This term is obsolete.

GO:2001107 JSON

negative regulation of Rho guanyl-nucleotide exchange factor activity

Biological Process

Definition (GO:2001107 GONUTS page)

Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.

Restrictions

This term should not be used for direct annotation.

8 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of Rho guanine nucleotide exchange factor exact
negative regulation of RhoGEF exact

Ancestor Chart

Ancestor chart for GO:2001107
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q96PC5-7 9606 MIA2_HUMAN GO:1905097 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25202031

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:2001107 based on ALL annotations
The top 37 of 37 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of Rho guanyl-nucleotide exchange factor activity
27,848,398.00 100.00 7 7
negative regulation of establishment of T cell polarity
27,848,398.00 100.00 7 7
negative regulation of protein localization to cell leading edge
2,240,675.80 8.05 7 87
negative regulation of T cell migration
628,834.75 2.26 7 310
positive regulation of myoblast fusion
181,169.88 0.65 7 1,076
cellular response to chemokine
155,206.03 0.56 7 1,256
positive regulation of neutrophil extravasation
122,989.77 0.44 7 1,585
positive regulation of neutrophil chemotaxis
107,463.50 0.39 7 1,814
14-3-3 protein binding
70,425.86 0.25 7 2,768
stereocilium membrane
59,523.29 0.21 7 3,275
Totals 212 65624563
No co-occurrence statistics for GO:2001107 based on MANUAL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of Rho guanyl-nucleotide exchange factor activity
184,542.70 100.00 7 7
negative regulation of protein localization to cell leading edge
184,542.70 100.00 7 7
negative regulation of establishment of T cell polarity
184,542.70 100.00 7 7
stereocilium membrane
73,817.09 20.00 2 5
positive regulation of neutrophil extravasation
25,835.98 14.00 7 50
negative regulation of T cell migration
23,487.25 12.73 7 55
cellular response to chemokine
14,848.27 8.05 7 87
positive regulation of myoblast fusion
14,353.32 7.78 7 90
positive regulation of neutrophil chemotaxis
11,533.92 6.25 7 112
regulation of establishment of cell polarity
8,728.37 4.73 7 148
Totals 151 326879

Change Log

Timestamp Action Category Detail
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
2020-10-25 Deleted RELATION negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
2020-10-25 Deleted RELATION is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity)
2020-10-25 Deleted RELATION is a GO:1904476 (negative regulation of small GTPase binding)
2017-09-30 Added RELATION is a GO:1904476 (negative regulation of small GTPase binding)
2016-04-06 Added RELATION is a GO:1905098 (negative regulation of guanyl-nucleotide exchange factor activity)
2016-04-06 Deleted RELATION is a GO:0044092 (negative regulation of molecular function)
2016-04-06 Deleted RELATION is a GO:0051099 (positive regulation of binding)
Timestamp Action Category Detail
2011-09-30 Added TERM negative regulation of Rho guanyl-nucleotide exchange factor activity
Timestamp Action Category Detail
2011-09-30 Added SYNONYM negative regulation of Rho guanine nucleotide exchange factor
2011-09-30 Added SYNONYM negative regulation of RhoGEF
2011-09-30 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
Timestamp Action Category Detail
2020-10-25 Deleted RELATION negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
2020-10-25 Deleted RELATION is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity)
2020-10-25 Deleted RELATION is a GO:1904476 (negative regulation of small GTPase binding)
2017-09-30 Added RELATION is a GO:1904476 (negative regulation of small GTPase binding)
2016-04-06 Added RELATION is a GO:1905098 (negative regulation of guanyl-nucleotide exchange factor activity)
2016-04-06 Deleted RELATION is a GO:0044092 (negative regulation of molecular function)
2016-04-06 Deleted RELATION is a GO:0051099 (positive regulation of binding)
2016-04-06 Deleted RELATION is a GO:0048519 (negative regulation of biological process)
2016-01-10 Added RELATION is a GO:0051099 (positive regulation of binding)
2014-10-18 Added RELATION is a GO:0048519 (negative regulation of biological process)
2011-09-30 Added RELATION is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity)
2011-09-30 Added RELATION is a GO:0044092 (negative regulation of molecular function)
2011-09-30 Added RELATION negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.