This term is obsolete.

GO:0140956 JSON

histone H3K79 trimethyltransferase activity

Molecular Function

Definition (GO:0140956 GONUTS page)

Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3. PMID:15371351

3,063 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histone trimethyltransferase activity (H3-K79 specific) exact
histone lysine N-trimethyltransferase activity (H3-K79 specific) exact
histone H3K79 trimethylation broad
histone-H3K79 trimethyltransferase activity exact
histone H3-K79 trimethylation broad
histone H3K79 trimethylase activity exact
histone trimethylase activity (H3-K79 specific) exact

Ancestor Chart

Ancestor chart for GO:0140956
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JWF0 10116 A0A0G2JWF0_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZVR7 10116 A0A8I5ZVR7_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A251 10116 A0A8I6A251_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ASP1 10116 A0A8I6ASP1_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6IBP2 10116 A6IBP2_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IBP3 10116 A6IBP3_RAT GO:0140938 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 2.1.1.360
RHEA 60328

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:61961 N(6),N(6),N(6)-trimethyl-L-lysine residue
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion
has_participant CHEBI CHEBI:29969 L-lysinium residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140956 based on ALL annotations
The top 100 of 188 co-occurring terms
Co-occurring Term PR S% #Together #Compared
histone H3K79 trimethyltransferase activity
63,643.09 100.00 3,063 3,063
histone H3K79 methyltransferase activity
27,583.18 43.33 3,062 7,065
histone H3 methyltransferase activity
5,365.64 7.95 1,787 21,196
DNA damage checkpoint signaling
4,084.45 6.35 2,647 41,245
subtelomeric heterochromatin formation
4,362.08 5.69 766 11,176
regulation of cell cycle
1,153.53 1.80 2,265 124,966
intestinal epithelial structure maintenance
3,688.21 1.14 43 742
chromosome, telomeric region
741.85 1.13 766 65,715
regulation of receptor signaling pathway via JAK-STAT
2,274.70 1.09 47 1,315
heterochromatin formation
612.74 0.90 381 39,573
Totals 33399 27267402
No co-occurrence statistics for GO:0140956 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Totals 0 0

Change Log

Timestamp Action Category Detail
2022-11-08 Added DEFINITION Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3.
2022-11-08 Added TERM histone H3K79 trimethyltransferase activity
2022-11-08 Added RELATION is a GO:0031151 (histone H3K79 methyltransferase activity)
2022-11-08 Added XREF EC:2.1.1.360
2022-11-08 Added XREF RHEA:60328
2022-11-08 Added SYNONYM histone trimethyltransferase activity (H3-K79 specific)
2022-11-08 Added SYNONYM histone lysine N-trimethyltransferase activity (H3-K79 specific)
2022-11-08 Added SYNONYM histone H3-K79 trimethylation
2022-11-08 Added SYNONYM histone H3K79 trimethylase activity
2022-11-08 Added SYNONYM histone-H3K79 trimethyltransferase activity
Timestamp Action Category Detail
2022-11-08 Added TERM histone H3K79 trimethyltransferase activity
Timestamp Action Category Detail
2022-11-08 Added DEFINITION Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3.
2022-11-08 Added SYNONYM histone trimethyltransferase activity (H3-K79 specific)
2022-11-08 Added SYNONYM histone lysine N-trimethyltransferase activity (H3-K79 specific)
2022-11-08 Added SYNONYM histone H3-K79 trimethylation
2022-11-08 Added SYNONYM histone H3K79 trimethylase activity
2022-11-08 Added SYNONYM histone-H3K79 trimethyltransferase activity
2022-11-08 Added SYNONYM histone trimethylase activity (H3-K79 specific)
2022-11-08 Added SYNONYM histone H3K79 trimethylation
Timestamp Action Category Detail
2022-11-08 Added RELATION is a GO:0031151 (histone H3K79 methyltransferase activity)
Timestamp Action Category Detail
2022-11-08 Added XREF EC:2.1.1.360
2022-11-08 Added XREF RHEA:60328
Timestamp Action Category Detail
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