Peterson2010 - Integrated calcium homeostasis and bone remodelling

View the 2016-07 Model of the Month entry for this model

Model Identifier
BIOMD0000000613
Short description
<notes xmlns="http://www.sbml.org/sbml/level3/version1/core"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Peterson2010 - integrated calcium homeostasis and bone remodelling</div> <div class="dc:description"> </div> <div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/19732857" title="Access to this publication">A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling.</a> </div> <div class="bibo:authorList">Peterson MC, Riggs MM.</div> <div class="bibo:Journal">Bone 2010 Jan; 46(1): 49-63</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Bone biology is physiologically complex and intimately linked to calcium homeostasis. The literature provides a wealth of qualitative and/or quantitative descriptions of cellular mechanisms, bone dynamics, associated organ dynamics, related disease sequela, and results of therapeutic interventions. We present a physiologically based mathematical model of integrated calcium homeostasis and bone biology constructed from literature data. The model includes relevant cellular aspects with major controlling mechanisms for bone remodeling and calcium homeostasis and appropriately describes a broad range of clinical and therapeutic conditions. These include changes in plasma parathyroid hormone (PTH), calcitriol, calcium and phosphate (PO4), and bone-remodeling markers as manifested by hypoparathyroidism and hyperparathyroidism, renal insufficiency, daily PTH 1-34 administration, and receptor activator of NF-kappaB ligand (RANKL) inhibition. This model highlights the utility of systems approaches to physiologic modeling in the bone field. The presented bone and calcium homeostasis model provides an integrated mathematical construct to conduct hypothesis testing of influential system aspects, to visualize elements of this complex endocrine system, and to continue to build upon iteratively with the results of ongoing scientific research.</p> </div> </div> <div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/BIOMD0000000613">BIOMD0000000613</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p> </div> <div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p> </div> </body> </notes>
Format
SBML (L3V1)
Related Publication
  • A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling.
  • Mark C Peterson, Matthew M Riggs
  • Bone , 1/ 2010 , Volume 46 , Issue 1 , pages: 49-63 , PubMed ID: 19732857
Contributors
Submitter of the first revision: Vijayalakshmi Chelliah
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: Vijayalakshmi Chelliah, Krishna Kumar Tiwari

Metadata information

is (2 statements)
BioModels Database BIOMD0000000613
BioModels Database MODEL1604270004

isDescribedBy (1 statement)
PubMed 19732857

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (3 statements)
hasProperty (3 statements)
Human Disease Ontology hypoparathyroidism
Human Disease Ontology hyperparathyroidism
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources