This term is obsolete.
Part of the pathway for thiamine biosynthesis.

GO:1990107 JSON

thiazole synthase activity

Molecular Function

Definition (GO:1990107 GONUTS page)

Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. PMID:22031445

Comments

Part of the pathway for thiamine biosynthesis.

18,301 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity exact

Ancestor Chart

Ancestor chart for GO:1990107
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:1990107

Child Term Relationship to
GO:1990107
thiazole synthase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q46948 83333 YAJL_ECOLI GO:0009228 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:9592144
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.8.1.10
RHEA 26297

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:232372 C-terminal N-glycylaminoethanethioate(1-) residue
has_participant CHEBI CHEBI:62899 (R,Z)- 2-carboxylato-4-methyl-5-[(2-phosphonatooxy)ethylidene]-2,5-dihydrothiazole(3-)
has_participant CHEBI CHEBI:90778 C-terminal Gly-Gly(1-) residue
has_participant CHEBI CHEBI:77846 dehydroglycine zwitterion
has_participant CHEBI CHEBI:57792 1-deoxy-D-xylulose 5-phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990107 based on ALL annotations
The top 50 of 50 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thiazole synthase activity
10,827.54 100.00 18,301 18,301
sulfurtransferase activity
1,056.64 9.66 16,601 170,113
thiamine diphosphate biosynthetic process
993.07 9.16 17,975 195,983
thiamine biosynthetic process
642.92 5.94 18,301 308,213
transferase activity
27.85 0.26 18,297 7,114,403
2-iminoacetate synthase complex
10,426.52 0.14 26 27
cytoplasm
6.96 0.06 16,402 25,503,657
plastid
2.92 0.03 103 381,567
flavin adenine dinucleotide binding
1.57 0.01 246 1,696,922
glycine oxidase activity
9.42 0.01 3 3,449
Totals 106915 208166307
No co-occurrence statistics for GO:1990107 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Totals 0 0

Change Log

Timestamp Action Category Detail
2024-09-19 Added DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O.
2024-09-19 Deleted DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.
2024-09-19 Added XREF EC:2.8.1.10
2020-11-24 Added XREF RHEA:26297
2013-05-30 Added RELATION part of GO:0009228 (thiamine biosynthetic process)
2013-05-30 Added RELATION is a GO:0016783 (sulfurtransferase activity)
2013-05-30 Added TERM thiazole synthase activity
2013-05-30 Added DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.
2013-05-30 Added SYNONYM 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity
Timestamp Action Category Detail
2013-05-30 Added TERM thiazole synthase activity
Timestamp Action Category Detail
2024-09-19 Added DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O.
2024-09-19 Deleted DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.
2013-05-30 Added DEFINITION Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.
2013-05-30 Added SYNONYM 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity
Timestamp Action Category Detail
2013-05-30 Added RELATION part of GO:0009228 (thiamine biosynthetic process)
2013-05-30 Added RELATION is a GO:0016783 (sulfurtransferase activity)
Timestamp Action Category Detail
2024-09-19 Added XREF EC:2.8.1.10
2020-11-24 Added XREF RHEA:26297
Timestamp Action Category Detail
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