This term is obsolete.
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).

GO:1990303 JSON

UBR1-RAD6 ubiquitin ligase complex

Cellular Component

Definition (GO:1990303 GONUTS page)

A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. PMID:19531475

Comments

This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).

247 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
UBR1-RAD6 complex exact

Ancestor Chart

Ancestor chart for GO:1990303
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990303 based on ALL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term PR S% #Together #Compared
UBR1-RAD6 ubiquitin ligase complex
812,244.94 100.00 240 240
regulation of dipeptide transport
812,244.94 100.00 240 240
RAD6-UBR2 ubiquitin ligase complex
765,060.56 89.37 227 241
stress-induced homeostatically regulated protein degradation pathway
660,809.44 81.36 240 295
error-free postreplication DNA repair
526,798.90 62.53 227 350
negative regulation of SREBP signaling pathway
435,131.22 51.72 225 420
sno(s)RNA transcription
240,704.44 29.14 227 766
cytoplasm protein quality control by the ubiquitin-proteasome system
180,165.23 22.18 240 1,082
mitotic G1 DNA damage checkpoint signaling
119,804.81 14.63 227 1,539
MUB1-RAD6-UBR2 ubiquitin ligase complex
90,872.16 11.12 227 2,029
Totals 9622 158363696
No co-occurrence statistics for GO:1990303 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term PR S% #Together #Compared
UBR1-RAD6 ubiquitin ligase complex
645,899.50 100.00 2 2
regulation of dipeptide transport
645,899.50 100.00 2 2
stress-induced homeostatically regulated protein degradation pathway
258,359.80 40.00 2 5
RAD6-UBR2 ubiquitin ligase complex
322,949.75 33.33 1 2
proteasome regulatory particle binding
80,737.44 11.11 1 8
sno(s)RNA transcription
71,766.61 10.00 1 9
cytoplasm protein quality control by the ubiquitin-proteasome system
44,544.79 6.90 2 29
mitochondria-associated ubiquitin-dependent protein catabolic process
46,135.68 6.67 1 14
MUB1-RAD6-UBR2 ubiquitin ligase complex
37,994.09 5.56 1 17
error-free postreplication DNA repair
30,757.12 4.55 1 21
Totals 56 525348

Change Log

Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-9103673
2020-11-03 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2020-11-03 Added RELATION is a GO:0140535 (intracellular protein-containing complex)
2019-08-30 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2019-08-30 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-08 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2017-10-07 Added XREF IntAct:EBI-9103673
2017-05-22 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2017-04-06 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
Timestamp Action Category Detail
2014-03-12 Added TERM UBR1-RAD6 ubiquitin ligase complex
Timestamp Action Category Detail
2014-04-21 Added DEFINITION A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
2014-04-21 Deleted DEFINITION A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing unacetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
2014-03-12 Added SYNONYM UBR1-RAD6 complex
2014-03-12 Added DEFINITION A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing unacetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
Timestamp Action Category Detail
2020-11-03 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2020-11-03 Added RELATION is a GO:0140535 (intracellular protein-containing complex)
2019-08-30 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2019-08-30 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-08 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2017-05-22 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2017-04-06 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2016-10-05 Added RELATION is a GO:0043234 (protein complex)
2016-06-22 Added RELATION is a GO:0044424 (obsolete intracellular part)
2016-06-22 Added RELATION is a GO:1990234 (transferase complex)
2016-06-22 Deleted RELATION is a GO:0000151 (ubiquitin ligase complex)
2015-06-25 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-06-18 Added RELATION capable of GO:0004842 (ubiquitin-protein transferase activity)
2014-06-05 Added RELATION is a GO:0043234 (protein complex)
2014-06-05 Added RELATION is a GO:0044424 (obsolete intracellular part)
2014-03-12 Added RELATION is a GO:0000151 (ubiquitin ligase complex)
2014-03-12 Added RELATION part of GO:0005622 (intracellular anatomical structure)
Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-9103673
2017-10-07 Added XREF IntAct:EBI-9103673
Timestamp Action Category Detail
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