This term is obsolete.

GO:0141152 JSON

glycerol-3-phosphate dehydrogenase (NAD+) activity

Molecular Function

Definition (GO:0141152 GONUTS page)

Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.

9,326 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-glycerophosphate dehydrogenase activity broad
glycerol 1-phosphate dehydrogenase activity broad
alpha-glycerophosphate dehydrogenase (NAD) activity exact
glycerol phosphate dehydrogenase (NAD) activity exact
NAD-dependent glycerol-3-phosphate dehydrogenase activity exact
NAD-L-glycerol-3-phosphate dehydrogenase activity exact
hydroglycerophosphate dehydrogenase activity broad
L-alpha-glycerol phosphate dehydrogenase activity broad
alpha-glycerol phosphate dehydrogenase (NAD) activity exact
L-alpha-glycerophosphate dehydrogenase activity broad

Ancestor Chart

Ancestor chart for GO:0141152
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.8
KEGG_REACTION R00842
MetaCyc 1.1.1.8-RXN
RHEA 11092

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57597 sn-glycerol 3-phosphate(2-)
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:57642 glycerone phosphate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0141152 based on ALL annotations
The top 100 of 273 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0141152
glycerol-3-phosphate dehydrogenase (NAD+) activity
21,274.95 100.00 9,314 9,314
GO:0006116
obsolete NADH oxidation
4,221.51 19.73 9,054 45,629
GO:0046168
glycerol-3-phosphate catabolic process
2,169.78 10.18 9,160 89,815
GO:0006072
glycerol-3-phosphate metabolic process
1,286.20 6.01 8,395 138,861
GO:0042803
protein homodimerization activity
609.13 2.82 5,932 207,186
GO:0006650
glycerophospholipid metabolic process
426.38 1.71 979 48,849
GO:0006127
glycerol-3-phosphate shuttle
9,528.55 1.23 116 259
GO:0060373
regulation of ventricular cardiac muscle cell membrane depolarization
3,812.27 0.95 93 519
GO:0045821
positive regulation of glycolytic process
1,308.82 0.91 98 1,593
GO:0010765
positive regulation of sodium ion transport
1,416.30 0.88 93 1,397
Totals 94327 72279438
No co-occurrence statistics for GO:0141152 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0141152
glycerol-3-phosphate dehydrogenase (NAD+) activity
156,837.00 100.00 9 9
GO:0006973
intracellular accumulation of glycerol
44,810.57 14.29 2 7
GO:0006067
ethanol metabolic process
13,069.75 5.00 1 12
GO:0007629
flight behavior
6,273.48 3.03 1 25
GO:0006072
glycerol-3-phosphate metabolic process
2,402.32 1.53 7 457
GO:0006116
obsolete NADH oxidation
2,166.26 1.37 5 362
GO:0055093
response to hyperoxia
2,119.42 1.22 1 74
GO:0006972
hyperosmotic response
1,972.79 1.20 2 159
GO:0006114
glycerol biosynthetic process
1,522.69 0.90 1 103
GO:0006127
glycerol-3-phosphate shuttle
1,188.16 0.71 1 132
Totals 47 547754

Change Log

Timestamp Action Category Detail
2024-03-22 Added RELATION has part GO:0061610 (glycerol to glycerone phosphate metabolic process)
2024-02-24 Added SYNONYM NAD-L-glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM hydroglycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NADH-dihydroxyacetone phosphate reductase activity
2024-02-24 Added SYNONYM glycerol 1-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-dependent glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM glycerophosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM glycerol-3-phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM L-glycerol phosphate dehydrogenase activity
Timestamp Action Category Detail
2024-02-24 Added TERM glycerol-3-phosphate dehydrogenase (NAD+) activity
Timestamp Action Category Detail
2024-02-24 Added SYNONYM NAD-L-glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM hydroglycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NADH-dihydroxyacetone phosphate reductase activity
2024-02-24 Added SYNONYM glycerol 1-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-dependent glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM glycerophosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM glycerol-3-phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM L-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-linked glycerol 3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-alpha-glycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM glycerol-3-phosphate dehydrogenase [NAD+] activity
2024-02-24 Added SYNONYM alpha-glycerol phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM L-glycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerophosphate dehydrogenase activity
2024-02-24 Added DEFINITION Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
2024-02-24 Added SYNONYM alpha-glycerophosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM glycerol phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM NAD-dependent glycerol-3-phosphate dehydrogenase activity
Timestamp Action Category Detail
2024-03-22 Added RELATION has part GO:0061610 (glycerol to glycerone phosphate metabolic process)
2024-02-24 Added RELATION has part GO:0006127 (glycerol-3-phosphate shuttle)
2024-02-24 Added RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2024-02-24 Added XREF EC:1.1.1.8
2024-02-24 Added XREF MetaCyc:1.1.1.8-RXN
2024-02-24 Added XREF RHEA:11092
2024-02-24 Added XREF KEGG_REACTION:R00842
Timestamp Action Category Detail
2024-02-24 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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