Part of the pathway for thiamine biosynthesis.
GO:1990107
JSON
thiazole synthase activity
Molecular Function
Definition (GO:1990107 GONUTS page)
Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. PMID:22031445
Comments
Part of the pathway for thiamine biosynthesis.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:1990107
Child Term | Relationship to GO:1990107 |
---|---|
thiazole synthase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q46948 | 83333 | YAJL_ECOLI | GO:0009228 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:9592144 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.8.1.10 | |
RHEA | 26297 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:232372 | C-terminal N-glycylaminoethanethioate(1-) residue |
has_participant | CHEBI | CHEBI:62899 | (R,Z)- 2-carboxylato-4-methyl-5-[(2-phosphonatooxy)ethylidene]-2,5-dihydrothiazole(3-) |
has_participant | CHEBI | CHEBI:90778 | C-terminal Gly-Gly(1-) residue |
has_participant | CHEBI | CHEBI:77846 | dehydroglycine zwitterion |
has_participant | CHEBI | CHEBI:57792 | 1-deoxy-D-xylulose 5-phosphate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990107 based on ALL annotations
The top 50 of 50 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thiazole synthase activity
|
10,827.54 | 100.00 | 18,301 | 18,301 |
sulfurtransferase activity
|
1,056.64 | 9.66 | 16,601 | 170,113 |
thiamine diphosphate biosynthetic process
|
993.07 | 9.16 | 17,975 | 195,983 |
thiamine biosynthetic process
|
642.92 | 5.94 | 18,301 | 308,213 |
transferase activity
|
27.85 | 0.26 | 18,297 | 7,114,403 |
2-iminoacetate synthase complex
|
10,426.52 | 0.14 | 26 | 27 |
cytoplasm
|
6.96 | 0.06 | 16,402 | 25,503,657 |
plastid
|
2.92 | 0.03 | 103 | 381,567 |
flavin adenine dinucleotide binding
|
1.57 | 0.01 | 246 | 1,696,922 |
glycine oxidase activity
|
9.42 | 0.01 | 3 | 3,449 |
Totals | 106915 | 208166307 |
No co-occurrence statistics for GO:1990107 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Totals | 0 | 0 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Added | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. |
2024-09-19 | Deleted | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. |
2024-09-19 | Added | XREF | EC:2.8.1.10 |
2020-11-24 | Added | XREF | RHEA:26297 |
2013-05-30 | Added | RELATION | part of GO:0009228 (thiamine biosynthetic process) |
2013-05-30 | Added | RELATION | is a GO:0016783 (sulfurtransferase activity) |
2013-05-30 | Added | TERM | thiazole synthase activity |
2013-05-30 | Added | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. |
2013-05-30 | Added | SYNONYM | 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-05-30 | Added | TERM | thiazole synthase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Added | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. |
2024-09-19 | Deleted | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. |
2013-05-30 | Added | DEFINITION | Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. |
2013-05-30 | Added | SYNONYM | 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-05-30 | Added | RELATION | part of GO:0009228 (thiamine biosynthetic process) |
2013-05-30 | Added | RELATION | is a GO:0016783 (sulfurtransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Added | XREF | EC:2.8.1.10 |
2020-11-24 | Added | XREF | RHEA:26297 |
Timestamp | Action | Category | Detail |
---|
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