GO:0141152
JSON
glycerol-3-phosphate dehydrogenase (NAD+) activity
Molecular Function
Definition (GO:0141152 GONUTS page)
Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
NAD-dependent glycerol phosphate dehydrogenase activity | exact |
glycerophosphate dehydrogenase (NAD) activity | exact |
glycerol-3-phosphate dehydrogenase (NAD) activity | exact |
L-glycerol phosphate dehydrogenase activity | broad |
NAD-linked glycerol 3-phosphate dehydrogenase activity | exact |
NAD-alpha-glycerophosphate dehydrogenase activity | exact |
L-alpha-glycerophosphate dehydrogenase activity | broad |
alpha-glycerophosphate dehydrogenase (NAD) activity | exact |
glycerol phosphate dehydrogenase (NAD) activity | exact |
NAD-dependent glycerol-3-phosphate dehydrogenase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0141152 | glycerol-3-phosphate dehydrogenase (NAD+) activity | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.8 | |
KEGG_REACTION | R00842 | |
MetaCyc | 1.1.1.8-RXN | |
RHEA | 11092 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57642 | glycerone phosphate(2-) |
has_participant | CHEBI | CHEBI:57597 | sn-glycerol 3-phosphate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0141152 based on ALL annotations
The top 100 of 262 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glycerol-3-phosphate dehydrogenase (NAD+) activity
|
21,785.74 | 100.00 | 8,948 | 8,948 |
NADH oxidation
|
4,290.20 | 19.58 | 8,689 | 44,123 |
glycerol-3-phosphate catabolic process
|
2,175.48 | 9.97 | 8,794 | 88,065 |
glycerol-3-phosphate metabolic process
|
1,288.66 | 5.88 | 8,038 | 135,888 |
protein homodimerization activity
|
609.20 | 2.75 | 5,728 | 204,841 |
glycerophospholipid metabolic process
|
441.84 | 1.74 | 979 | 48,271 |
glycerophosphate shuttle
|
17,796.80 | 1.29 | 116 | 142 |
regulation of ventricular cardiac muscle cell membrane depolarization
|
3,911.34 | 0.99 | 93 | 518 |
positive regulation of glycolytic process
|
1,339.40 | 0.94 | 98 | 1,594 |
positive regulation of sodium ion transport
|
1,458.66 | 0.91 | 93 | 1,389 |
Totals | 90739 | 70612660 |
No co-occurrence statistics for GO:0141152 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glycerol-3-phosphate dehydrogenase (NAD+) activity
|
143,533.22 | 100.00 | 9 | 9 |
intracellular accumulation of glycerol
|
41,009.49 | 14.29 | 2 | 7 |
glycerophosphate shuttle
|
15,948.14 | 5.88 | 1 | 9 |
ethanol metabolic process
|
11,961.10 | 5.00 | 1 | 12 |
flight behavior
|
5,741.33 | 3.03 | 1 | 25 |
glycerol-3-phosphate metabolic process
|
3,294.21 | 2.28 | 7 | 305 |
NADH oxidation
|
2,256.81 | 1.55 | 5 | 318 |
hyperosmotic response
|
1,840.17 | 1.23 | 2 | 156 |
response to hyperoxia
|
1,939.64 | 1.22 | 1 | 74 |
glycerol biosynthetic process
|
1,577.29 | 1.01 | 1 | 91 |
Totals | 47 | 507486 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | RELATION | has part GO:0061610 (glycerol to glycerone phosphate metabolic process) |
2024-02-24 | Added | SYNONYM | glycerol phosphate dehydrogenase (NAD) activity |
2024-02-24 | Added | SYNONYM | NAD-dependent glycerol-3-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-L-glycerol-3-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | hydroglycerophosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | L-alpha-glycerol phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NADH-dihydroxyacetone phosphate reductase activity |
2024-02-24 | Added | SYNONYM | glycerol 1-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-dependent glycerol phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | glycerophosphate dehydrogenase (NAD) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | TERM | glycerol-3-phosphate dehydrogenase (NAD+) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | SYNONYM | glycerol phosphate dehydrogenase (NAD) activity |
2024-02-24 | Added | SYNONYM | NAD-dependent glycerol-3-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-L-glycerol-3-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | hydroglycerophosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | L-alpha-glycerol phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NADH-dihydroxyacetone phosphate reductase activity |
2024-02-24 | Added | SYNONYM | glycerol 1-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-dependent glycerol phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | glycerophosphate dehydrogenase (NAD) activity |
2024-02-24 | Added | SYNONYM | glycerol-3-phosphate dehydrogenase [NAD+] activity |
2024-02-24 | Added | DEFINITION | Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH. |
2024-02-24 | Added | SYNONYM | glycerol-3-phosphate dehydrogenase (NAD) activity |
2024-02-24 | Added | SYNONYM | L-glycerol phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-linked glycerol 3-phosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | NAD-alpha-glycerophosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | alpha-glycerol phosphate dehydrogenase (NAD) activity |
2024-02-24 | Added | SYNONYM | L-glycerophosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | L-alpha-glycerophosphate dehydrogenase activity |
2024-02-24 | Added | SYNONYM | alpha-glycerophosphate dehydrogenase (NAD) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | RELATION | has part GO:0061610 (glycerol to glycerone phosphate metabolic process) |
2024-02-24 | Added | RELATION | has part GO:0006127 (glycerophosphate shuttle) |
2024-02-24 | Added | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | XREF | EC:1.1.1.8 |
2024-02-24 | Added | XREF | MetaCyc:1.1.1.8-RXN |
2024-02-24 | Added | XREF | RHEA:11092 |
2024-02-24 | Added | XREF | KEGG_REACTION:R00842 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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