This term is obsolete.
The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.

GO:1990130 JSON

GATOR1 complex

Cellular Component

Definition (GO:1990130 GONUTS page)

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. PMID:21900499 PMID:23723238 PMID:23974112 PMID:25934700 PMID:28199306 PMID:29199950

Comments

The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.

13,362 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IML1 complex exact
SEACIT complex exact

Ancestor Chart

Ancestor chart for GO:1990130
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990130 based on ALL annotations
The top 100 of 314 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GATOR1 complex
14,694.62 100.00 13,266 13,266
positive regulation of autophagy
7,325.95 49.42 13,036 26,148
negative regulation of TORC1 signaling
6,818.42 46.19 13,137 28,312
TORC1 signaling
4,644.85 17.67 3,795 12,006
negative regulation of TOR signaling
2,428.63 11.90 3,955 23,930
cellular response to amino acid starvation
1,398.63 9.13 9,190 96,554
vacuolar membrane
675.54 4.39 6,611 143,805
lysosomal membrane
297.30 1.93 3,826 189,107
GTPase activator activity
283.34 1.91 9,269 480,710
meiotic cell cycle
250.56 1.52 1,625 95,303
Totals 86715 5296828
No co-occurrence statistics for GO:1990130 based on MANUAL annotations
The top 93 of 93 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GATOR1 complex
7,339.77 100.00 176 176
negative regulation of TORC1 signaling
1,588.25 21.45 169 781
positive regulation of autophagy
1,556.34 20.82 162 764
cellular response to amino acid starvation
1,147.67 14.79 129 825
TORC1 signaling
951.79 9.90 52 401
vacuolar membrane
257.61 3.28 59 1,681
Seh1-associated complex
486.08 3.15 10 151
regulation of neuronal action potential
2,001.75 3.13 6 22
neuronal action potential propagation
1,100.97 2.86 6 40
regulation of TORC1 signaling
620.26 2.49 6 71
Totals 1189 852526

Change Log

Timestamp Action Category Detail
2021-08-22 Deleted DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-22 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-03-22 Updated TERM GATOR1 complex
2017-03-22 Deleted SYNONYM GATOR1 complex
Timestamp Action Category Detail
2017-03-22 Updated TERM GATOR1 complex
2013-06-28 Added TERM Iml1 complex
Timestamp Action Category Detail
2021-08-22 Deleted DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-22 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2017-03-22 Deleted SYNONYM GATOR1 complex
2017-03-22 Added SYNONYM IML1 complex
2015-05-11 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins.
2015-05-11 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2014-10-15 Added SYNONYM SEACIT complex
2014-10-15 Added SYNONYM GATOR1 complex
2013-06-28 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins.
Timestamp Action Category Detail
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2016-12-22 Added RELATION capable of part of GO:0016239 (positive regulation of macroautophagy)
2014-10-15 Added RELATION part of GO:0035859 (Seh1-associated complex)
2013-06-28 Added RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
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