This term is obsolete.
The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.

GO:1990130 JSON

GATOR1 complex

Cellular Component

Definition (GO:1990130 GONUTS page)

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. PMID:21900499 PMID:23723238 PMID:23974112 PMID:25934700 PMID:28199306 PMID:29199950

Comments

The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.

13,724 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IML1 complex exact
SEACIT complex exact

Ancestor Chart

Ancestor chart for GO:1990130
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990130 based on ALL annotations
The top 100 of 303 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GATOR1 complex
14,546.68 100.00 13,622 13,622
positive regulation of autophagy
7,326.95 49.94 13,393 26,590
negative regulation of TORC1 signaling
6,736.48 46.10 13,489 29,128
TORC1 signaling
4,534.65 17.33 3,824 12,267
negative regulation of TOR signaling
2,396.93 11.84 4,036 24,494
cellular response to amino acid starvation
1,414.06 9.32 9,481 97,533
vacuolar membrane
640.40 4.22 6,866 155,960
lysosomal membrane
298.09 1.95 3,975 193,979
GTPase activator activity
281.46 1.92 9,544 493,255
meiotic cell cycle
250.75 1.53 1,636 94,910
Totals 89185 5307101
No co-occurrence statistics for GO:1990130 based on MANUAL annotations
The top 86 of 86 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GATOR1 complex
7,885.66 100.00 179 179
positive regulation of autophagy
1,683.23 20.97 165 773
negative regulation of TORC1 signaling
1,590.07 20.00 172 853
cellular response to amino acid starvation
1,225.41 14.70 131 843
vacuolar membrane
275.44 3.28 62 1,775
Seh1-associated complex
480.83 3.00 10 164
regulation of TORC1 signaling
666.39 2.46 6 71
GATOR2 complex
411.43 2.08 6 115
protein localization to lysosome
333.20 1.90 6 142
aorta morphogenesis
428.57 1.88 5 92
Totals 1124 893019

Change Log

Timestamp Action Category Detail
2021-08-22 Deleted DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-22 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2021-04-22 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2017-03-22 Updated TERM GATOR1 complex
2017-03-22 Added SYNONYM IML1 complex
Timestamp Action Category Detail
2017-03-22 Updated TERM GATOR1 complex
2013-06-28 Added TERM Iml1 complex
Timestamp Action Category Detail
2021-08-22 Deleted DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-22 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Added DEFINITION A GTPase-activating protein (GAP) complex that regulates mTOR signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.
2021-08-14 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2021-04-22 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2021-04-22 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In humans, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3). In S. cerevisiae, this complex is referred to as SEACIT AND contains the Iml1p, Npr2p, and Npr3p proteins.
2017-03-22 Added SYNONYM IML1 complex
2017-03-22 Deleted SYNONYM GATOR1 complex
2015-05-11 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.
2015-05-11 Deleted DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins.
2014-10-15 Added SYNONYM GATOR1 complex
2014-10-15 Added SYNONYM SEACIT complex
2013-06-28 Added DEFINITION A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins.
Timestamp Action Category Detail
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2016-12-22 Added RELATION capable of part of GO:0016239 (positive regulation of macroautophagy)
2014-10-15 Added RELATION part of GO:0035859 (Seh1-associated complex)
2013-06-28 Added RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
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