This term is obsolete.

GO:1990316 JSON

Atg1/ULK1 kinase complex

Cellular Component

Definition (GO:1990316 GONUTS page)

A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. PMID:15743910 PMID:19211835 PMID:19258318 PMID:19597335 PMID:22885598

Secondary IDs

GO:0034273, GO:0070969

16,973 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATG1-ATG13 complex exact
autophagy-initiation complex exact
ATG1 kinase complex exact
ULK1 complex exact
ULK1-ATG13-FIP200 complex exact
Atg1p signalling complex exact
ULK complex exact
ULK1-ATG13-RB1CC1 complex exact
ULK1 signaling complex exact
ATG1/ULK1 signaling complex exact

Ancestor Chart

Ancestor chart for GO:1990316
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:1990316 Atg1/ULK1 kinase complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 237631 A0A0D1E8X3_USTMA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1L8G9S0 8355 A0A1L8G9S0_XENLA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4L3K3 6945 A0A1S4L3K3_IXOSC GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A2K5ATM2 6239 A0A2K5ATM2_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATM9 6239 A0A2K5ATM9_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATP6 6239 A0A2K5ATP6_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR018731 Autophagy-related protein 13, N-terminal

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:1990316 based on ALL annotations
The top 100 of 451 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Atg1/ULK1 kinase complex
11,643.70 100.00 16,742 16,742
protein localization to phagophore assembly site
5,360.53 25.48 6,083 13,213
ribophagy
7,970.91 25.47 4,831 7,057
piecemeal microautophagy of the nucleus
2,262.67 18.24 12,521 64,433
autophagosome assembly
1,747.97 14.94 16,204 107,939
phagophore assembly site
1,743.94 13.99 11,384 76,007
phagophore assembly site membrane
1,792.54 12.49 6,674 43,352
mitophagy
1,798.24 12.09 5,991 38,792
reticulophagy
1,692.47 10.87 5,038 34,660
autophagy
1,102.82 9.44 16,094 169,923
Totals 143158 2274175
No co-occurrence statistics for GO:1990316 based on MANUAL annotations
The top 100 of 240 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Atg1/ULK1 kinase complex
3,295.41 100.00 392 392
ribophagy
2,951.54 25.50 103 115
pexophagy
887.88 15.43 104 386
protein localization to phagophore assembly site
668.24 15.11 146 720
phagophore assembly site
518.04 14.72 274 1,743
protein kinase regulator activity
597.27 13.78 143 789
piecemeal microautophagy of the nucleus
440.04 12.59 270 2,022
phagophore assembly site membrane
446.96 10.31 118 870
autophagosome
349.18 9.18 160 1,510
reticulophagy
389.93 9.16 113 955
Totals 3257 49815

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2021-05-04 Deleted XREF IntAct:EBI-2352849
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2019-09-12 Added RELATION part of GO:0005737 (cytoplasm)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-10 Added DEFINITION A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2017-11-10 Added SYNONYM ULK1 complex
2017-11-10 Added SYNONYM ULK complex
2017-11-10 Deleted DEFINITION A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2017-11-09 Updated TERM Atg1/ULK1 kinase complex
Timestamp Action Category Detail
2017-11-09 Updated TERM Atg1/ULK1 kinase complex
2015-10-22 Updated TERM ATG1/ULK1 kinase complex
2014-08-09 Updated TERM ATG1/UKL1 kinase complex
2014-03-26 Added TERM ATG1 kinase complex
Timestamp Action Category Detail
2017-11-10 Added DEFINITION A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2017-11-10 Added SYNONYM ULK1 complex
2017-11-10 Added SYNONYM ULK complex
2017-11-10 Deleted DEFINITION A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2017-11-09 Deleted DEFINITION A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2017-11-09 Added DEFINITION A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2016-04-14 Added SYNONYM autophagy-initiation complex
2015-10-22 Deleted SYNONYM ATG1/UKL1 signaling complex
2015-10-22 Added DEFINITION A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2015-10-22 Deleted DEFINITION A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2015-10-22 Added SYNONYM ULK1 signaling complex
2015-10-22 Added SYNONYM ATG1/ULK1 signaling complex
2015-10-22 Deleted SYNONYM UKL1 signaling complex
2015-06-20 Added SYNONYM ULK1-ATG13-RB1CC1 complex
2015-06-20 Deleted DEFINITION A protein complex consisting of two subunits: ATG1/ULK1 and ATG13. This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2015-06-20 Added DEFINITION A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2015-06-20 Added SYNONYM ULK1-ATG13-FIP200 complex
2015-06-20 Added SYNONYM UKL1 signaling complex
2015-06-20 Added SYNONYM Atg1p signalling complex
2015-06-20 Added SYNONYM ATG1/UKL1 signaling complex
2014-08-09 Added DEFINITION A protein complex consisting of two subunits: ATG1/ULK1 and ATG13. This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.
2014-08-09 Deleted DEFINITION A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p and Atg13p.
2014-08-09 Added SYNONYM ATG1 kinase complex
2014-03-26 Added SYNONYM ATG1-ATG13 complex
2014-03-26 Added DEFINITION A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p and Atg13p.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2019-09-12 Added RELATION part of GO:0005737 (cytoplasm)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2017-11-08 Deleted RELATION capable of GO:0004674 (protein serine/threonine kinase activity)
2017-05-22 Added RELATION capable of GO:0004674 (protein serine/threonine kinase activity)
2017-04-06 Deleted RELATION capable of GO:0004674 (protein serine/threonine kinase activity)
2016-10-05 Added RELATION is a GO:0043234 (protein complex)
2015-06-25 Deleted RELATION is a GO:0043234 (protein complex)
2015-06-20 Deleted RELATION has part GO:0034273 (ATG1/UKL1 signaling complex)
2015-06-20 Added RELATION is a GO:0044444 (obsolete cytoplasmic part)
2015-06-18 Added RELATION capable of part of GO:0000045 (autophagosome assembly)
2015-06-18 Added RELATION capable of GO:0004674 (protein serine/threonine kinase activity)
2014-08-09 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2014-08-09 Added RELATION is a GO:0043234 (protein complex)
2014-08-09 Added RELATION has part GO:0034273 (ATG1/UKL1 signaling complex)
2014-08-09 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2014-08-09 Deleted RELATION is a GO:0044425 (obsolete membrane part)
2014-08-09 Deleted RELATION part of GO:0034273 (ATG1/UKL1 signaling complex)
2014-08-09 Deleted RELATION is a GO:1902494 (catalytic complex)
2014-08-09 Deleted RELATION part of GO:0034045 (phagophore assembly site membrane)
2014-03-26 Added RELATION is a GO:1902494 (catalytic complex)
2014-03-26 Added RELATION is a GO:0044444 (obsolete cytoplasmic part)
2014-03-26 Added RELATION is a GO:0044425 (obsolete membrane part)
2014-03-26 Added RELATION part of GO:0034273 (ATG1/UKL1 signaling complex)
2014-03-26 Added RELATION part of GO:0034045 (phagophore assembly site membrane)
Timestamp Action Category Detail
2021-05-04 Deleted XREF IntAct:EBI-2352849
2017-10-07 Added XREF IntAct:EBI-2352849
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2015-06-20 Added SECONDARY GO:0070969 (ULK1-ATG13-FIP200 complex)
2015-06-20 Added SECONDARY GO:0034273 (ATG1/UKL1 signaling complex)
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