Jarrah2014 - mathematical model of the immune response in muscle degeneration and subsequent regeneration in Duchenne muscular dystrophy in mdx mice

Model Identifier
BIOMD0000001015
Short description
Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD. During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process. For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described. In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes. Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared.
Format
SBML (L3V1)
Related Publication
  • A mathematical model of skeletal muscle disease and immune response in the mdx mouse.
  • Abdul Salam Jarrah, Filippo Castiglione, Nicholas P Evans, Robert W Grange, Reinhard Laubenbacher
  • BioMed research international , 0/ 2014 , Volume 2014 , pages: 871810 , PubMed ID: 25013809
Contributors
Submitter of the first revision: Kausthubh Ramachandran
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Kausthubh Ramachandran

Metadata information

is (4 statements)
BioModels Database BIOMD0000001015
NCIt Immune Response Process
Mathematical Modelling Ontology Ordinary differential equation model
BioModels Database MODEL2107200002

isDescribedBy (1 statement)
PubMed 25013809

hasTaxon (1 statement)
Taxonomy Mus musculus

hasProperty (3 statements)
hasVersion (1 statement)
OMIT 0018341

occursIn (1 statement)

Curation status
Curated


Connected external resources