GO:2000272
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negative regulation of signaling receptor activity
Biological Process
Definition (GO:2000272 GONUTS page)
Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.
Restrictions
This term should not be used for direct annotation.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation of receptor activity | broad |
negative regulation of signalling receptor activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:2000272
Child Term | Relationship to GO:2000272 |
---|---|
negative regulation of NMDA glutamate receptor activity
|
is_a |
negative regulation of AMPA receptor activity
|
is_a |
negative regulation of advanced glycation end-product receptor activity
|
is_a |
cross-receptor inhibition within G protein-coupled receptor heterodimer
|
is_a |
negative regulation of corticotropin-releasing hormone receptor activity
|
is_a |
negative regulation of epidermal growth factor-activated receptor activity
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:2000272 based on ALL annotations
The top 100 of 372 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of signaling receptor activity
|
22,017,208.00 | 100.00 | 9 | 9 |
negative regulation of interleukin-11 production
|
11,008,604.00 | 10.00 | 1 | 2 |
positive regulation of ferrous iron binding
|
11,008,604.00 | 10.00 | 1 | 2 |
positive regulation of transferrin receptor binding
|
11,008,604.00 | 10.00 | 1 | 2 |
positive regulation of calcidiol 1-monooxygenase activity
|
5,504,302.00 | 8.33 | 1 | 4 |
positive regulation of receptor binding
|
4,403,441.50 | 7.69 | 1 | 5 |
negative regulation of bile acid secretion
|
3,145,315.50 | 6.67 | 1 | 7 |
positive regulation of signaling receptor activity
|
3,145,315.50 | 6.67 | 1 | 7 |
transmembrane receptor protein tyrosine kinase inhibitor activity
|
2,752,151.00 | 6.25 | 1 | 8 |
negative regulation of cytotoxic T cell differentiation
|
2,752,151.00 | 6.25 | 1 | 8 |
Totals | 112 | 29992 |
No co-occurrence statistics for GO:2000272 based on MANUAL annotations
The top 100 of 252 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of signaling receptor activity
|
156,837.00 | 100.00 | 9 | 9 |
negative regulation of interleukin-11 production
|
78,418.50 | 10.00 | 1 | 2 |
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
|
78,418.50 | 10.00 | 1 | 2 |
negative regulation of branching involved in lung morphogenesis
|
78,418.50 | 10.00 | 1 | 2 |
positive regulation of interleukin-33 production
|
78,418.50 | 10.00 | 1 | 2 |
positive regulation of ferrous iron binding
|
78,418.50 | 10.00 | 1 | 2 |
positive regulation of transferrin receptor binding
|
78,418.50 | 10.00 | 1 | 2 |
signaling receptor inhibitor activity
|
16,224.52 | 8.57 | 3 | 29 |
positive regulation of calcidiol 1-monooxygenase activity
|
39,209.25 | 8.33 | 1 | 4 |
positive regulation of vitamin D biosynthetic process
|
39,209.25 | 8.33 | 1 | 4 |
Totals | 115 | 4322 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
2020-11-24 | Added | SYNONYM | negative regulation of signalling receptor activity |
2018-07-12 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2018-03-05 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2018-03-05 | Added | RELATION | negatively regulates GO:0038023 (signaling receptor activity) |
2018-03-05 | Deleted | RELATION | negatively regulates GO:0004872 (receptor activity) |
2018-03-05 | Updated | TERM | negative regulation of signaling receptor activity |
2018-03-05 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Updated | TERM | negative regulation of signaling receptor activity |
2010-12-05 | Added | TERM | negative regulation of receptor activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-24 | Added | SYNONYM | negative regulation of signalling receptor activity |
2018-03-05 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. |
2018-03-05 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. |
2018-03-05 | Added | SYNONYM | negative regulation of receptor activity |
2010-12-05 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-12 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2018-03-05 | Added | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2018-03-05 | Added | RELATION | negatively regulates GO:0038023 (signaling receptor activity) |
2018-03-05 | Deleted | RELATION | negatively regulates GO:0004872 (receptor activity) |
2010-12-05 | Added | RELATION | is a GO:0010469 (regulation of signaling receptor activity) |
2010-12-05 | Added | RELATION | is a GO:0044092 (negative regulation of molecular function) |
2010-12-05 | Added | RELATION | negatively regulates GO:0004872 (receptor activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
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