This term is obsolete.

GO:0141208 JSON

NAD-dependent protein lysine delactylase activity

Molecular Function

Definition (GO:0141208 GONUTS page)

Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD. PMID:38512451

171 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein lysine delactylase activity broad

Ancestor Chart

Ancestor chart for GO:0141208
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2K6D8 10116 A0A0G2K6D8_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J1T8 10116 A6J1T8_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B2RZ30 10116 B2RZ30_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein G3V641 10116 G3V641_RAT GO:0034979 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
RHEA 80287

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:231527 N(6)-[(S)-lactoyl]-L-lysine residue
has_participant CHEBI CHEBI:29969 L-lysinium residue
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:231484 2''-O-(S)-lactoyl-ADP-D-ribose(2-)
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0141208 based on ALL annotations
The top 100 of 230 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein lysine delactylase activity
1,179,493.20 100.00 168 168
maintenance of nucleus location
1,179,493.20 44.05 74 74
histone H3K deacetylase activity
1,179,493.20 44.05 74 74
negative regulation of cellular response to testosterone stimulus
1,179,493.20 44.05 74 74
NAD-dependent histone decrotonylase activity
1,163,766.60 43.79 74 75
positive regulation of macrophage apoptotic process
1,041,630.40 38.42 68 77
regulation of smooth muscle cell apoptotic process
978,116.30 37.36 68 82
regulation of peroxisome proliferator activated receptor signaling pathway
771,207.06 33.33 68 104
NAD-dependent protein-lysine depropionylase activity
531,162.50 27.09 68 151
negative regulation of prostaglandin biosynthetic process
466,311.28 25.00 68 172
Totals 5882 316547
No co-occurrence statistics for GO:0141208 based on MANUAL annotations
The top 100 of 209 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD-dependent protein lysine delactylase activity
128,321.19 100.00 11 11
positive regulation of mitochondrial transcription
52,838.13 33.33 7 17
NAD-dependent protein lysine deacetylase activity
32,826.35 25.58 11 43
NAD-dependent histone decrotonylase activity
96,240.89 25.00 3 4
positive regulation of oxidative phosphorylation
35,929.93 24.14 7 25
NAD-dependent protein-lysine depropionylase activity
54,994.79 20.00 3 7
protein depropionylation
54,994.79 20.00 3 7
maintenance of nucleus location
128,321.19 18.18 2 2
histone H3K deacetylase activity
128,321.19 18.18 2 2
negative regulation of cellular response to testosterone stimulus
128,321.19 18.18 2 2
Totals 274 6769

Change Log

Timestamp Action Category Detail
2024-11-14 Added XREF RHEA:80287
2024-09-21 Deleted DEFINITION Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein.
2024-09-21 Added DEFINITION Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD.
2024-09-20 Added SYNONYM protein lysine delactylase activity
2024-09-20 Added RELATION is a GO:0034979 (NAD-dependent protein lysine deacetylase activity)
2024-09-20 Deleted RELATION is a GO:0160215 (deacylase activity)
2024-09-18 Updated TERM NAD-dependent protein lysine delactylase activity
2024-09-18 Deleted RELATION is a GO:0033558 (protein lysine deacetylase activity)
2024-09-18 Added RELATION is a GO:0160215 (deacylase activity)
2024-06-08 Added TERM protein lysine delactylase activity
Timestamp Action Category Detail
2024-09-18 Updated TERM NAD-dependent protein lysine delactylase activity
2024-06-08 Added TERM protein lysine delactylase activity
Timestamp Action Category Detail
2024-09-21 Deleted DEFINITION Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein.
2024-09-21 Added DEFINITION Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, transfering a lactoyl group attached to a lysine residue in a protein to NAD.
2024-09-20 Added SYNONYM protein lysine delactylase activity
2024-06-08 Added DEFINITION Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein.
Timestamp Action Category Detail
2024-09-20 Added RELATION is a GO:0034979 (NAD-dependent protein lysine deacetylase activity)
2024-09-20 Deleted RELATION is a GO:0160215 (deacylase activity)
2024-09-18 Deleted RELATION is a GO:0033558 (protein lysine deacetylase activity)
2024-09-18 Added RELATION is a GO:0160215 (deacylase activity)
2024-06-08 Added RELATION is a GO:0033558 (protein lysine deacetylase activity)
Timestamp Action Category Detail
2024-11-14 Added XREF RHEA:80287
Timestamp Action Category Detail
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