GO:0160216
JSON
protein lysine delactylase activity
Molecular Function
Definition (GO:0160216 GONUTS page)
Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] = (S)-lactate + L-lysyl-[protein]. PMID:35044827
Ancestor Chart
Ancestor chart for GO:0160216
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
RHEA | 81387 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:231527 | N(6)-[(S)-lactoyl]-L-lysine residue |
has_participant | CHEBI | CHEBI:29969 | L-lysinium residue |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:16651 | (S)-lactate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0160216 based on ALL annotations
The top 100 of 190 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein lysine delactylase activity
|
676,296.44 | 100.00 | 293 | 293 |
histone decrotonylase activity
|
521,051.62 | 76.84 | 292 | 379 |
protein de-2-hydroxyisobutyrylase activity
|
676,296.44 | 68.26 | 200 | 200 |
fungiform papilla formation
|
349,419.84 | 24.47 | 93 | 180 |
Krueppel-associated box domain binding
|
355,538.72 | 24.47 | 92 | 175 |
protein decrotonylase activity
|
188,404.64 | 23.35 | 173 | 621 |
hair follicle placode formation
|
204,938.33 | 15.42 | 70 | 231 |
protein lysine deacetylase activity
|
81,344.36 | 12.03 | 293 | 2,436 |
negative regulation of cardiac muscle cell differentiation
|
93,594.60 | 10.67 | 93 | 672 |
negative regulation of transcription by competitive promoter binding
|
89,798.70 | 10.43 | 96 | 723 |
Totals | 10251 | 1137288 |
No co-occurrence statistics for GO:0160216 based on MANUAL annotations
The top 100 of 179 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein lysine delactylase activity
|
64,160.59 | 100.00 | 22 | 22 |
histone decrotonylase activity
|
44,912.41 | 67.74 | 21 | 30 |
protein de-2-hydroxyisobutyrylase activity
|
64,160.59 | 63.64 | 14 | 14 |
fungiform papilla formation
|
48,120.44 | 36.00 | 9 | 12 |
protein decrotonylase activity
|
64,160.59 | 31.82 | 7 | 7 |
Krueppel-associated box domain binding
|
44,912.41 | 28.00 | 7 | 10 |
hair follicle placode formation
|
27,497.40 | 26.47 | 9 | 21 |
protein lysine deacetylase activity
|
14,418.11 | 21.98 | 20 | 89 |
histone H4K16 deacetylase activity, hydrolytic mechanism
|
20,050.19 | 15.15 | 5 | 16 |
positive regulation of male mating behavior
|
28,515.82 | 14.81 | 4 | 9 |
Totals | 583 | 23512 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-11 | Added | XREF | RHEA:81387 |
2024-09-20 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2024-09-18 | Added | RELATION | is a GO:0160215 (deacylase activity) |
2024-09-18 | Added | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] = (S)-lactate + L-lysyl-[protein]. |
2024-09-18 | Added | TERM | protein lysine delactylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-18 | Added | TERM | protein lysine delactylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-18 | Added | DEFINITION | Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] = (S)-lactate + L-lysyl-[protein]. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-20 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2024-09-18 | Added | RELATION | is a GO:0160215 (deacylase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-11 | Added | XREF | RHEA:81387 |
Timestamp | Action | Category | Detail |
---|
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