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Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99)
View the 2015-05 Model of the Month entry for this model
Model Identifier
BIOMD0000000529
Short description
Format
SBML
(L2V4)
Related Publication
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Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.
- M Fribourg, B Hartmann, M Schmolke, N Marjanovic, R A Albrecht, A García-Sastre, S C Sealfon, C Jayaprakash, F Hayot
- Journal of theoretical biology , 6/ 2014 , Volume 351 , pages: 47-57 , PubMed ID: 24594370
- Department of Neurology and Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
- Viral antagonism of host responses is an essential component of virus pathogenicity. The study of the interplay between immune response and viral antagonism is challenging due to the involvement of many processes acting at multiple time scales. Here we develop an ordinary differential equation model to investigate the early, experimentally measured, responses of human monocyte-derived dendritic cells to infection by two H1N1 influenza A viruses of different clinical outcomes: pandemic A/California/4/2009 and seasonal A/New Caledonia/20/1999. Our results reveal how the strength of virus antagonism, and the time scale over which it acts to thwart the innate immune response, differs significantly between the two viruses, as is made clear by their impact on the temporal behavior of a number of measured genes. The model thus sheds light on the mechanisms that underlie the variability of innate immune responses to different H1N1 viruses.
Contributors
Submitter of the first revision: Miguel Fribourg
Submitter of this revision: Miguel Fribourg
Curator: Lucian Smith
Modeller: Miguel Fribourg
Submitter of this revision: Miguel Fribourg
Curator: Lucian Smith
Modeller: Miguel Fribourg
Metadata information
Curation status
Curated
Modelling approach(es)
Connected external resources
OmicsDI Impact Metrics
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Model files (1) |
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BIOMD0000000529.xml.origin | SBML L2V4 representation of Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99) | 65.05 KB | Preview | Download |
- Model originally submitted by : Miguel Fribourg
- Submitted: Mar 31, 2014 8:12:51 PM
- Last Modified: Aug 21, 2024 10:46:49 PM
Revisions
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Version: 3
- Submitted on: Aug 21, 2024 10:46:49 PM
- Submitted by: Lucian Smith
- With comment: CRBM-sponsored manual and automated updates.
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Version: 2
- Submitted on: Feb 24, 2015 8:30:54 PM
- Submitted by: Miguel Fribourg
- With comment: Current version of Fribourg2014 - Dynamics of viral antagonism and innate immune response (H1N1 influenza A virus - NC/99)
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Version: 1
- Submitted on: Mar 31, 2014 8:12:51 PM
- Submitted by: Miguel Fribourg
- With comment: Original import of BIOMD0000000529.xml.origin
(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions of this model will only be shown to the submitter and their collaborators.
Curator's comment:
(added: 03 Apr 2014, 14:50:42, updated: 03 Apr 2014, 14:50:42)
(added: 03 Apr 2014, 14:50:42, updated: 03 Apr 2014, 14:50:42)
Figure 5B of the reference publication has been reproduced. The simulation was done using SBML odeSolver and the plot was generated using Gnuplot.