | TERM | histone H3K79 trimethyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | DEFINITION | Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3. |
2022-11-08 | Added | SYNONYM | histone trimethyltransferase activity (H3-K79 specific) |
2022-11-08 | Added | SYNONYM | histone lysine N-trimethyltransferase activity (H3-K79 specific) |
2022-11-08 | Added | SYNONYM | histone H3-K79 trimethylation |
2022-11-08 | Added | SYNONYM | histone H3K79 trimethylase activity |
2022-11-08 | Added | SYNONYM | histone-H3K79 trimethyltransferase activity |
2022-11-08 | Added | SYNONYM | histone trimethylase activity (H3-K79 specific) |
2022-11-08 | Added | SYNONYM | histone H3K79 trimethylation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | RELATION | is a GO:0031151 (histone H3K79 methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | XREF | EC:2.1.1.360 |
2022-11-08 | Added | XREF | RHEA:60328 |
Timestamp | Action | Category | Detail |
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