GO:2001107
JSON
negative regulation of Rho guanyl-nucleotide exchange factor activity
Biological Process
Definition (GO:2001107 GONUTS page)
Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
Restrictions
This term should not be used for direct annotation.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| negative regulation of Rho guanine nucleotide exchange factor | exact |
| negative regulation of RhoGEF | exact |
Ancestor Chart
Ancestor chart for GO:2001107
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Binding term considerations | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | Q96PC5-7 | 9606 | MIA2_HUMAN | GO:1905097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25202031 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:2001107 based on ALL annotations
The top 37 of 37 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
negative regulation of Rho guanyl-nucleotide exchange factor activity
|
28,307,838.00 | 100.00 | 7 | 7 |
|
negative regulation of establishment of T cell polarity
|
28,307,838.00 | 100.00 | 7 | 7 |
|
negative regulation of protein localization to cell leading edge
|
2,277,642.00 | 8.05 | 7 | 87 |
|
negative regulation of T cell migration
|
647,564.94 | 2.29 | 7 | 306 |
|
positive regulation of myoblast fusion
|
183,817.12 | 0.65 | 7 | 1,078 |
|
cellular response to chemokine
|
158,397.17 | 0.56 | 7 | 1,251 |
|
positive regulation of neutrophil extravasation
|
123,077.56 | 0.43 | 7 | 1,610 |
|
positive regulation of neutrophil chemotaxis
|
109,236.42 | 0.39 | 7 | 1,814 |
|
14-3-3 protein binding
|
71,125.22 | 0.25 | 7 | 2,786 |
|
stereocilium membrane
|
59,133.06 | 0.21 | 7 | 3,351 |
| Totals | 214 | 66585573 | ||
No co-occurrence statistics for GO:2001107 based on MANUAL annotations
The top 29 of 29 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
negative regulation of Rho guanyl-nucleotide exchange factor activity
|
201,647.58 | 100.00 | 7 | 7 |
|
negative regulation of protein localization to cell leading edge
|
201,647.58 | 100.00 | 7 | 7 |
|
negative regulation of establishment of T cell polarity
|
201,647.58 | 100.00 | 7 | 7 |
|
stereocilium membrane
|
80,659.03 | 20.00 | 2 | 5 |
|
negative regulation of T cell migration
|
27,677.12 | 13.73 | 7 | 51 |
|
positive regulation of neutrophil extravasation
|
23,139.89 | 11.48 | 7 | 61 |
|
cellular response to chemokine
|
17,006.42 | 8.43 | 7 | 83 |
|
positive regulation of myoblast fusion
|
15,683.70 | 7.78 | 7 | 90 |
|
positive regulation of neutrophil chemotaxis
|
12,602.97 | 6.25 | 7 | 112 |
|
regulation of establishment of cell polarity
|
9,225.71 | 4.58 | 7 | 153 |
| Totals | 152 | 351802 | ||
Change Log
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- Definition / Synonyms
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
| 2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
| 2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
| 2020-10-25 | Deleted | RELATION | negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity) |
| 2020-10-25 | Deleted | RELATION | is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity) |
| 2020-10-25 | Deleted | RELATION | is a GO:1904476 (obsolete negative regulation of small GTPase binding) |
| 2017-09-30 | Added | RELATION | is a GO:1904476 (obsolete negative regulation of small GTPase binding) |
| 2016-04-06 | Added | RELATION | is a GO:1905098 (negative regulation of guanyl-nucleotide exchange factor activity) |
| 2016-04-06 | Deleted | RELATION | is a GO:0044092 (negative regulation of molecular function) |
| 2016-04-06 | Deleted | RELATION | is a GO:0051099 (positive regulation of binding) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-09-30 | Added | TERM | negative regulation of Rho guanyl-nucleotide exchange factor activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2011-09-30 | Added | SYNONYM | negative regulation of Rho guanine nucleotide exchange factor |
| 2011-09-30 | Added | SYNONYM | negative regulation of RhoGEF |
| 2011-09-30 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2020-10-25 | Deleted | RELATION | negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity) |
| 2020-10-25 | Deleted | RELATION | is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity) |
| 2020-10-25 | Deleted | RELATION | is a GO:1904476 (obsolete negative regulation of small GTPase binding) |
| 2017-09-30 | Added | RELATION | is a GO:1904476 (obsolete negative regulation of small GTPase binding) |
| 2016-04-06 | Added | RELATION | is a GO:1905098 (negative regulation of guanyl-nucleotide exchange factor activity) |
| 2016-04-06 | Deleted | RELATION | is a GO:0044092 (negative regulation of molecular function) |
| 2016-04-06 | Deleted | RELATION | is a GO:0051099 (positive regulation of binding) |
| 2016-04-06 | Deleted | RELATION | is a GO:0048519 (negative regulation of biological process) |
| 2016-01-10 | Added | RELATION | is a GO:0051099 (positive regulation of binding) |
| 2014-10-18 | Added | RELATION | is a GO:0048519 (negative regulation of biological process) |
| 2011-09-30 | Added | RELATION | is a GO:2001106 (regulation of Rho guanyl-nucleotide exchange factor activity) |
| 2011-09-30 | Added | RELATION | is a GO:0044092 (negative regulation of molecular function) |
| 2011-09-30 | Added | RELATION | negatively regulates GO:0005089 (Rho guanyl-nucleotide exchange factor activity) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
| 2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
| 2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
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