This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0140981 JSON

medium-chain fatty acid omega-hydroxylase activity

Molecular Function

Definition (GO:0140981 GONUTS page)

Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

5 annotations

Ancestor Chart

Ancestor chart for GO:0140981
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
MetaCyc RXN-19719
RHEA 75279

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:194240 omega-methyl-medium-chain fatty acid anion
has_participant CHEBI CHEBI:58210 FMN(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57618 FMNH2(2-)
has_participant CHEBI CHEBI:194241 omega-hydroxy-medium-chain fatty acid anion
has_participant CHEBI CHEBI:15377 water

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0102114 obsolete caprate dehydroxylase activity replaced_by GO:0140981
GO:0102116 obsolete laurate hydroxylase activity replaced_by GO:0140981

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140981 based on ALL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0103002
16-hydroxypalmitate dehydrogenase activity
39,630,972.00 100.00 5 5
GO:0140981
medium-chain fatty acid omega-hydroxylase activity
39,630,972.00 100.00 5 5
GO:0048252
lauric acid metabolic process
783,220.80 1.98 5 253
GO:0002933
lipid hydroxylation
750,586.60 1.89 5 264
GO:0052869
arachidonate omega-hydroxylase activity
639,209.25 1.57 2 124
GO:0102033
long-chain fatty acid omega-hydroxylase activity
629,063.06 1.55 2 126
GO:0046456
icosanoid biosynthetic process
584,527.60 1.47 5 339
GO:0097267
omega-hydroxylase P450 pathway
570,229.80 1.41 2 139
GO:0008391
arachidonate monooxygenase activity
416,291.75 1.05 5 476
GO:0018685
alkane 1-monooxygenase activity
139,939.88 0.35 5 1,416
Totals 116 88947903
No co-occurrence statistics for GO:0140981 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0103002
16-hydroxypalmitate dehydrogenase activity
705,766.50 100.00 2 2
GO:0140981
medium-chain fatty acid omega-hydroxylase activity
705,766.50 100.00 2 2
GO:0052869
arachidonate omega-hydroxylase activity
156,837.00 22.22 2 9
GO:0002933
lipid hydroxylation
88,220.81 12.50 2 16
GO:0048252
lauric acid metabolic process
70,576.65 10.00 2 20
GO:0097267
omega-hydroxylase P450 pathway
70,576.65 10.00 2 20
GO:0008391
arachidonate monooxygenase activity
61,371.00 8.70 2 23
GO:0046456
icosanoid biosynthetic process
50,411.90 7.14 2 28
GO:0018685
alkane 1-monooxygenase activity
38,149.54 5.41 2 37
GO:0043651
linoleic acid metabolic process
14,551.89 2.06 2 97
Totals 29 48272

Change Log

Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-06-13 Added XREF RHEA:75279
2023-01-18 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added TERM medium-chain fatty acid omega-hydroxylase activity
2023-01-16 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added XREF MetaCyc:RXN-19719
2023-01-16 Added RELATION is a GO:0120250 (fatty acid omega-hydroxylase activity)
Timestamp Action Category Detail
2023-01-16 Added TERM medium-chain fatty acid omega-hydroxylase activity
Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-01-18 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2023-01-16 Added DEFINITION Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
Timestamp Action Category Detail
2023-01-16 Added RELATION is a GO:0120250 (fatty acid omega-hydroxylase activity)
Timestamp Action Category Detail
2023-06-13 Added XREF RHEA:75279
2023-01-16 Added XREF MetaCyc:RXN-19719
Timestamp Action Category Detail
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