GO:1990316
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Atg1/ULK1 kinase complex
Cellular Component
Definition (GO:1990316 GONUTS page)
A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. PMID:15743910 PMID:19211835 PMID:19258318 PMID:19597335 PMID:22885598
Secondary IDs
GO:0034273, GO:0070969
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATG1-ATG13 complex | exact |
autophagy-initiation complex | exact |
ATG1 kinase complex | exact |
ULK1 complex | exact |
ULK1-ATG13-FIP200 complex | exact |
Atg1p signalling complex | exact |
ULK complex | exact |
ULK1-ATG13-RB1CC1 complex | exact |
ULK1 signaling complex | exact |
ATG1/ULK1 signaling complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:1990316 | Atg1/ULK1 kinase complex | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 237631 | A0A0D1E8X3_USTMA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1L8G9S0 | 8355 | A0A1L8G9S0_XENLA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4L3K3 | 6945 | A0A1S4L3K3_IXOSC | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A2K5ATM2 | 6239 | A0A2K5ATM2_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATM9 | 6239 | A0A2K5ATM9_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATP6 | 6239 | A0A2K5ATP6_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR018731 | Autophagy-related protein 13, N-terminal |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:1990316 based on ALL annotations
The top 100 of 451 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Atg1/ULK1 kinase complex
|
11,643.70 | 100.00 | 16,742 | 16,742 |
protein localization to phagophore assembly site
|
5,360.53 | 25.48 | 6,083 | 13,213 |
ribophagy
|
7,970.91 | 25.47 | 4,831 | 7,057 |
piecemeal microautophagy of the nucleus
|
2,262.67 | 18.24 | 12,521 | 64,433 |
autophagosome assembly
|
1,747.97 | 14.94 | 16,204 | 107,939 |
phagophore assembly site
|
1,743.94 | 13.99 | 11,384 | 76,007 |
phagophore assembly site membrane
|
1,792.54 | 12.49 | 6,674 | 43,352 |
mitophagy
|
1,798.24 | 12.09 | 5,991 | 38,792 |
reticulophagy
|
1,692.47 | 10.87 | 5,038 | 34,660 |
autophagy
|
1,102.82 | 9.44 | 16,094 | 169,923 |
Totals | 143158 | 2274175 |
No co-occurrence statistics for GO:1990316 based on MANUAL annotations
The top 100 of 240 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Atg1/ULK1 kinase complex
|
3,295.41 | 100.00 | 392 | 392 |
ribophagy
|
2,951.54 | 25.50 | 103 | 115 |
pexophagy
|
887.88 | 15.43 | 104 | 386 |
protein localization to phagophore assembly site
|
668.24 | 15.11 | 146 | 720 |
phagophore assembly site
|
518.04 | 14.72 | 274 | 1,743 |
protein kinase regulator activity
|
597.27 | 13.78 | 143 | 789 |
piecemeal microautophagy of the nucleus
|
440.04 | 12.59 | 270 | 2,022 |
phagophore assembly site membrane
|
446.96 | 10.31 | 118 | 870 |
autophagosome
|
349.18 | 9.18 | 160 | 1,510 |
reticulophagy
|
389.93 | 9.16 | 113 | 955 |
Totals | 3257 | 49815 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2021-05-04 | Deleted | XREF | IntAct:EBI-2352849 |
2019-09-12 | Deleted | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2019-09-12 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-10 | Added | DEFINITION | A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2017-11-10 | Added | SYNONYM | ULK1 complex |
2017-11-10 | Added | SYNONYM | ULK complex |
2017-11-10 | Deleted | DEFINITION | A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2017-11-09 | Updated | TERM | Atg1/ULK1 kinase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-09 | Updated | TERM | Atg1/ULK1 kinase complex |
2015-10-22 | Updated | TERM | ATG1/ULK1 kinase complex |
2014-08-09 | Updated | TERM | ATG1/UKL1 kinase complex |
2014-03-26 | Added | TERM | ATG1 kinase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-10 | Added | DEFINITION | A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2017-11-10 | Added | SYNONYM | ULK1 complex |
2017-11-10 | Added | SYNONYM | ULK complex |
2017-11-10 | Deleted | DEFINITION | A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2017-11-09 | Deleted | DEFINITION | A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2017-11-09 | Added | DEFINITION | A protein complex consisting of Atg1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2016-04-14 | Added | SYNONYM | autophagy-initiation complex |
2015-10-22 | Deleted | SYNONYM | ATG1/UKL1 signaling complex |
2015-10-22 | Added | DEFINITION | A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2015-10-22 | Deleted | DEFINITION | A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2015-10-22 | Added | SYNONYM | ULK1 signaling complex |
2015-10-22 | Added | SYNONYM | ATG1/ULK1 signaling complex |
2015-10-22 | Deleted | SYNONYM | UKL1 signaling complex |
2015-06-20 | Added | SYNONYM | ULK1-ATG13-RB1CC1 complex |
2015-06-20 | Deleted | DEFINITION | A protein complex consisting of two subunits: ATG1/ULK1 and ATG13. This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2015-06-20 | Added | DEFINITION | A protein complex consisting of ATG1/UKL1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2015-06-20 | Added | SYNONYM | ULK1-ATG13-FIP200 complex |
2015-06-20 | Added | SYNONYM | UKL1 signaling complex |
2015-06-20 | Added | SYNONYM | Atg1p signalling complex |
2015-06-20 | Added | SYNONYM | ATG1/UKL1 signaling complex |
2014-08-09 | Added | DEFINITION | A protein complex consisting of two subunits: ATG1/ULK1 and ATG13. This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. |
2014-08-09 | Deleted | DEFINITION | A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p and Atg13p. |
2014-08-09 | Added | SYNONYM | ATG1 kinase complex |
2014-03-26 | Added | SYNONYM | ATG1-ATG13 complex |
2014-03-26 | Added | DEFINITION | A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p and Atg13p. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2019-09-12 | Added | RELATION | part of GO:0005737 (cytoplasm) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2017-11-08 | Deleted | RELATION | capable of GO:0004674 (protein serine/threonine kinase activity) |
2017-05-22 | Added | RELATION | capable of GO:0004674 (protein serine/threonine kinase activity) |
2017-04-06 | Deleted | RELATION | capable of GO:0004674 (protein serine/threonine kinase activity) |
2016-10-05 | Added | RELATION | is a GO:0043234 (protein complex) |
2015-06-25 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2015-06-20 | Deleted | RELATION | has part GO:0034273 (ATG1/UKL1 signaling complex) |
2015-06-20 | Added | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2015-06-18 | Added | RELATION | capable of part of GO:0000045 (autophagosome assembly) |
2015-06-18 | Added | RELATION | capable of GO:0004674 (protein serine/threonine kinase activity) |
2014-08-09 | Added | RELATION | is a GO:1902554 (serine/threonine protein kinase complex) |
2014-08-09 | Added | RELATION | is a GO:0043234 (protein complex) |
2014-08-09 | Added | RELATION | has part GO:0034273 (ATG1/UKL1 signaling complex) |
2014-08-09 | Deleted | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2014-08-09 | Deleted | RELATION | is a GO:0044425 (obsolete membrane part) |
2014-08-09 | Deleted | RELATION | part of GO:0034273 (ATG1/UKL1 signaling complex) |
2014-08-09 | Deleted | RELATION | is a GO:1902494 (catalytic complex) |
2014-08-09 | Deleted | RELATION | part of GO:0034045 (phagophore assembly site membrane) |
2014-03-26 | Added | RELATION | is a GO:1902494 (catalytic complex) |
2014-03-26 | Added | RELATION | is a GO:0044444 (obsolete cytoplasmic part) |
2014-03-26 | Added | RELATION | is a GO:0044425 (obsolete membrane part) |
2014-03-26 | Added | RELATION | part of GO:0034273 (ATG1/UKL1 signaling complex) |
2014-03-26 | Added | RELATION | part of GO:0034045 (phagophore assembly site membrane) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-04 | Deleted | XREF | IntAct:EBI-2352849 |
2017-10-07 | Added | XREF | IntAct:EBI-2352849 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2015-06-20 | Added | SECONDARY | GO:0070969 (ULK1-ATG13-FIP200 complex) |
2015-06-20 | Added | SECONDARY | GO:0034273 (ATG1/UKL1 signaling complex) |
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