The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
GO:1990130
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GATOR1 complex
Cellular Component
Definition (GO:1990130 GONUTS page)
A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. PMID:21900499 PMID:23723238 PMID:23974112 PMID:25934700 PMID:28199306 PMID:29199950
Comments
The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
IML1 complex | exact |
SEACIT complex | exact |
Ancestor Chart
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990130 based on ALL annotations
The top 100 of 314 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GATOR1 complex
|
14,694.62 | 100.00 | 13,266 | 13,266 |
positive regulation of autophagy
|
7,325.95 | 49.42 | 13,036 | 26,148 |
negative regulation of TORC1 signaling
|
6,818.42 | 46.19 | 13,137 | 28,312 |
TORC1 signaling
|
4,644.85 | 17.67 | 3,795 | 12,006 |
negative regulation of TOR signaling
|
2,428.63 | 11.90 | 3,955 | 23,930 |
cellular response to amino acid starvation
|
1,398.63 | 9.13 | 9,190 | 96,554 |
vacuolar membrane
|
675.54 | 4.39 | 6,611 | 143,805 |
lysosomal membrane
|
297.30 | 1.93 | 3,826 | 189,107 |
GTPase activator activity
|
283.34 | 1.91 | 9,269 | 480,710 |
meiotic cell cycle
|
250.56 | 1.52 | 1,625 | 95,303 |
Totals | 86715 | 5296828 |
No co-occurrence statistics for GO:1990130 based on MANUAL annotations
The top 93 of 93 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GATOR1 complex
|
7,339.77 | 100.00 | 176 | 176 |
negative regulation of TORC1 signaling
|
1,588.25 | 21.45 | 169 | 781 |
positive regulation of autophagy
|
1,556.34 | 20.82 | 162 | 764 |
cellular response to amino acid starvation
|
1,147.67 | 14.79 | 129 | 825 |
TORC1 signaling
|
951.79 | 9.90 | 52 | 401 |
vacuolar membrane
|
257.61 | 3.28 | 59 | 1,681 |
Seh1-associated complex
|
486.08 | 3.15 | 10 | 151 |
regulation of neuronal action potential
|
2,001.75 | 3.13 | 6 | 22 |
neuronal action potential propagation
|
1,100.97 | 2.86 | 6 | 40 |
regulation of TORC1 signaling
|
620.26 | 2.49 | 6 | 71 |
Totals | 1189 | 852526 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-08-22 | Deleted | DEFINITION | A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-22 | Added | DEFINITION | A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-14 | Added | DEFINITION | A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-14 | Deleted | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-04-22 | Added | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-04-22 | Deleted | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3. |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-03-22 | Updated | TERM | GATOR1 complex |
2017-03-22 | Deleted | SYNONYM | GATOR1 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-03-22 | Updated | TERM | GATOR1 complex |
2013-06-28 | Added | TERM | Iml1 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-08-22 | Deleted | DEFINITION | A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-22 | Added | DEFINITION | A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-14 | Added | DEFINITION | A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-08-14 | Deleted | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-04-22 | Added | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins. |
2021-04-22 | Deleted | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3. |
2017-03-22 | Deleted | SYNONYM | GATOR1 complex |
2017-03-22 | Added | SYNONYM | IML1 complex |
2015-05-11 | Deleted | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. |
2015-05-11 | Added | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3. |
2014-10-15 | Added | SYNONYM | SEACIT complex |
2014-10-15 | Added | SYNONYM | GATOR1 complex |
2013-06-28 | Added | DEFINITION | A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2016-12-22 | Added | RELATION | capable of part of GO:0016239 (positive regulation of macroautophagy) |
2014-10-15 | Added | RELATION | part of GO:0035859 (Seh1-associated complex) |
2013-06-28 | Added | RELATION | is a GO:0043234 (protein complex) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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