ID AF079457; SV 1; linear; genomic RNA; STD; VRL; 11821 BP. XX AC AF079457; XX DT 06-AUG-1998 (Rel. 56, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Igbo Ora virus strain IBH10964, complete genome. XX KW . XX OS Igbo Ora virus OC Viruses; Riboviria; Togaviridae; Alphavirus. XX RN [1] RP 1-11821 RX DOI; 10.1006/viro.1998.9437. RX PUBMED; 9875334. RA Lanciotti R.S., Ludwig M.L., Rwaguma E.B., Lutwama J.J., Kram T.M., RA Karabatsos N., Cropp B.C., Miller B.R.; RT "Emergence of epidemic O'nyong-nyong fever in Uganda after a 35-year RT absence: genetic characterization of the virus"; RL Virology 252(1):258-268(1998). XX RN [2] RP 1-11821 RA Lanciotti R.S., Ludwig M.L., Rwanuma E.B., Lutwama J.J., Kram T.M., RA Karabatsos N., Cropp B.C., Miller B.R.; RT ; RL Submitted (21-JUL-1998) to the INSDC. RL Division of Vector-Borne Diseases, Centers for Disease Control and RL Prevention, Rampart Rd, Fort Collins, CO 80521, USA XX DR MD5; 5d0d87f60d36bc2a08fc75f0bb27001d. DR EuropePMC; PMC136221; 12021349. DR EuropePMC; PMC2569925; 18822126. DR EuropePMC; PMC4259830; 25463613. DR RFAM; RF00470; Toga_5_CRE. XX FH Key Location/Qualifiers FH FT source 1..11821 FT /organism="Igbo Ora virus" FT /strain="IBH10964" FT /mol_type="genomic RNA" FT /country="Nigeria" FT /note="isolated in 1966 from a human febrile patient" FT /db_xref="taxon:79899" FT mat_peptide 80..1684 FT /product="nonstructural protein 1" FT /note="nsP1" FT CDS 80..7621 FT /codon_start=1 FT /product="nonstructural polyprotein" FT /db_xref="GOA:O90370" FT /db_xref="InterPro:IPR001788" FT /db_xref="InterPro:IPR002588" FT /db_xref="InterPro:IPR002589" FT /db_xref="InterPro:IPR002620" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027417" FT /db_xref="UniProtKB/Swiss-Prot:O90370" FT /protein_id="AAC97206.1" FT /translation="MDSVYVDIDADSAFLKALQRAYPMFEVEPKQVTPNDHANARAFSH FT LAIKLIEQEIDPGSTILGIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLASAA FT GKVTDKNISGKINDLQAVMAVPNMETSTFCLHTDATCKQRGDVAIYQDVYAVHAPTSLY FT HQAIKGVHVAYWIGFDTTPFMYNAMAGAYPSYSTNWADEQVLKAKNIGLCSTDLSEGRR FT GKLSIMRGKKFKPCDRVLFSVGSTLYPESRKLLQSWHLPSVFHLKGKLSFTCRCDTIVS FT CEGYVVKRVTMSPGIYGKTSGYAVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICD FT QMTGILATEVTPEDAQKLLVGLNQRIVVNGRTQRNTNTMKNYLLPIVAQAFSKWAKECR FT KDMEDEKLLGVRERTLTCCCLWAFRKHKTHTVYKRPDTQSIQKVPAEFDSFVIPSLWSS FT GLSIPLRTRIKWLLSKAPKHEQLPHSGNAEEAAQAETDAVEEREAELTREAMPPLQATQ FT DDVQVEIDVEQLEDRAGAGIVETPRGAIKVTAQPSDLVVGEYLVLTPQAVLRSQKLGLI FT HALAEQVKTCTHSGRAGRYAVEAYDGRVLVPSGYAIPQEDFQSLSESATMVFNEREFVN FT RKLHHIAMHGPALNTDEESYELVRVEKTEHEYVYDVDQKKCCKREEATGLVLVGDLTSP FT PYHEFAYEGLKIRPACPYKTAVIGVFGVPGSGKSAIIKNLVTRQDLVTSGKKENCQEIS FT NDVMRQRKLEISARTVDSLLLNGCNKPVEVLYVDEAFACHSGTLLALIAMVRPRQKVVL FT CGDPKQCGFFNMMQMKVNYNHNICTQVYHKSISRRCTLPVTAIVSSLHYESKMRTTNEY FT NQPIVVDTTGTTKPEPGDLVLTCFRGWVKQLQIDYRGNEVMTAAASQGLTRKGVYAVRQ FT KVNENPLYASTSEHVNVLLTRTEGKLIWKTLSGDPWIKILQNPPKGNFKATIKEWEAEH FT ASIMAGICNYQMAFDTFQNKANVCWAKCLVPILDTAGIKLSDRQWSQIVQAFKEDRAYS FT PEVALNEICTRIYGVDLDSGLFSKPLISVYYADNHWDNRPGGKMFGFNPEVALMLEKKY FT PFTKGKWNINKQICITTRKVDEFNPETNIIPANRRLPHSLVAEHHSVRGERMEWLVNKI FT NGHHMLLVSGYNLILPTKRVTWVAPLGTRGADYTYNLELGLPATLGRYDLVVINIHTPF FT RIHHYQQCVDHAMKLQMLGGDSLRLLKPGGSLLIRAYGYADRTSERVISVLGRKFRSSR FT ALKPQCITSNTEMFFLFSRFDNGRRNFTTHVMNNQLNAVYAGLATRAGCAPSYRVKRMD FT IAKNTEECVVNAANPRGVPGDGVCKAVYRKWPESFRNSATPVGTAKTIMCGQYPVIHAV FT GPNFSNYSEAEGDRELASAYREVAKEVSRLGVSSVAIPLLSTGVYSGGKDRLLQSLNHL FT FAAMDSTDADVVIYCRDKEWEKKITEAISLRSQVELLDDHISVDCDIVRVHPDSSLAGR FT KGYSTVEGALYSYLEGTRFHQTAVDMAEIYTMWPKQTEANEQVCLYALGESIESVRQKC FT PVDDADASFPPKTVPCLCRYAMTPERVARLRMNHTTSIIVCSSFPLPKYKIEGVQKVKC FT SKALLFDHNVPSRVSPRTYRPADEIIQTPQISTEACQDAQLVQSINDEAVPVPSDLEAC FT DATMDWPSIGTVPTRQRHDSFDSEYSSRSNIQLVTADVHAPMYANSLASSGGSMLSLSS FT EPAQNGIMILPDSEDTDSISRVSTPIAPPRRRLGRTINVTCDEREGKILPMASDRFFTA FT KPYTVALSVSTADITAYPIQAPLGLTQPPTLEQITFGDFAEGEIDNLLTGALTFGDFEP FT GEVEELTDSEWSTCSDTDEELRLDRAGGYIFSSDTGQGHLQQKSVRQTTLPVNIVEEVH FT EEKCYPPKLDETKEQLLLKRLQESASTANRSRYQSRKVENMKATIIHRLKEGCRLYLAS FT DTPRVPSYRITYPAPVYSPSINIKLSNPETAVAVCNEFLARNYPTVASYQVTDEYDAYL FT DMVDGSESCLDRATFNPSKLRSYPKQHSYHAPTIRSAVPSPFQNTLQNVLAAATKRNCN FT VTQMRELPTMDSAVFNVECFKKYACNQEYWREFASSPIRVTTENLTMYVTKLKGPKAAA FT LFAKTHNLLPLQEVPMDRFTMDMKRDVKVTPGTKHTEERPKVQVIQAAEPLATAYLCGI FT HRELVRRLNAVLLPNVHTLFDMSAEDFDAIIATHFKPGDAVLETDIASFDKSQDDSLAL FT TAMMLLEDLGVDQPILDLIEAAFGEISSCHLPTGTRFKFGAMMKSGMFLTLFVNTLLNI FT TIASRVLEERLTTSACAAFIGDDNIIHGVVSDALMAARCATWMNMEVKIIDAVVSEKAP FT YFCGGFILHDTVTGTSCRVADPLKRLFKLGKPLAAGDEQDEDRRRALADEVTRWQRTGL FT VTELEKAVYSRYEVQGITAVITSMATFASSKENFKKLRGPVVTLYGGPK" FT mat_peptide 1685..4078 FT /product="nonstructural protein 2" FT /note="nsP2" FT mat_peptide 4079..5785 FT /product="nonstructural protein 3" FT /note="nsP3" FT mat_peptide 5786..7618 FT /product="nonstructural protein 4" FT /note="nsP4" FT mat_peptide 7668..8447 FT /product="capsid protein" FT /note="nucleocapsid protein" FT CDS 7668..11411 FT /codon_start=1 FT /product="structural polyprotein" FT /db_xref="GOA:O90371" FT /db_xref="InterPro:IPR000336" FT /db_xref="InterPro:IPR000930" FT /db_xref="InterPro:IPR000936" FT /db_xref="InterPro:IPR002533" FT /db_xref="InterPro:IPR002548" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014756" FT /db_xref="InterPro:IPR036253" FT /db_xref="InterPro:IPR038055" FT /db_xref="InterPro:IPR042304" FT /db_xref="InterPro:IPR042305" FT /db_xref="InterPro:IPR042306" FT /db_xref="UniProtKB/Swiss-Prot:O90371" FT /protein_id="AAC97207.1" FT /translation="MEFIPAQTYYNRRYQPRPWTQRPTIQVIRPKPRRRRPAGQLAQLI FT SAVSRLALRTVPQKPRRTRKIKKQKQVKQEQQSTRNQKKKAPKQKQTQKKKRPGRRERM FT CMKIENDCIFEVKHEGKVTGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLEC FT AQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGR FT VVAIVLGGANEGTRTALSVVTWNKDIVTKITPEGSVEWSLALPVMCLLANTTFPCSQPP FT CAPCCYEKKPEETLRMLEDNVMQPGYYQLLDSALACSQHRQRRNARENFNVYKVTRPYL FT AHCPDCGEGHSCHSPIALERIRSEATDGTLKIQVSLQIGIKTADSHDWTKLRYMDSHTP FT VDADRSGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFVDSRRISHTCMHPFHHEPP FT LIGREKFHSRPQHGKELPCSTYVHTTAATTEEIEVHMPPDTPDYTLMTQQAGNVKITVD FT GQTVRYKCKCDGSNEGLITTDKVINNCKVDQCHTAVTNHKKWQYNSPLTPRNSEQGDRK FT GKIHIPFPLVNTTCRVPKARNPTVTYGKNRVTLLLYPDHPTLLSYRAMGRIPDYHEEWI FT TSKKEISITVPAEGLEVTWGNNDPYKYWPQLSTNGTAHGHPHEIILYYYELYPTTTIAV FT LAAASIVVASLVGLSLGMCICARRRCITPYELTPGATIPFLLGILCCVKTAKAASYYEA FT ATYLWNEQQPLFWLQLLIPLSAAIVVCNCLKLLPCCCKTLTFLAVMSIGARTVSAYEHA FT TVIPNTVGVPYKTLVSRPGYSPMVLEMELQSVTLEPTLFLDYITCEYKTITPSPYVKCC FT GTAECKAKNLPDYNCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAY FT RAHTASVSAKLRVFYQGNNITVSAYANGDHAVTVKDAKFVIGPLSSAWSPFDNKIVVYK FT GEVYNMDYPPFGAGRPGQFGDIQSRTPDSKDVYANTQLILQRPAAGAIHVPYSQAPSGF FT KYWLKEKGASLQHTAPFGCQIATNPVRAVNCAVGNIPVSIDIPDAAFTRVTDAPSVTDM FT SCEVASCTHSSDFGGAAVIKYTASKKGKCAVHSLTNAVTIREPNVDVEGTAQLQIAFST FT ALASAEFKVQICSTQVHCSATCHPPKDHIVNYPSPHTTLGVQDISTTAMSWVQKITGGV FT GLVVAIAALILIIVLCVSFSRH" FT mat_peptide 8448..8639 FT /product="envelope protein" FT /note="E3" FT mat_peptide 8640..9908 FT /product="envelope glycoprotein" FT /note="E2" FT mat_peptide 9909..10091 FT /product="envelope protein" FT /note="6K protein" FT mat_peptide 10092..11408 FT /product="envelope glycoprotein" FT /note="E1" XX SQ Sequence 11821 BP; 3672 A; 2834 C; 2850 G; 2465 T; 0 other; atggctgcgt gacacacaca cgcagcttac gggtatcata ctgctctact ctgcattgca 60 agagattaaa gtacccatca tggattcagt gtatgtagac atagatgctg acagcgcgtt 120 tctgaaggcg ttgcagcgag cataccccat gtttgaggtg gaaccaaagc aggtcacgcc 180 aaacgaccat gcaaacgcta gagcattttc gcatctagca ataaaactga tagagcagga 240 aatcgatcca ggctcaacca ttctaggcat tggtagtgca ccagctagga ggatgatgtc 300 tgatagaaaa taccactgcg tctgcccgat gcgcagcgca gaagaccccg agaggctcgc 360 gaattacgcg agaaaacttg catcagccgc tggaaaggtg acagataaaa acatctccgg 420 aaaaattaat gatctacaag ctgtgatggc cgtaccgaat atggaaacat ccacattctg 480 cctacacact gatgctacat gcaagcaaag aggagacgtc gccatttatc aagacgtcta 540 cgccgtccat gcacctacct cgctgtacca ccaggcgatc aaaggagtcc acgtggcata 600 ttggataggg ttcgatacga cacctttcat gtacaatgca atggctggcg catacccatc 660 atattcaaca aactgggctg atgagcaggt actgaaggct aagaatatag ggctgtgttc 720 aacagaccta tctgagggta gacgaggcaa attatccatc atgagaggca aaaaatttaa 780 gccatgcgac cgagtgctat tctcggtcgg ctcaacactc taccctgaaa gtcgcaaact 840 tctacaaagc tggcatttac catcggtatt tcacctgaag ggtaaactca gcttcacctg 900 ccgctgtgac acaatcgtct catgcgaagg atacgtcgtc aagagagtga caatgagtcc 960 aggcatctac ggaaagacat cagggtatgc tgtaactcat catgccgacg gcttcctgat 1020 gtgcaagacg acagatacag tagacggtga aagggtatca ttctccgtgt gtacttacgt 1080 accagctact atctgcgatc agatgactgg aatccttgcc actgaggtaa ccccagaaga 1140 cgcacagaaa ctactggttg ggctaaacca acggatagtg gtcaatggca ggacgcaacg 1200 caatacaaac accatgaaaa attacctgct cccaatagtt gctcaggcct tcagcaagtg 1260 ggccaaagaa tgtcgaaagg acatggagga cgaaaagctc ttgggtgtcc gagagaggac 1320 cttaacgtgc tgttgcctgt gggcattcag aaagcacaag acgcatacgg tgtacaaaag 1380 accggatacc cagtcaatcc aaaaggtccc tgctgaattt gacagcttcg tgataccaag 1440 tctgtggtcg tcaggtttat caattccgct gagaaccaga atcaagtggc tcttgagcaa 1500 agctccaaaa cacgagcaac taccacacag cggaaacgca gaggaagcag ctcaggctga 1560 aacggatgcg gtggaagaac gggaggctga gctaacccga gaagctatgc caccattgca 1620 agcgacacag gatgacgttc aggtagaaat tgatgtagag caacttgaag accgagcagg 1680 agcgggcata gtcgaaacac caaggggagc aatcaaagtc acagcccaac cgtcagacct 1740 tgttgtcgga gagtacttag tactgacacc gcaggcggtc ctgcgcagcc aaaaactcgg 1800 tctgattcat gcgcttgcag agcaggtaaa aacgtgcaca catagtgggc gagcaggcag 1860 gtacgcggtt gaagcatacg acgggcgtgt tctagtgccc tcgggctacg cgatacccca 1920 ggaagatttc cagagcttaa gcgaaagcgc cactatggta tttaatgagc gagagtttgt 1980 gaaccggaag ttgcaccaca tcgccatgca cggcccagcg ctgaacaccg atgaagagtc 2040 atacgaactg gtaagggttg agaaaacaga acacgagtac gtctatgacg ttgatcagaa 2100 gaaatgctgc aagagagagg aagcaacagg actagtgcta gtaggcgact taactagccc 2160 accataccat gagttcgcct acgaaggact aaaaatccgc ccagcatgtc catacaaaac 2220 ggcagttata ggtgtcttcg gagtaccggg ttctggcaag tcggctataa tcaaaaatct 2280 ggtaaccagg caagacttgg tgaccagtgg caaaaaagaa aactgccaag aaatctccaa 2340 tgatgtaatg cggcaaagga aattggagat atctgcacgt acagtcgact cactactcct 2400 gaatggatgt aacaagccag tggaagtact gtacgtggat gaggcatttg cttgtcattc 2460 gggaaccctg ttggcactaa tagccatggt tagaccgcgt cagaaggtcg tactctgtgg 2520 cgacccaaag cagtgcggat tcttcaatat gatgcaaatg aaggttaact ataatcacaa 2580 catctgcaca caggtgtatc ataaaagcat atcaaggcgg tgtacactgc ctgtaacagc 2640 catcgtgtcc tcgttgcatt acgagagcaa gatgcgtact acaaatgagt acaaccagcc 2700 aatcgtagtg gatactacgg gcacaacaaa accagaaccc ggggacttag tgttaacgtg 2760 tttccgggga tgggttaagc agttgcaaat agactaccgt ggaaacgaag tcatgacagc 2820 agctgcttct caggggctga ctagaaaagg tgtttatgca gtaaggcaga aagtcaacga 2880 aaaccctctg tatgcatcaa cttcagaaca cgttaacgtg ttattgacac gcacagaggg 2940 caagttgata tggaaaacac tctcaggcga cccatggata aagatactgc agaacccccc 3000 aaaagggaac tttaaggcaa caatcaagga gtgggaagca gaacacgcct ccatcatggc 3060 aggaatatgc aattaccaga tggcttttga cacatttcag aacaaagcta atgtatgctg 3120 ggctaaatgc ctggtcccta ttcttgacac tgctggaatc aaactaagtg acaggcagtg 3180 gtctcagata gtgcaagctt ttaaagaaga tagggcctac tctccagaag ttgcactgaa 3240 tgaaatatgt acccgcatat atggggtaga tctggacagc ggactatttt caaagccgct 3300 gatatccgtc tactatgcag acaaccactg ggacaataga ccaggaggaa aaatgttcgg 3360 gttcaaccct gaggtggcac ttatgcttga aaagaaatac ccctttacaa aaggtaagtg 3420 gaacatcaac aagcagatat gtataactac cagaaaggtt gacgaattta accccgaaac 3480 caacataata ccggccaacc gaagactgcc gcactcactc gtggctgaac accactcagt 3540 gagaggggaa agaatggaat ggctggtaaa caaaatcaac ggtcaccaca tgttgttggt 3600 tagtggttat aatcttatat taccaacaaa aagagtcacc tgggtagcac cgttaggcac 3660 cagaggtgca gactacacat ataacctgga acttggtcta ccagccacac taggcagata 3720 tgacctggta gttatcaata tccatactcc attccgcata catcattacc agcagtgtgt 3780 agatcacgca atgaagctcc agatgctagg gggggactct ctacggctgt taaagccggg 3840 aggttcactt ctgattagag cttacgggta cgccgaccga accagtgaaa gggtcattag 3900 cgtattggga cgcaagttca gatcgtccag ggctctaaaa cctcagtgca tcacgagcaa 3960 tacagaaatg ttcttcctat ttagccgatt cgacaacgga agaaggaact tcaccacaca 4020 tgttatgaac aaccagctga atgcagtgta tgcaggactg gccactagag cgggctgtgc 4080 tccgtcatac cgtgtgaaac ggatggacat cgcgaaaaac actgaggaat gcgtggtaaa 4140 cgccgccaat ccacgcggag taccaggcga tggagtatgt aaagccgtgt atagaaaatg 4200 gccagagtca ttcagaaaca gtgcaacacc agtggggact gcaaagacaa tcatgtgcgg 4260 ccaatacccc gtcatccacg cagtaggtcc taacttctca aactattctg aggctgaagg 4320 ggatagggaa ttggcttcag cgtatagaga agtggcgaaa gaagtgtcta ggctaggagt 4380 gagcagtgta gccatccctt tgctttcaac cggtgtgtac tcaggaggca aagacagatt 4440 gctgcaatca ctaaaccatc ttttcgcagc gatggattcg acagatgcag atgttgtcat 4500 ctattgcagg gacaaggaat gggagaagaa gatcactgaa gccatatcac taagatccca 4560 ggtagaacta ctagatgatc acatctcagt ggattgcgac attgtacgcg ttcatccaga 4620 cagcagcctg gcaggccgaa aggggtacag cacagtagag ggagcactct actcttacct 4680 agagggaaca agattccacc aaactgctgt agatatggct gagatatata ccatgtggcc 4740 aaaacaaact gaagccaacg aacaggtctg cctatatgct ctgggggaga gtatagagtc 4800 cgtcaggcaa aaatgtcccg tagacgacgc cgacgcctca ttccctccga aaacagtccc 4860 gtgcctatgc cgttatgcca tgacgcctga acgagttgca cgcctacgca tgaatcatac 4920 tactagcatc atagtgtgct cgtcttttcc gctgccgaag tacaaaatcg agggcgtgca 4980 aaaagtaaaa tgttcaaaag cactcttgtt tgatcacaac gtaccgtctc gagtgagccc 5040 gagaacgtac aggcctgcgg acgaaatcat acagacacct caaatatcaa ctgaagcgtg 5100 tcaggacgca caactcgtgc agtcaataaa tgatgaagca gtgccagttc cctcggactt 5160 agaggcttgt gacgcaacta tggactggcc ctctatcggc accgtaccaa caagacaaag 5220 acacgactca tttgacagcg agtatagttc cagaagcaac atacagctag tgacggcgga 5280 cgtgcatgca ccaatgtacg caaattcgct ggcgtccagc ggaggttcaa tgctgtcgct 5340 gtccagtgaa ccagctcaga acggcataat gatactacct gactcagaag acacagatag 5400 tataagcaga gtaagcacac cgatcgcccc gcccaggaga cgtttgggaa ggaccataaa 5460 tgttacttgt gacgagcggg aagggaaaat actccctatg gccagcgaca ggttcttcac 5520 tgctaagcca tacactgtcg cactgagcgt atcaacagca gacataactg cgtaccccat 5580 ccaggcaccg ctaggattga cacaaccacc taccctcgaa cagatcactt tcggagattt 5640 tgccgaaggt gaaatagaca acctcctgac aggggcattg acatttgggg acttcgagcc 5700 aggtgaagtg gaagagctga cggatagcga gtggtcaaca tgctcggaca cagatgaaga 5760 gttacgacta gacagagcag ggggttacat attctcctct gacactggcc aaggtcatct 5820 acagcaaaaa tcagtacgtc aaacgacgct accagtaaac attgttgaag aggtccacga 5880 agagaaatgc tatccaccta aattggatga gaccaaagag caactcctac ttaagagact 5940 ccaggagagt gcttccacgg ctaaccggag taggtaccaa tctagaaaag tggaaaacat 6000 gaaagccacg attatccaca gactgaaaga gggttgcagg ctctacttgg cgtcagatac 6060 accgagggtc ccatcttacc gaatcacata cccggcgcct gtctactcgc cttcaatcaa 6120 tatcaaattg agtaacccag agactgcagt agcagtgtgt aacgagtttt tggccagaaa 6180 ctatccaact gtggcatcct accaagttac tgacgagtac gacgcgtact tggatatggt 6240 agacgggtct gaaagctgcc tagacagagc tacatttaac ccgtctaaac tcaggagtta 6300 cccaaaacaa cactcttacc acgcgcccac catcagaagt gcagtgccat caccattcca 6360 aaatacgttg cagaatgtct tggcagcggc cacaaaaaga aactgcaacg taacgcagat 6420 gagggaattg cccactatgg actccgcagt gtttaacgtg gagtgtttta agaagtacgc 6480 atgcaaccaa gagtactgga gagagttcgc ctcaagccct ataagggtaa cgacagagaa 6540 tctgacaatg tatgtgacga aactaaaggg gcctaaagcg gcggcactct tcgcaaaaac 6600 acacaacttg ctgccgctac aagaggtacc aatggacagg ttcacaatgg acatgaaacg 6660 tgatgtaaaa gtgacaccag gtacaaagca caccgaggaa aggccgaaag tacaggtcat 6720 acaggcggca gaaccgctgg caacagcata tctgtgtggc atacacagag agttggtaag 6780 aagactaaat gcagttctgc taccgaatgt ccacacactg ttcgatatgt cagccgaaga 6840 cttcgatgca atcatagcca cacatttcaa accgggcgat gctgtactag aaaccgacat 6900 agcctcattt gacaagagtc aagacgactc gcttgcgctg accgccatga tgctgctaga 6960 agatcttggg gtagaccaac ctatcctgga tctgatagaa gcagcattcg gcgaaatatc 7020 cagttgccat ctaccgacgg gcacgcggtt taagttcggc gcaatgatga aatcaggcat 7080 gtttctaacc ctgtttgtca ataccctcct gaatatcacc attgctagtc gggtgttgga 7140 ggagagattg actacttcag cctgtgcagc tttcattggg gacgacaaca taatacatgg 7200 agttgtctct gacgcactaa tggctgcacg ttgtgctacg tggatgaaca tggaagtgaa 7260 aatcatcgat gcagtagtgt cagagaaggc gccatacttc tgcgggggat ttattttaca 7320 cgacacggtg acaggcacgt cgtgtagagt agcagaccct ttaaagagac tgttcaagtt 7380 aggcaaacct ctggcagctg gagacgaaca ggatgaggac agaagacgtg ctctggcaga 7440 tgaggttact agatggcaaa gaaccggctt agtcacagaa ctggaaaaag cagtatactc 7500 aaggtatgaa gtacaaggaa taacagccgt aataacatca atggctacct ttgcgagtag 7560 taaagaaaac tttaaaaaac taagagggcc cgtcgtaacc ttgtacggcg gacctaaata 7620 ggtacgcatt acagctacct actttgagac aaacaccgct aatagccatg gagttcatac 7680 cagcacaaac ttactataat agaagatacc agcctagacc ttggacccaa cgccctacta 7740 tccaggtgat caggccaaaa ccacgccgga gaagacctgc aggacaactc gcacaactga 7800 tatccgcagt cagcagacta gcactgcgta cagttcccca gaaaccacgc cggacccgaa 7860 aaattaagaa gcaaaaacaa gtaaagcaag aacaacagag cactaggaac cagaagaaaa 7920 aggcgccgaa acaaaagcag actcaaaaga aaaagagacc aggacgcagg gaaaggatgt 7980 gcatgaagat tgaaaatgac tgcatcttcg aagtcaaaca tgaaggaaaa gtaacggggt 8040 atgcatgcct agtaggtgat aaggtaatga aaccagcaca tgtgaaaggg actattgaca 8100 acgcagacct agcgaagttg gcgttcaaaa gatcatccaa atatgatcta gaatgcgcac 8160 agataccagt gcacatgaaa tcggacgcct caaagttcac ccatgaaaaa ccagaaggct 8220 actacaactg gcatcacgga gcggtacagt attctggagg gaggttcaca atccctacag 8280 gcgcgggaaa gcctggggac agcggaagac caatctttga caacaagggg cgcgtcgtgg 8340 ctattgttct aggcggggca aacgaaggaa ccaggacagc actatctgta gtgacttgga 8400 ataaagacat agtcacaaaa atcacaccgg aggggtcagt tgaatggagc cttgccctcc 8460 ctgtcatgtg cctgttggca aacacaacct tcccatgttc ccaaccgcct tgcgcgccgt 8520 gctgctacga aaagaaaccg gaagaaacct tgaggatgct ggaggacaac gtcatgcaac 8580 cagggtacta ccagttactc gattcagcat tggcctgctc acaacatcgt caaagacgta 8640 atgcaagaga aaacttcaat gtctacaaag tcactaggcc gtacttagcc cactgccctg 8700 actgcgggga gggacattca tgtcacagcc caatagcatt agaacggatc agaagtgagg 8760 caacagatgg taccttgaaa atccaggtat ctctgcaaat cggaataaag acagccgaca 8820 gccacgattg gacgaagctg cggtatatgg atagccatac acctgtggat gcagaccgat 8880 ctggtttgtt cgtcagaacg tcagcaccgt gcaccatcac gggaacgatg ggacatttca 8940 tactagcacg ctgtccgaaa ggagagacgc tgacggtagg atttgtagac agtagaagga 9000 tcagtcacac atgcatgcac ccgttccacc acgagccgcc gctgataggg agagagaagt 9060 ttcactcccg cccacagcat ggcaaagaac taccttgcag tacgtacgtc cataccacag 9120 cggccactac tgaggaaata gaagtgcata tgccgccaga tacccctgac tacacgctaa 9180 tgacacagca agcgggaaat gttaagatca cagttgacgg ccagacggta cgatacaagt 9240 gcaaatgtga cggctccaat gaaggattaa taaccactga caaagtcata aataactgca 9300 aagtagacca atgccacaca gcagttacaa accacaagaa atggcaatac aactcaccgt 9360 tgaccccgcg gaactccgaa caaggagata gaaaaggtaa aatccatatc ccatttccat 9420 tggtgaacac aacctgcagg gtaccaaaag caagaaatcc gactgtcaca tacggtaaaa 9480 acagagtcac tctgctgttg tatccagacc atccaacact cctttcgtat cgcgccatgg 9540 gaaggatccc ggattaccat gaagagtgga taacaagcaa gaaggaaata agtattacag 9600 taccagcaga aggtttagag gtcacgtggg gtaataatga cccatataaa tattggccgc 9660 aactgtctac aaatggtact gcgcacgggc acccacacga aataatcctc tattactatg 9720 agctgtaccc aactaccaca attgctgtac tagctgctgc ttctatcgta gtagcatctt 9780 tggtaggtct atcattaggc atgtgcatat gcgcgagacg caggtgcatc acgccgtatg 9840 agctaactcc aggagctacc atcccattcc tcctaggtat actatgctgt gtcaagactg 9900 caaaagcagc atcgtactac gaagctgcaa catacctctg gaatgagcaa caaccattat 9960 tttggttaca gcttttaatc cctctgtcag ctgcaattgt tgtgtgtaat tgcctaaaac 10020 ttttaccatg ctgctgcaaa acattgactt ttttagccgt catgagcatc ggtgcccgca 10080 ctgtgtccgc gtacgagcac gcaacagtga tcccgaacac ggtgggagta ccgtataaga 10140 ctcttgttag cagaccaggg tatagcccta tggtcttaga aatggagcta cagtcggtca 10200 ctctggaacc aacattgttc ttggattaca tcacgtgtga gtataaaaca atcacaccgt 10260 ccccgtacgt aaaatgctgt ggtacagctg aatgtaaggc caagaaccta ccagattata 10320 actgcaaagt attcacaggc gtctacccat ttatgtgggg aggagcatat tgcttctgtg 10380 acgcagagaa cacacaactc agtgaggcac acgttgagaa atcagaatca tgcaaaactg 10440 agtttgcatc agcctacaga gcccacacag cttcagtatc agctaaacta cgtgtctttt 10500 accaagggaa taatatcacc gtgtctgcat acgctaatgg tgatcatgca gtcacggtaa 10560 aagacgcgaa gtttgtcatc ggtccactat cgtccgcctg gtcaccattt gataataaga 10620 tcgtggtgta caaaggcgaa gtctacaaca tggactatcc acctttcggc gcagggaggc 10680 caggacagtt cggtgacatc cagagccgca cgccagacag caaggatgtc tatgcgaata 10740 cgcagttaat actgcaaaga ccagcggcag gagcaataca cgtgccttat tcccaggcac 10800 cttcgggctt taagtactgg ctcaaagaaa aaggggcatc attgcagcat acggcaccat 10860 ttggctgtca gatagcaaca aacccggtaa gagcagtgaa ctgtgcagtg ggcaacatac 10920 cagtctccat tgacatccca gatgcagctt tcaccagggt cactgacgct ccttccgtca 10980 cagacatgtc ctgtgaagtg gcttcgtgta cccattcatc tgattttgga ggtgccgcag 11040 tcataaagta cacagctagt aaaaagggga aatgcgctgt gcactcttta acaaacgcgg 11100 tcactatccg cgaacctaac gtagatgtcg agggaacagc acaattacag attgccttct 11160 cgaccgcact agctagtgcg gaatttaagg tgcagatctg ctccacacag gtacactgct 11220 cagcgacgtg ccatcctcct aaagatcaca tagtcaacta cccgtcaccg cacaccacac 11280 taggagtgca ggacatctca acgacagcta tgtcttgggt ccagaagatt acaggaggag 11340 tgggactcgt ggttgctata gctgctttga tcttaattat agttctctgc gtatcattta 11400 gcagacacta aagtatacat gccccaaagt aatatactat acaggtatac gtgctccctg 11460 agcagcacaa catatgtatt atctataaaa gaaaaacaaa aatataaaaa ttataaaata 11520 caaaagtata aaaacaggta tcagtacccc cttagaggta catcacttaa ccaggtatta 11580 gtgccccctt agaggcacat tatataacca ggtataggtg cccccttaga ggcacactaa 11640 caataggtat aagtgccccc ttagtggcac actaaccacc acaattggta atatgaagag 11700 acgtaggtat gaagcttcat aaaagctgcc gaacttactt taagatgtag gcgtaccgaa 11760 ctcttcaaca attctccgaa cccgcaggga cgtaggagaa gttattttgt ttttaatatt 11820 c 11821 //