This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
GO:1990304
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MUB1-RAD6-UBR2 ubiquitin ligase complex
Cellular Component
Definition (GO:1990304 GONUTS page)
A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. PMID:18070918
Comments
This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918.
Ancestor Chart
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990304 based on ALL annotations
The top 95 of 95 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MUB1-RAD6-UBR2 ubiquitin ligase complex
|
96,076.29 | 100.00 | 2,029 | 2,029 |
RAD6-UBR2 ubiquitin ligase complex
|
96,076.28 | 11.88 | 241 | 241 |
UBR1-RAD6 ubiquitin ligase complex
|
90,872.16 | 11.12 | 227 | 240 |
regulation of dipeptide transport
|
90,872.16 | 11.12 | 227 | 240 |
stress-induced homeostatically regulated protein degradation pathway
|
73,929.88 | 10.82 | 227 | 295 |
error-free postreplication DNA repair
|
62,312.33 | 10.55 | 227 | 350 |
negative regulation of SREBP signaling pathway
|
51,469.44 | 10.12 | 225 | 420 |
establishment or maintenance of cell polarity
|
8,963.91 | 9.21 | 1,788 | 19,164 |
sno(s)RNA transcription
|
28,471.69 | 8.84 | 227 | 766 |
cytoplasm protein quality control by the ubiquitin-proteasome system
|
21,399.62 | 8.40 | 241 | 1,082 |
Totals | 18421 | 214037244 |
No co-occurrence statistics for GO:1990304 based on MANUAL annotations
The top 47 of 47 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MUB1-RAD6-UBR2 ubiquitin ligase complex
|
75,988.18 | 100.00 | 17 | 17 |
RAD6-UBR2 ubiquitin ligase complex
|
75,988.17 | 11.76 | 2 | 2 |
UBR1-RAD6 ubiquitin ligase complex
|
37,994.09 | 5.56 | 1 | 2 |
regulation of dipeptide transport
|
37,994.09 | 5.56 | 1 | 2 |
stress-induced homeostatically regulated protein degradation pathway
|
15,197.64 | 4.76 | 1 | 5 |
cytoplasm protein quality control by the ubiquitin-proteasome system
|
5,240.56 | 4.55 | 2 | 29 |
positive regulation of flocculation
|
8,443.13 | 4.00 | 1 | 9 |
sno(s)RNA transcription
|
8,443.13 | 4.00 | 1 | 9 |
error-free postreplication DNA repair
|
3,618.48 | 2.70 | 1 | 21 |
sexual sporulation resulting in formation of a cellular spore
|
2,451.23 | 2.13 | 1 | 31 |
Totals | 109 | 680741 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | IntAct:EBI-9117531 |
2020-11-03 | Added | RELATION | is a GO:0140535 (intracellular protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2019-08-30 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2019-08-30 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-08 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-10-07 | Added | XREF | IntAct:EBI-9117531 |
2017-05-22 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-04-06 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-03-12 | Added | TERM | MUB1-RAD6-UBR2 ubiquitin ligase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-09-24 | Added | DEFINITION | A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. |
2014-09-24 | Deleted | DEFINITION | A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ub-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. |
2014-03-12 | Added | DEFINITION | A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ub-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Added | RELATION | is a GO:0140535 (intracellular protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2019-08-30 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2019-08-30 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-08 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-05-22 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2017-04-06 | Deleted | RELATION | part of GO:0005622 (intracellular anatomical structure) |
2016-10-05 | Added | RELATION | is a GO:0043234 (protein complex) |
2016-06-22 | Deleted | RELATION | is a GO:0000151 (ubiquitin ligase complex) |
2016-06-22 | Added | RELATION | is a GO:1990234 (transferase complex) |
2016-06-22 | Added | RELATION | is a GO:0044424 (obsolete intracellular part) |
2015-06-25 | Deleted | RELATION | is a GO:0044424 (obsolete intracellular part) |
2015-06-18 | Added | RELATION | capable of GO:0004842 (ubiquitin-protein transferase activity) |
2014-06-05 | Added | RELATION | is a GO:0044424 (obsolete intracellular part) |
2014-03-12 | Added | RELATION | is a GO:0000151 (ubiquitin ligase complex) |
2014-03-12 | Added | RELATION | part of GO:0005622 (intracellular anatomical structure) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | IntAct:EBI-9117531 |
2017-10-07 | Added | XREF | IntAct:EBI-9117531 |
Timestamp | Action | Category | Detail |
---|
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