This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
GO:1990303
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UBR1-RAD6 ubiquitin ligase complex
Cellular Component
Definition (GO:1990303 GONUTS page)
A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. PMID:19531475
Comments
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
UBR1-RAD6 complex | exact |
Ancestor Chart
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990303 based on ALL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
UBR1-RAD6 ubiquitin ligase complex
|
812,244.94 | 100.00 | 240 | 240 |
regulation of dipeptide transport
|
812,244.94 | 100.00 | 240 | 240 |
RAD6-UBR2 ubiquitin ligase complex
|
765,060.56 | 89.37 | 227 | 241 |
stress-induced homeostatically regulated protein degradation pathway
|
660,809.44 | 81.36 | 240 | 295 |
error-free postreplication DNA repair
|
526,798.90 | 62.53 | 227 | 350 |
negative regulation of SREBP signaling pathway
|
435,131.22 | 51.72 | 225 | 420 |
sno(s)RNA transcription
|
240,704.44 | 29.14 | 227 | 766 |
cytoplasm protein quality control by the ubiquitin-proteasome system
|
180,165.23 | 22.18 | 240 | 1,082 |
mitotic G1 DNA damage checkpoint signaling
|
119,804.81 | 14.63 | 227 | 1,539 |
MUB1-RAD6-UBR2 ubiquitin ligase complex
|
90,872.16 | 11.12 | 227 | 2,029 |
Totals | 9622 | 158363696 |
No co-occurrence statistics for GO:1990303 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
UBR1-RAD6 ubiquitin ligase complex
|
645,899.50 | 100.00 | 2 | 2 |
regulation of dipeptide transport
|
645,899.50 | 100.00 | 2 | 2 |
stress-induced homeostatically regulated protein degradation pathway
|
258,359.80 | 40.00 | 2 | 5 |
RAD6-UBR2 ubiquitin ligase complex
|
322,949.75 | 33.33 | 1 | 2 |
proteasome regulatory particle binding
|
80,737.44 | 11.11 | 1 | 8 |
sno(s)RNA transcription
|
71,766.61 | 10.00 | 1 | 9 |
cytoplasm protein quality control by the ubiquitin-proteasome system
|
44,544.79 | 6.90 | 2 | 29 |
mitochondria-associated ubiquitin-dependent protein catabolic process
|
46,135.68 | 6.67 | 1 | 14 |
MUB1-RAD6-UBR2 ubiquitin ligase complex
|
37,994.09 | 5.56 | 1 | 17 |
error-free postreplication DNA repair
|
30,757.12 | 4.55 | 1 | 21 |
Totals | 56 | 525348 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | IntAct:EBI-9103673 |
2020-11-03 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2020-11-03 | Added | RELATION | is a GO:0140535 (intracellular protein-containing complex) |
2019-08-30 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2019-08-30 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-08 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-10-07 | Added | XREF | IntAct:EBI-9103673 |
2017-05-22 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-04-06 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-03-12 | Added | TERM | UBR1-RAD6 ubiquitin ligase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-04-21 | Added | DEFINITION | A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. |
2014-04-21 | Deleted | DEFINITION | A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing unacetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. |
2014-03-12 | Added | SYNONYM | UBR1-RAD6 complex |
2014-03-12 | Added | DEFINITION | A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing unacetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2020-11-03 | Added | RELATION | is a GO:0140535 (intracellular protein-containing complex) |
2019-08-30 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2019-08-30 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-08 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-05-22 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-04-06 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2016-10-05 | Added | RELATION | is a GO:0043234 (protein complex) |
2016-06-22 | Added | RELATION | is a GO:0044424 (obsolete intracellular part) |
2016-06-22 | Added | RELATION | is a GO:1990234 (transferase complex) |
2016-06-22 | Deleted | RELATION | is a GO:0000151 (ubiquitin ligase complex) |
2015-06-25 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2015-06-25 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2015-06-18 | Added | RELATION | capable of GO:0004842 (ubiquitin-protein transferase activity) |
2014-06-05 | Added | RELATION | is a GO:0043234 (protein complex) |
2014-06-05 | Added | RELATION | is a GO:0044424 (obsolete intracellular part) |
2014-03-12 | Added | RELATION | is a GO:0000151 (ubiquitin ligase complex) |
2014-03-12 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | IntAct:EBI-9103673 |
2017-10-07 | Added | XREF | IntAct:EBI-9103673 |
Timestamp | Action | Category | Detail |
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