This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0140981 JSON

medium-chain fatty acid omega-hydroxylase activity

Molecular Function

Definition (GO:0140981 GONUTS page)

Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

5 annotations

Ancestor Chart

Ancestor chart for GO:0140981
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
MetaCyc RXN-19719
RHEA 75279

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57618 FMNH2(2-)
has_participant CHEBI CHEBI:194241 omega-hydroxy-medium-chain fatty acid anion
has_participant CHEBI CHEBI:58210 FMN(3-)
has_participant CHEBI CHEBI:194240 omega-methyl-medium-chain fatty acid anion

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0102114 obsolete caprate dehydroxylase activity replaced_by GO:0140981
GO:0102116 obsolete laurate hydroxylase activity replaced_by GO:0140981

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140981 based on ALL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term PR S% #Together #Compared
16-hydroxypalmitate dehydrogenase activity
38,987,756.00 100.00 5 5
medium-chain fatty acid omega-hydroxylase activity
38,987,756.00 100.00 5 5
lauric acid metabolic process
822,526.56 2.11 5 237
lipid hydroxylation
735,618.00 1.89 5 265
arachidonate omega-hydroxylase activity
628,834.80 1.57 2 124
icosanoid biosynthetic process
603,525.60 1.55 5 323
long-chain fatty acid omega-hydroxylase activity
604,461.40 1.52 2 129
omega-hydroxylase P450 pathway
553,017.90 1.39 2 141
arachidonate monooxygenase activity
439,051.30 1.13 5 444
alkane 1-monooxygenase activity
139,043.36 0.36 5 1,402
Totals 113 89172855
No co-occurrence statistics for GO:0140981 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
16-hydroxypalmitate dehydrogenase activity
645,899.50 100.00 2 2
medium-chain fatty acid omega-hydroxylase activity
645,899.50 100.00 2 2
arachidonate omega-hydroxylase activity
143,533.22 22.22 2 9
lipid hydroxylation
80,737.44 12.50 2 16
lauric acid metabolic process
64,589.95 10.00 2 20
arachidonate monooxygenase activity
58,718.13 9.09 2 22
omega-hydroxylase P450 pathway
58,718.13 9.09 2 22
icosanoid biosynthetic process
46,135.68 7.14 2 28
alkane 1-monooxygenase activity
34,913.48 5.41 2 37
linoleic acid metabolic process
13,890.31 2.15 2 93
Totals 29 43873

Change Log

Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-06-13 Added XREF RHEA:75279
2023-01-18 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added XREF MetaCyc:RXN-19719
2023-01-16 Added TERM medium-chain fatty acid omega-hydroxylase activity
2023-01-16 Added RELATION is a GO:0120250 (fatty acid omega-hydroxylase activity)
Timestamp Action Category Detail
2023-01-16 Added TERM medium-chain fatty acid omega-hydroxylase activity
Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-01-18 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
Timestamp Action Category Detail
2023-01-16 Added RELATION is a GO:0120250 (fatty acid omega-hydroxylase activity)
Timestamp Action Category Detail
2023-06-13 Added XREF RHEA:75279
2023-01-16 Added XREF MetaCyc:RXN-19719
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.