Yamada2003_JAK_STAT_pathway

Model Identifier
BIOMD0000000093
Short description

NCBS Curation Comments This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in simulations.

Biomodels Curation Comments The model reproduces Fig 2 (A,C,E,G,I,K,M) of the paper. The set of equations present in the paper are inadequate to reproduce the figures mentioned . The model appears to have been fine tuned after correspondence between the curators at NCBS and the authors. There is however a slight discrepancy between the simulation results and the plots in the paper. The model was tested on MathSBML.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.
For more information see the terms of use .

Format
SBML (L2V1)
Related Publication
  • Control mechanism of JAK/STAT signal transduction pathway.
  • Satoshi Yamada, Satoru Shiono, Akiko Joo, Akihiko Yoshimura
  • FEBS letters , 1/ 2003 , Volume 534 , Issue 1-3 , pages: 190-196 , PubMed ID: 12527385
Contributors
Submitter of the first revision: Sharat Vayttaden
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Sharat Vayttaden

Metadata information

is (4 statements)
BioModels Database BIOMD0000000093
Gene Ontology JAK-STAT cascade
BioModels Database MODEL4879478021
KEGG Pathway Jak-STAT signaling pathway - Mus musculus (mouse)

isDescribedBy (1 statement)
PubMed 12527385

hasTaxon (1 statement)
Taxonomy Mus musculus

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources