GO:0141208
JSON
NAD-dependent protein lysine delactylase activity
Molecular Function
Definition (GO:0141208 GONUTS page)
Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD. PMID:38512451
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| protein lysine delactylase activity | broad |
Ancestor Chart
Ancestor chart for GO:0141208
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A0A0G2K6D8 | 10116 | A0A0G2K6D8_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6J1T8 | 10116 | A6J1T8_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | B2RZ30 | 10116 | B2RZ30_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | G3V641 | 10116 | G3V641_RAT | GO:0034979 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
| NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
| NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
| NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
| Database | ID | Description |
|---|---|---|
| RHEA | 80287 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_participant | CHEBI | CHEBI:231527 | N(6)-[(S)-lactoyl]-L-lysine residue |
| has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
| has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
| has_participant | CHEBI | CHEBI:231484 | 2''-O-(S)-lactoyl-ADP-D-ribose(2-) |
| has_participant | CHEBI | CHEBI:17154 | nicotinamide |
| has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0141208 based on ALL annotations
The top 100 of 230 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
NAD-dependent protein lysine delactylase activity
|
1,179,493.20 | 100.00 | 168 | 168 |
|
maintenance of nucleus location
|
1,179,493.20 | 44.05 | 74 | 74 |
|
histone H3K deacetylase activity
|
1,179,493.20 | 44.05 | 74 | 74 |
|
negative regulation of cellular response to testosterone stimulus
|
1,179,493.20 | 44.05 | 74 | 74 |
|
NAD-dependent histone decrotonylase activity
|
1,163,766.60 | 43.79 | 74 | 75 |
|
positive regulation of macrophage apoptotic process
|
1,041,630.40 | 38.42 | 68 | 77 |
|
regulation of smooth muscle cell apoptotic process
|
978,116.30 | 37.36 | 68 | 82 |
|
regulation of peroxisome proliferator activated receptor signaling pathway
|
771,207.06 | 33.33 | 68 | 104 |
|
NAD-dependent protein-lysine depropionylase activity
|
531,162.50 | 27.09 | 68 | 151 |
|
negative regulation of prostaglandin biosynthetic process
|
466,311.28 | 25.00 | 68 | 172 |
| Totals | 5882 | 316547 | ||
No co-occurrence statistics for GO:0141208 based on MANUAL annotations
The top 100 of 209 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
NAD-dependent protein lysine delactylase activity
|
128,321.19 | 100.00 | 11 | 11 |
|
positive regulation of mitochondrial transcription
|
52,838.13 | 33.33 | 7 | 17 |
|
NAD-dependent protein lysine deacetylase activity
|
32,826.35 | 25.58 | 11 | 43 |
|
NAD-dependent histone decrotonylase activity
|
96,240.89 | 25.00 | 3 | 4 |
|
positive regulation of oxidative phosphorylation
|
35,929.93 | 24.14 | 7 | 25 |
|
NAD-dependent protein-lysine depropionylase activity
|
54,994.79 | 20.00 | 3 | 7 |
|
protein depropionylation
|
54,994.79 | 20.00 | 3 | 7 |
|
maintenance of nucleus location
|
128,321.19 | 18.18 | 2 | 2 |
|
histone H3K deacetylase activity
|
128,321.19 | 18.18 | 2 | 2 |
|
negative regulation of cellular response to testosterone stimulus
|
128,321.19 | 18.18 | 2 | 2 |
| Totals | 274 | 6769 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-11-14 | Added | XREF | RHEA:80287 |
| 2024-09-21 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein. |
| 2024-09-21 | Added | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD. |
| 2024-09-20 | Added | SYNONYM | protein lysine delactylase activity |
| 2024-09-20 | Added | RELATION | is a GO:0034979 (NAD-dependent protein lysine deacetylase activity) |
| 2024-09-20 | Deleted | RELATION | is a GO:0160215 (deacylase activity) |
| 2024-09-18 | Updated | TERM | NAD-dependent protein lysine delactylase activity |
| 2024-09-18 | Deleted | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
| 2024-09-18 | Added | RELATION | is a GO:0160215 (deacylase activity) |
| 2024-06-08 | Added | TERM | protein lysine delactylase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-18 | Updated | TERM | NAD-dependent protein lysine delactylase activity |
| 2024-06-08 | Added | TERM | protein lysine delactylase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-21 | Deleted | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein. |
| 2024-09-21 | Added | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD. |
| 2024-09-20 | Added | SYNONYM | protein lysine delactylase activity |
| 2024-06-08 | Added | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-20 | Added | RELATION | is a GO:0034979 (NAD-dependent protein lysine deacetylase activity) |
| 2024-09-20 | Deleted | RELATION | is a GO:0160215 (deacylase activity) |
| 2024-09-18 | Deleted | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
| 2024-09-18 | Added | RELATION | is a GO:0160215 (deacylase activity) |
| 2024-06-08 | Added | RELATION | is a GO:0033558 (protein lysine deacetylase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-11-14 | Added | XREF | RHEA:80287 |
| Timestamp | Action | Category | Detail |
|---|
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