ID FJ555055; SV 1; linear; genomic RNA; STD; VRL; 6580 BP. XX AC FJ555055; XX DT 27-JAN-2009 (Rel. 99, Created) DT 27-JAN-2009 (Rel. 99, Last updated, Version 1) XX DE Human cosavirus E1 polyprotein gene, complete cds. XX KW . XX OS cosavirus E1 OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Picornavirales; Picornaviridae; Caphthovirinae; Cosavirus; Cosavirus E. XX RN [1] RC Publication Status: Online-Only RP 1-6580 RX PUBMED; 19102772. RA Holtz L.R., Finkbeiner S.R., Kirkwood C.D., Wang D.; RT "Identification of a novel picornavirus related to cosaviruses in a child RT with acute diarrhea"; RL Virol J 5:159-159(2008). XX RN [2] RP 1-6580 RA Holtz L.R., Finkbeiner S.R., Kirkwood C.D., Wang D.; RT ; RL Submitted (16-DEC-2008) to the INSDC. RL Molecular Microbiology and Pathology and Immunology, Washington University RL School of Medicine, 660 S. Euclid Ave, Campus Box 8230, St. Louis, MO RL 63110, USA XX DR MD5; 270978e66919fd07886dcdd54127fad5. DR EuropePMC; PMC2615758; 19102772. DR EuropePMC; PMC2706813; 19552824. DR EuropePMC; PMC3810744; 24047954. DR EuropePMC; PMC6098101; 30120342. XX FH Key Location/Qualifiers FH FT source 1..6580 FT /organism="cosavirus E1" FT /host="Homo sapiens" FT /mol_type="genomic RNA" FT /country="Australia" FT /collection_date="1981" FT /db_xref="taxon:2849712" FT 5'UTR <1..138 FT CDS 139..6480 FT /codon_start=1 FT /product="polyprotein" FT /db_xref="GOA:B9VIN1" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR004004" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="InterPro:IPR037080" FT /db_xref="UniProtKB/TrEMBL:B9VIN1" FT /protein_id="ACL99815.1" FT /translation="MGANNSKESVSSNGNQGTIVNNFYANQYYGSVDASAQGVGSDTTP FT ENGTVSGFLGLAASAFNAAGFLATPSAENSTNMGDRILTLREGNTAISSQATEGILHGY FT NKETDTSQPTSCGDRASKATPATQRSFIIPLKDWTSSQNSYSALVYRTSHMSKDAVGNL FT FSKNMNTHAYTKTGWTATLQINTSPFHSGLIGLFMVPEFVRKISDDLEWIDLVAAGFNT FT TLFKDSNTYNQDSALVGKIDDKNTFDLASTTPEQFFLYPHQLINPKETTMATVSVPYVN FT VAPSSDPSVHNIWTVVVMVLSPLQIGSGASPNVQMTLTLTPTGSVFNGLRHPKPAAQSP FT FPTRPFHHSFQFSSTVPDVTEPCYGMTVVPPKDFMPAPITDLVSLAKVPTFCTVTENKP FT YFEVNNNKSDAPVFQSNVVLSDPHYAHTLVAGLGRYFGNYRGSLQFTLISATTSMTRGK FT LLCCYTPPGADKPTTVEQAMMSTYAIWDLGLQSTFEFVVPFISTVDFRVNVVSTSSAVN FT VDGWFSIFKLNALTYPANTPPNQHILVMLSGGSDFSYRLPIAPPFNLHSPDPEPHDNAE FT KGTSSNHDASLTGGHSVGIKVAHSDTSFFFDRYRYIGTVESTKNTPATVATLTDTNGII FT KSFNNLANADNGYKKVLMLAPNPSFCGAAYTVFAMFDQTGTTGAKKRLLFGQGDYHLYR FT SCPFTYYTADLEVTVVPDAGVAGPWRVTWLPVGAPLDEIEMITSETSNPQSWSFFTEDR FT KDSSSLYSLNPTFWSNDQNKVSFDIPMTTPLTLLPLYFDGYPDYSNTKGLYGVAPANGF FT GNIVVKSNTLADKFMVYIRYKNFRGYVPRPLPRLVQPNPSSRVRMAASDGLAPRKYLSY FT RKIQLSGDVETNPGPNFSKFCVQGPTSDFIRLVRDPETLDNVNRLLSTLNNLMAKWNSF FT KHMCLDSYFLRDILCLLTKLTALGFLVHNQGPSAYLAAAAILISDGISFLDWYDKIKRF FT MSRRLRISPPPFCLAQGLDLRDVVTFFNAAKGAQWMVDSIRSLIRWIKQWLELEEENEA FT VQFEKMLVDSPKHCKAINDYNVGKTFVRPENSFDFMDKLVDSATKLGRVNIASYFRSFT FT SVDTDAPRMEPVVLVLRGKPGAGKSAAATVIAAAVSKTLTGTQSVYTLSPDTEHMDGYH FT GQFSMIMDDLGQNPDGEDFRTFCQMISCAQYRPSMADLRDKGILFKSQFIIATTNLPEF FT RPLTISDRGAVERRITFDIGVTPGSAATRNGKLDLAIALKPDGPGEFPYNCDCQLLHTT FT GLALQNLRSGKTMNLKELVDMIVKKIKSKRTTSGMLEGLVMQSPKIVGYTKDDEGVVIV FT DCLEEWNKIKDKKRKQQALEMVAEEIKVQHEKHRETVNLLKMFLSGLGVVAAVGAALAA FT GAYLKSETAGKAVDEPDTKKEEETKTEGPYNGPSKKDLKTLKLKAQSPLLDLEKKIMNN FT VQPFVMRFGNREYVQSCLFVGKRVFLVNKHAIETVEERFSVAGTEYNIDDVEIAILDTE FT YGLTDVAAVKISNGPEWKNLSKLFLNLETELLPGTRITVLSNDNINMLREGSFLRYEEE FT IPTNIGPIPFVMLYKASSYFGMCGSAVVTRFGDSSGILGIHCAGGGGVSVASRVTRKMV FT ETVLEYFYPPQVQGLIIKEEIGERVHVPRQSKLKRTHATYPATKDYGPAVLSKNDPRLN FT PGVDFDSVIFSKHVNNVVIDKDTSIWQSLKLAAQVYAQRLKNIDKEPLTVEEAIAGIPG FT LDRLDPKTASGLPYKKTRKQMIDFQKCEITDDQLKCRLGMWLAGRKPETLYQTFLKDEI FT RPIEKVKAGKTRIIDVTPLDHVLAFRIVMGRFMAGFHQNHGFKLGSAVGCDPDVAWANY FT GFKLGGFKYQYDFDYSNFDASHSESIFEVLKEFIFTPDNGFDQRCSLMIDSLVESVHCY FT EDKRITIRGGLPSGTAGTSIINTIINNIILHAAFYYTYSNFEWDDLQMLAYGDDIVAAS FT DHELDLDRIKDFMARIGYKITPADKGETFTPKSMKDIQFLKRRFRKIAGIWAPVMEISN FT LQAMLSWYKPGTLNEKLESVSRLAHFCGEEEYNELFKPFVEDGFDIKPWKQLHLEWLNK FT FTG" FT mat_peptide 139..342 FT /product="VP4" FT mat_peptide 343..1152 FT /product="VP2" FT mat_peptide 1153..1848 FT /product="VP3" FT mat_peptide 1849..2682 FT /product="VP1" FT mat_peptide 2683..2793 FT /product="2A" FT mat_peptide 2794..3153 FT /product="2B" FT mat_peptide 3154..4116 FT /product="2C" FT mat_peptide 4117..4425 FT /product="3A" FT mat_peptide 4426..4482 FT /product="3B" FT mat_peptide 4483..5091 FT /product="3C" FT mat_peptide 5092..6477 FT /product="3D" FT 3'UTR 6481..6562 FT polyA_site 6562 XX SQ Sequence 6580 BP; 1966 A; 1409 C; 1350 G; 1855 T; 0 other; ctttgctcac tcagcacagg atctgatcag gagatttgtc tccggtgctt tacaccggag 60 cacaaattta aaaattgccc aaggcctggc aaataaccta ggggactagg ttttctttta 120 atttacacgt ctgtcaatat gggtgcaaac aatagcaagg agtctgtgtc aagcaatggc 180 aatcaaggga ctattgttaa taacttttat gctaaccagt attatggctc tgttgatgct 240 tctgcccagg gggtcggtag cgatactact cctgaaaatg gtactgtctc tggctttctt 300 ggacttgcag cttctgcttt taatgcggcc ggatttcttg caaccccgag cgcagaaaac 360 tctacgaaca tgggtgatag aattctgaca ctgcgtgaag gcaatacggc aattagctca 420 caggcaactg aaggcatttt gcatggttac aacaaggaga ctgatacctc ccaaccaaca 480 tcttgcggtg atcgtgcaag caaggcgaca ccagcaacac aaagaagctt cataataccc 540 ctcaaagatt ggacatcaag tcaaaattca tacagtgcac ttgtctacag aacatcacac 600 atgtcaaaag acgcagtagg taatctgttt tccaaaaaca tgaacacaca tgcatacacc 660 aaaacaggat ggactgcaac cttacagatt aacacatctc cctttcattc aggtttgatt 720 ggtttgttca tggttccaga atttgttagg aaaatcagtg atgatctgga atggattgat 780 cttgttgctg caggcttcaa tacaactcta ttcaaggact caaacaccta caaccaggac 840 tctgctttag ttggaaaaat agatgacaaa aacacatttg acctggcttc cacaacccca 900 gagcaattct ttttatatcc acaccaacta ataaacccaa aagaaacaac tatggcaaca 960 gttagtgttc cctatgtaaa tgtggctccc agctcagacc cttctgtaca taatatttgg 1020 actgtggtgg taatggttct ctcacctttg caaataggca gtggtgcatc tcccaatgta 1080 caaatgactc tcacgcttac tccaactgga tctgttttca atggcttgag acatcccaaa 1140 ccagctgccc aatcaccctt tcctactaga ccctttcatc actcatttca gtttagttca 1200 actgtgccag atgtgactga accctgttat ggtatgactg ttgttccacc caaagacttc 1260 atgccagccc caataacaga tttggtttct cttgcgaagg tgccaacctt ttgcacagtt 1320 accgaaaaca agccatattt cgaggtcaac aataataaat cagatgcccc cgtttttcag 1380 tctaacgtgg ttctttctga ccctcactat gcccacaccc tagttgcagg tttgggtcgt 1440 tactttggaa attacagagg tagtttacaa ttcactttga tctcagctac aacaagcatg 1500 acccgtggaa aactgctgtg ttgttacacc cctccaggtg ctgacaaacc aaccactgtt 1560 gaacaagcaa tgatgtctac ttatgctata tgggatttag gacttcagtc cacctttgaa 1620 tttgttgtgc ctttcatatc tactgttgac tttagagtaa atgttgtctc tacttcctca 1680 gccgtcaacg tagatggttg gttttcaatt ttcaaactaa atgctctaac ctacccagca 1740 aatacccccc caaaccaaca catactagta atgctatcag gtgggtcgga tttttcttac 1800 cgcctcccaa ttgccccccc cttcaacctg cactctccag acccagaacc ccatgacaat 1860 gcagaaaaag gtactagcag taaccatgat gcttctctaa ctggaggaca cagtgttggt 1920 attaaagttg cccattcgga tacctctttt ttctttgaca gatacagata tattggaact 1980 gttgaatcaa caaagaacac tcctgctacg gtggctactt taacagatac aaatggaatc 2040 ataaaatctt ttaacaattt ggcaaatgca gataacggtt acaagaaagt tttgatgctt 2100 gcccctaatc cctctttctg tggtgctgcc tataccgttt ttgctatgtt tgaccagaca 2160 ggaacaacag gtgcgaagaa aagacttttg tttggtcagg gtgattatca tctttacaga 2220 tcttgtccct tcacttacta tactgcagat ctggaagtaa cagtggtgcc tgatgcaggc 2280 gttgctggtc cgtggcgtgt cacctggcta ccggttggcg ctccactaga tgagatagaa 2340 atgattacca gtgagacttc caatccccag tcttggtctt tctttactga agatagaaaa 2400 gattcctcat ccttgtattc tctaaaccca actttttggt ccaacgacca aaacaaggta 2460 tcttttgaca ttccaatgac aactcctcta acgcttcttc ctttgtattt tgatggttat 2520 ccagactatt caaacacaaa aggtttgtac ggtgttgccc cagctaatgg atttggaaat 2580 attgtggtaa agagtaacac tttggctgac aaatttatgg tctatattag atacaaaaat 2640 ttcagaggtt atgtgcccag acctttaccc cgtcttgttc aaccaaaccc gagttcacgc 2700 gtcaggatgg ctgcttcaga tggtttagcc cctagaaagt acttatccta tagaaaaata 2760 cagctttcag gtgatgtaga aacaaacccg ggccctaact tttcaaagtt ttgtgtccaa 2820 ggtccaacat cggactttat taggcttgtt agagacccag aaacacttga taatgtaaat 2880 aggcttcttt ctactttaaa caatttaatg gccaaatgga attcttttaa acatatgtgc 2940 ttagactctt acttcttgag agatatcttg tgtcttctaa ccaagttgac tgcacttgga 3000 tttcttgttc acaaccaggg accttcagca tatcttgctg ctgctgctat actcatttca 3060 gatggcatat cgtttttgga ctggtatgac aaaataaaaa gattcatgtc gagaagacta 3120 agaatttctc cccccccctt ttgtcttgct caaggtcttg acctcagaga tgttgtgaca 3180 tttttcaatg ccgcaaaggg tgctcagtgg atggttgact ctattcggag tttgataaga 3240 tggattaaac agtggcttga gctcgaagaa gagaatgaag ctgttcagtt tgagaagatg 3300 cttgtggata gtcccaaaca ctgtaaggca ataaatgact acaatgttgg aaagactttt 3360 gtgagaccag aaaactcctt tgactttatg gacaagcttg tcgactcagc aacaaagctc 3420 ggtagggtga acattgcttc atacttccgt tctttcacct cagttgacac agatgccccc 3480 agaatggaac ctgttgtttt ggtgcttcgc gggaaacccg gagcgggaaa atcagcagca 3540 gctactgtta tcgctgcagc agtttcaaaa actctcacag gaacccaatc agtatacaca 3600 ctctctccag acactgaaca catggatgga taccacggac aattttccat gataatggat 3660 gaccttggac agaacccgga cggtgaggat ttcagaactt tttgccaaat gatttcatgt 3720 gcccagtatc gaccatctat ggccgatttg agagacaaag gaattctttt taaatcgcaa 3780 ttcatcattg caacaacaaa tttaccagaa tttagaccac ttacaatttc tgatcgtggt 3840 gcagttgaaa gacgcatcac ttttgacatt ggagtaaccc ccggttcagc agcaacccga 3900 aacggtaagc tggaccttgc tatcgccctg aagccagatg gacccggtga atttccttac 3960 aactgtgact gtcagctttt acacacaact ggacttgcac ttcagaattt gagatcaggg 4020 aaaacaatga acctcaaaga attagtagac atgattgtga aaaagataaa gtcaaaaagg 4080 accaccagtg gcatgcttga aggattagtc atgcagtctc caaagattgt tggctacacc 4140 aaagatgacg aaggtgtcgt cattgttgac tgtcttgagg aatggaacaa aatcaaagac 4200 aagaagagga aacaacaagc attggaaatg gtagcagaag aaataaaagt acaacatgaa 4260 aaacacaggg aaacagttaa tcttctaaaa atgttcttat caggtcttgg tgtagtagcc 4320 gctgttggtg cagcactagc agctggagct tacctaaaat cagaaactgc tggtaaagct 4380 gtggatgaac cagatacaaa gaaggaagaa gaaactaaaa cagaaggccc ttacaatgga 4440 ccatcaaaga aggatctgaa aactctaaag ctaaaagccc agagcccttt gttggatctt 4500 gagaagaaga taatgaataa tgttcagccc tttgtaatga gatttggaaa cagagagtat 4560 gtgcaatcat gtctttttgt ggggaaaaga gtttttcttg tgaacaaaca cgcaattgag 4620 accgttgaag aacgattctc ggttgcaggc actgaatata acattgatga tgtggaaatt 4680 gctattcttg acacagagta cggcttgaca gatgttgcag ccgttaagat aagcaatggc 4740 ccggagtgga aaaacctttc aaaactcttt ctgaaccttg aaactgaact cttgcccgga 4800 acgaggatta cggttttgtc taacgacaac atcaacatgt taagagaagg ttcttttctt 4860 cgttatgaag aagagatacc tacaaacatc ggcccaatcc cctttgttat gctatacaag 4920 gcatcctcat actttggcat gtgtggatcc gctgtggtta ccagatttgg agacagttct 4980 ggtatcttag gcatccattg tgctggtggt ggcggtgtta gtgtggctag cagagtaacc 5040 aggaaaatgg ttgaaacagt tttggaatac ttttatcccc ctcaagtgca aggactaatc 5100 attaaggagg agataggaga gagagtgcat gtacctagac aatcaaaact aaagagaact 5160 catgcaactt acccagcaac caaagattac ggccctgctg tgctttccaa aaatgaccct 5220 agactaaacc caggtgttga ttttgattca gtcattttct ctaaacacgt gaataacgtg 5280 gtaattgata aagacacttc aatttggcag tctttgaagc tcgctgccca ggtttatgct 5340 caaaggttaa agaatattga caaagagcct cttacagttg aagaggcaat tgctggaatt 5400 cctggacttg accgcttgga ccccaaaact gcttcaggtt tgccctacaa aaagacaagg 5460 aaacagatga ttgactttca aaaatgtgag atcactgatg accaacttaa gtgtagactt 5520 ggaatgtggc ttgcaggcag aaaaccagaa actctttatc aaacattttt aaaagatgaa 5580 attagaccca ttgaaaaagt aaaggctgga aaaaccagaa taattgatgt gaccccgttg 5640 gatcatgtct tggctttcag aattgtaatg ggaaggttta tggcaggttt ccaccagaac 5700 cacggcttca aacttggctc agctgtcgga tgtgaccctg atgtggcgtg ggcgaactat 5760 ggatttaaat taggtggctt caaatatcag tatgactttg actactctaa ctttgatgct 5820 tctcactctg aatccatctt tgaagttctt aaagaattca tctttacccc agacaacggt 5880 tttgatcaac gttgctctct catgatcgat tcacttgttg aatcggttca ttgctatgag 5940 gacaagcgca tcaccatacg tggtgggctg ccttcaggca ctgctggaac ttcaataatc 6000 aacactatca ttaataacat aatcttgcac gctgctttct attataccta ctctaacttt 6060 gaatgggatg atttacagat gcttgcttat ggtgatgaca ttgttgctgc ctcagaccat 6120 gaacttgatc ttgacagaat taaggatttt atggctagga ttggatacaa aataacacca 6180 gctgataagg gagagacttt caccccaaag agcatgaagg acattcagtt cttaaaacgc 6240 cgctttcgaa agattgccgg catttgggct ccagttatgg aaatttcaaa tttacaggct 6300 atgctttctt ggtataaacc tggaacactg aatgaaaaac tggaaagtgt gtcccgcctc 6360 gcccactttt gtggagagga ggaatacaat gaattgttca agccgtttgt tgaggacggc 6420 tttgacataa agccctggaa acagctccac ttggagtggc tcaataaatt tacaggttaa 6480 atagattttc aattcgactt cagttttaat ttggtttaac ttggctaatt aggacactta 6540 ttgggtattt caaattttga tcaaaaaaaa aaaaaaaaaa 6580 //