While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
GO:0140981
JSON
medium-chain fatty acid omega-hydroxylase activity
Molecular Function
Definition (GO:0140981 GONUTS page)
Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
Comments
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0004497 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
MetaCyc | RXN-19719 | |
RHEA | 75279 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57618 | FMNH2(2-) |
has_participant | CHEBI | CHEBI:194241 | omega-hydroxy-medium-chain fatty acid anion |
has_participant | CHEBI | CHEBI:58210 | FMN(3-) |
has_participant | CHEBI | CHEBI:194240 | omega-methyl-medium-chain fatty acid anion |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0102114 | obsolete caprate dehydroxylase activity | replaced_by GO:0140981 |
GO:0102116 | obsolete laurate hydroxylase activity | replaced_by GO:0140981 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140981 based on ALL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
16-hydroxypalmitate dehydrogenase activity
|
38,987,756.00 | 100.00 | 5 | 5 |
medium-chain fatty acid omega-hydroxylase activity
|
38,987,756.00 | 100.00 | 5 | 5 |
lauric acid metabolic process
|
822,526.56 | 2.11 | 5 | 237 |
lipid hydroxylation
|
735,618.00 | 1.89 | 5 | 265 |
arachidonate omega-hydroxylase activity
|
628,834.80 | 1.57 | 2 | 124 |
icosanoid biosynthetic process
|
603,525.60 | 1.55 | 5 | 323 |
long-chain fatty acid omega-hydroxylase activity
|
604,461.40 | 1.52 | 2 | 129 |
omega-hydroxylase P450 pathway
|
553,017.90 | 1.39 | 2 | 141 |
arachidonate monooxygenase activity
|
439,051.30 | 1.13 | 5 | 444 |
alkane 1-monooxygenase activity
|
139,043.36 | 0.36 | 5 | 1,402 |
Totals | 113 | 89172855 |
No co-occurrence statistics for GO:0140981 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
16-hydroxypalmitate dehydrogenase activity
|
645,899.50 | 100.00 | 2 | 2 |
medium-chain fatty acid omega-hydroxylase activity
|
645,899.50 | 100.00 | 2 | 2 |
arachidonate omega-hydroxylase activity
|
143,533.22 | 22.22 | 2 | 9 |
lipid hydroxylation
|
80,737.44 | 12.50 | 2 | 16 |
lauric acid metabolic process
|
64,589.95 | 10.00 | 2 | 20 |
arachidonate monooxygenase activity
|
58,718.13 | 9.09 | 2 | 22 |
omega-hydroxylase P450 pathway
|
58,718.13 | 9.09 | 2 | 22 |
icosanoid biosynthetic process
|
46,135.68 | 7.14 | 2 | 28 |
alkane 1-monooxygenase activity
|
34,913.48 | 5.41 | 2 | 37 |
linoleic acid metabolic process
|
13,890.31 | 2.15 | 2 | 93 |
Totals | 29 | 43873 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. |
2023-06-13 | Added | XREF | RHEA:75279 |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
2023-01-16 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
2023-01-16 | Added | XREF | MetaCyc:RXN-19719 |
2023-01-16 | Added | TERM | medium-chain fatty acid omega-hydroxylase activity |
2023-01-16 | Added | RELATION | is a GO:0120250 (fatty acid omega-hydroxylase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-16 | Added | TERM | medium-chain fatty acid omega-hydroxylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
2023-01-16 | Added | DEFINITION | Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-16 | Added | RELATION | is a GO:0120250 (fatty acid omega-hydroxylase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | XREF | RHEA:75279 |
2023-01-16 | Added | XREF | MetaCyc:RXN-19719 |
Timestamp | Action | Category | Detail |
---|
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