GO:1990147
JSON
talin binding
Molecular Function
Definition (GO:1990147 GONUTS page)
Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. PMID:23372168
Ancestor Chart
Ancestor chart for GO:1990147
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
| NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
| NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990147 based on ALL annotations
The top 20 of 20 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
talin binding
|
2,064,113.10 | 100.00 | 96 | 96 |
|
negative regulation of establishment of protein localization
|
2,021,988.40 | 97.96 | 96 | 98 |
|
positive regulation of establishment of protein localization
|
328,070.97 | 15.89 | 96 | 604 |
|
negative regulation of cell-substrate adhesion
|
194,842.53 | 9.44 | 96 | 1,017 |
|
regulation of cellular response to stress
|
179,813.86 | 8.71 | 96 | 1,102 |
|
regulation of glomerular filtration
|
110,751.35 | 5.35 | 91 | 1,696 |
|
vinculin binding
|
107,459.26 | 5.21 | 96 | 1,844 |
|
focal adhesion assembly
|
102,979.34 | 4.98 | 91 | 1,824 |
|
negative regulation of stress fiber assembly
|
31,750.22 | 1.54 | 91 | 5,916 |
|
regulation of actin cytoskeleton organization
|
7,677.15 | 0.37 | 96 | 25,811 |
| Totals | 1139 | 80575757 | ||
No co-occurrence statistics for GO:1990147 based on MANUAL annotations
The top 18 of 18 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
talin binding
|
282,306.60 | 100.00 | 5 | 5 |
|
negative regulation of establishment of protein localization
|
235,255.50 | 83.33 | 5 | 6 |
|
positive regulation of establishment of protein localization
|
34,427.63 | 12.20 | 5 | 41 |
|
regulation of cellular response to stress
|
31,367.40 | 11.11 | 5 | 45 |
|
regulation of glomerular filtration
|
24,548.40 | 8.51 | 4 | 46 |
|
negative regulation of cell-substrate adhesion
|
18,096.58 | 6.41 | 5 | 78 |
|
focal adhesion assembly
|
8,182.80 | 2.88 | 4 | 138 |
|
vinculin binding
|
7,508.15 | 2.66 | 5 | 188 |
|
negative regulation of stress fiber assembly
|
5,377.27 | 1.90 | 4 | 210 |
|
regulation of actin cytoskeleton organization
|
694.31 | 0.25 | 5 | 2,033 |
| Totals | 62 | 135121 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Added | DEFINITION | Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| 2013-07-28 | Added | DEFINITION | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| 2013-07-28 | Added | TERM | talin binding |
| 2013-07-28 | Added | RELATION | is a GO:0008092 (cytoskeletal protein binding) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2013-07-28 | Added | TERM | talin binding |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Added | DEFINITION | Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| 2013-07-28 | Added | DEFINITION | Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2013-07-28 | Added | RELATION | is a GO:0008092 (cytoskeletal protein binding) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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