This term is obsolete.
This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.

GO:1990304 JSON

MUB1-RAD6-UBR2 ubiquitin ligase complex

Cellular Component

Definition (GO:1990304 GONUTS page)

A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. PMID:18070918

Comments

This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.

2,035 annotations

Ancestor Chart

Ancestor chart for GO:1990304
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Ancestor chart

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990304 based on ALL annotations
The top 95 of 95 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MUB1-RAD6-UBR2 ubiquitin ligase complex
96,076.29 100.00 2,029 2,029
RAD6-UBR2 ubiquitin ligase complex
96,076.28 11.88 241 241
UBR1-RAD6 ubiquitin ligase complex
90,872.16 11.12 227 240
regulation of dipeptide transport
90,872.16 11.12 227 240
stress-induced homeostatically regulated protein degradation pathway
73,929.88 10.82 227 295
error-free postreplication DNA repair
62,312.33 10.55 227 350
negative regulation of SREBP signaling pathway
51,469.44 10.12 225 420
establishment or maintenance of cell polarity
8,963.91 9.21 1,788 19,164
sno(s)RNA transcription
28,471.69 8.84 227 766
cytoplasm protein quality control by the ubiquitin-proteasome system
21,399.62 8.40 241 1,082
Totals 18421 214037244
No co-occurrence statistics for GO:1990304 based on MANUAL annotations
The top 47 of 47 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MUB1-RAD6-UBR2 ubiquitin ligase complex
75,988.18 100.00 17 17
RAD6-UBR2 ubiquitin ligase complex
75,988.17 11.76 2 2
UBR1-RAD6 ubiquitin ligase complex
37,994.09 5.56 1 2
regulation of dipeptide transport
37,994.09 5.56 1 2
stress-induced homeostatically regulated protein degradation pathway
15,197.64 4.76 1 5
cytoplasm protein quality control by the ubiquitin-proteasome system
5,240.56 4.55 2 29
positive regulation of flocculation
8,443.13 4.00 1 9
sno(s)RNA transcription
8,443.13 4.00 1 9
error-free postreplication DNA repair
3,618.48 2.70 1 21
sexual sporulation resulting in formation of a cellular spore
2,451.23 2.13 1 31
Totals 109 680741

Change Log

Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-9117531
2020-11-03 Added RELATION is a GO:0140535 (intracellular protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2019-08-30 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2019-08-30 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-08 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2017-10-07 Added XREF IntAct:EBI-9117531
2017-05-22 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2017-04-06 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
Timestamp Action Category Detail
2014-03-12 Added TERM MUB1-RAD6-UBR2 ubiquitin ligase complex
Timestamp Action Category Detail
2014-09-24 Added DEFINITION A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.
2014-09-24 Deleted DEFINITION A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ub-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.
2014-03-12 Added DEFINITION A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ub-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.
Timestamp Action Category Detail
2020-11-03 Added RELATION is a GO:0140535 (intracellular protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2019-08-30 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2019-08-30 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-08 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2017-05-22 Added RELATION part of GO:0005622 (intracellular anatomical structure)
2017-04-06 Deleted RELATION part of GO:0005622 (intracellular anatomical structure)
2016-10-05 Added RELATION is a GO:0043234 (protein complex)
2016-06-22 Deleted RELATION is a GO:0000151 (ubiquitin ligase complex)
2016-06-22 Added RELATION is a GO:1990234 (transferase complex)
2016-06-22 Added RELATION is a GO:0044424 (obsolete intracellular part)
2015-06-25 Deleted RELATION is a GO:0044424 (obsolete intracellular part)
2015-06-18 Added RELATION capable of GO:0004842 (ubiquitin-protein transferase activity)
2014-06-05 Added RELATION is a GO:0044424 (obsolete intracellular part)
2014-03-12 Added RELATION is a GO:0000151 (ubiquitin ligase complex)
2014-03-12 Added RELATION part of GO:0005622 (intracellular anatomical structure)
Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-9117531
2017-10-07 Added XREF IntAct:EBI-9117531
Timestamp Action Category Detail
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