This term is obsolete.

GO:0141152 JSON

glycerol-3-phosphate dehydrogenase (NAD+) activity

Molecular Function

Definition (GO:0141152 GONUTS page)

Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.

8,960 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
NAD-dependent glycerol phosphate dehydrogenase activity exact
glycerophosphate dehydrogenase (NAD) activity exact
glycerol-3-phosphate dehydrogenase (NAD) activity exact
L-glycerol phosphate dehydrogenase activity broad
NAD-linked glycerol 3-phosphate dehydrogenase activity exact
NAD-alpha-glycerophosphate dehydrogenase activity exact
L-alpha-glycerophosphate dehydrogenase activity broad
alpha-glycerophosphate dehydrogenase (NAD) activity exact
glycerol phosphate dehydrogenase (NAD) activity exact
NAD-dependent glycerol-3-phosphate dehydrogenase activity exact

Ancestor Chart

Ancestor chart for GO:0141152
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.8
KEGG_REACTION R00842
MetaCyc 1.1.1.8-RXN
RHEA 11092

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57642 glycerone phosphate(2-)
has_participant CHEBI CHEBI:57597 sn-glycerol 3-phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:57945 NADH(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0141152 based on ALL annotations
The top 100 of 262 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glycerol-3-phosphate dehydrogenase (NAD+) activity
21,785.74 100.00 8,948 8,948
NADH oxidation
4,290.20 19.58 8,689 44,123
glycerol-3-phosphate catabolic process
2,175.48 9.97 8,794 88,065
glycerol-3-phosphate metabolic process
1,288.66 5.88 8,038 135,888
protein homodimerization activity
609.20 2.75 5,728 204,841
glycerophospholipid metabolic process
441.84 1.74 979 48,271
glycerophosphate shuttle
17,796.80 1.29 116 142
regulation of ventricular cardiac muscle cell membrane depolarization
3,911.34 0.99 93 518
positive regulation of glycolytic process
1,339.40 0.94 98 1,594
positive regulation of sodium ion transport
1,458.66 0.91 93 1,389
Totals 90739 70612660
No co-occurrence statistics for GO:0141152 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glycerol-3-phosphate dehydrogenase (NAD+) activity
143,533.22 100.00 9 9
intracellular accumulation of glycerol
41,009.49 14.29 2 7
glycerophosphate shuttle
15,948.14 5.88 1 9
ethanol metabolic process
11,961.10 5.00 1 12
flight behavior
5,741.33 3.03 1 25
glycerol-3-phosphate metabolic process
3,294.21 2.28 7 305
NADH oxidation
2,256.81 1.55 5 318
hyperosmotic response
1,840.17 1.23 2 156
response to hyperoxia
1,939.64 1.22 1 74
glycerol biosynthetic process
1,577.29 1.01 1 91
Totals 47 507486

Change Log

Timestamp Action Category Detail
2024-03-22 Added RELATION has part GO:0061610 (glycerol to glycerone phosphate metabolic process)
2024-02-24 Added SYNONYM glycerol phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM NAD-dependent glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-L-glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM hydroglycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NADH-dihydroxyacetone phosphate reductase activity
2024-02-24 Added SYNONYM glycerol 1-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-dependent glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM glycerophosphate dehydrogenase (NAD) activity
Timestamp Action Category Detail
2024-02-24 Added TERM glycerol-3-phosphate dehydrogenase (NAD+) activity
Timestamp Action Category Detail
2024-02-24 Added SYNONYM glycerol phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM NAD-dependent glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-L-glycerol-3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM hydroglycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NADH-dihydroxyacetone phosphate reductase activity
2024-02-24 Added SYNONYM glycerol 1-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-dependent glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM glycerophosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM glycerol-3-phosphate dehydrogenase [NAD+] activity
2024-02-24 Added DEFINITION Catalysis of the reaction: NAD+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADH.
2024-02-24 Added SYNONYM glycerol-3-phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM L-glycerol phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-linked glycerol 3-phosphate dehydrogenase activity
2024-02-24 Added SYNONYM NAD-alpha-glycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM alpha-glycerol phosphate dehydrogenase (NAD) activity
2024-02-24 Added SYNONYM L-glycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM L-alpha-glycerophosphate dehydrogenase activity
2024-02-24 Added SYNONYM alpha-glycerophosphate dehydrogenase (NAD) activity
Timestamp Action Category Detail
2024-03-22 Added RELATION has part GO:0061610 (glycerol to glycerone phosphate metabolic process)
2024-02-24 Added RELATION has part GO:0006127 (glycerophosphate shuttle)
2024-02-24 Added RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2024-02-24 Added XREF EC:1.1.1.8
2024-02-24 Added XREF MetaCyc:1.1.1.8-RXN
2024-02-24 Added XREF RHEA:11092
2024-02-24 Added XREF KEGG_REACTION:R00842
Timestamp Action Category Detail
2024-02-24 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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