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Bindschadler2001_coupled_Ca_oscillators
View the 2007-04 Model of the Month entry for this model
Model Identifier
BIOMD0000000058
Short description
The model reproduces the same amplitude antiphase calcium oscillations of coupled cells depicted in Figure 5B of the publication. This model was successfully tested on Jarnac and MathSBML. The values of "h1" and "h2" are not given in the publication, but the antiphase oscillations are reproduced over a narrow range of values of h1, h2,c1,c2,D and p. The values of D and p are given, while the other values were plugged in, in order to simulate the time profiles shown in the Figure.
Format
SBML
(L2V1)
Related Publication
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A bifurcation analysis of two coupled calcium oscillators.
- Michael Bindschadler, James Sneyd
- Chaos (Woodbury, N.Y.) , 3/ 2001 , Volume 11 , Issue 1 , pages: 237-246 , PubMed ID: 12779457
- Department of Mathematics, University of Michigan, Ann Arbor, Michigan.
- In many cell types, asynchronous or synchronous oscillations in the concentration of intracellular free calcium occur in adjacent cells that are coupled by gap junctions. Such oscillations are believed to underlie oscillatory intercellular calcium waves in some cell types, and thus it is important to understand how they occur and are modified by intercellular coupling. Using a previous model of intracellular calcium oscillations in pancreatic acinar cells, this article explores the effects of coupling two cells with a simple linear diffusion term. Depending on the concentration of a signal molecule, inositol (1,4,5)-trisphosphate, coupling two identical cells by diffusion can give rise to synchronized in-phase oscillations, as well as different-amplitude in-phase oscillations and same-amplitude antiphase oscillations. Coupling two nonidentical cells leads to more complex behaviors such as cascades of period doubling and multiply periodic solutions. This study is a first step towards understanding the role and significance of the diffusion of calcium through gap junctions in the coordination of oscillatory calcium waves in a variety of cell types. (c) 2001 American Institute of Physics.
Contributors
Submitter of the first revision: Harish Dharuri
Submitter of this revision: Harish Dharuri
Curator: Lucian Smith
Modeller: Harish Dharuri
Submitter of this revision: Harish Dharuri
Curator: Lucian Smith
Modeller: Harish Dharuri
Metadata information
Curation status
Curated
Modelling approach(es)
Connected external resources
OmicsDI Impact Metrics
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Model files (1) |
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BIOMD0000000058.xml.origin | SBML L2V1 representation of Bindschadler2001_coupled_Ca_oscillators | 19.72 KB | Preview | Download |
- Model originally submitted by : Harish Dharuri
- Submitted: Jun 8, 2006 9:06:22 AM
- Last Modified: Aug 21, 2024 6:50:49 PM
Revisions
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Version: 3
- Submitted on: Aug 21, 2024 6:50:49 PM
- Submitted by: Lucian Smith
- With comment: CRBM-sponsored manual and automated updates.
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Version: 2
- Submitted on: May 24, 2014 5:17:03 PM
- Submitted by: Harish Dharuri
- With comment: Current version of Bindschadler2001_coupled_Ca_oscillators
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Version: 1
- Submitted on: Jun 8, 2006 9:06:22 AM
- Submitted by: Harish Dharuri
- With comment: Original import of Bindschadler2001_coupled_Ca_oscillators
(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions of this model will only be shown to the submitter and their collaborators.
Curator's comment:
(added: 18 Dec 2006, 22:50:25, updated: 18 Dec 2006, 22:50:25)
(added: 18 Dec 2006, 22:50:25, updated: 18 Dec 2006, 22:50:25)
Same amplitude antiphase calcium oscillations of coupled cells as depicted in Fig 5 b of the paper. Simulation result obtained from MathSBML.