Yan2012 - Rb-E2F pathway dynamics with miR449

Model Identifier
BIOMD0000000720
Short description
MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback loops in the regulation of Rb-E2F pathway are predicted and shown experimentally. Recently, it has been discovered that E2F induce a cluster of miRNAs called miR449. In turn, E2F is inhibited by miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network. Here, based on the integration of experimental evidence and quantitative data, we studied Rb-E2F pathway coupling the positive feedback loops and negative feedback loops mediated by miR449. Therefore, a mathematical model is constructed based in part on the model proposed in Yao-Lee et al. (2008) and nonlinear dynamical behaviors including the stability and bifurcations of the model are discussed.
Format
SBML (L2V4)
Related Publication
  • Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449.
  • Fang Yan, Haihong Liu, Junjun Hao, Zengrong Liu
  • PloS one , 0/ 2012 , Volume 7 , Issue 9 , pages: e43908 , PubMed ID: 23028477
Contributors
Submitter of the first revision: Ashley Xavier
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Ashley Xavier

Metadata information

is (2 statements)
BioModels Database BIOMD0000000720
BioModels Database MODEL1811080001

isDescribedBy (4 statements)
DOI 10.1371/journal.pone.0043908
PubMed 23028477
PubMed 23028477
BioModels Database BIOMD0000000318

isDerivedFrom (5 statements)
Taxonomy Mammalia
BioModels Database BIOMD0000000318
Gene Ontology cell cycle
Mathematical Modelling Ontology Ordinary differential equation model
Reactome G1/S Transition

hasTaxon (1 statement)
Taxonomy Mammalia

hasPart (1 statement)
Gene Ontology cell cycle

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

isPartOf (1 statement)
Reactome G1/S Transition

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources