Uhlén2015 - Human tissue-based proteome metabolic network - bone marrow

Model Identifier
MODEL1411240003
Short description
Uhlén2015 - Human tissue-based proteome metabolic network - bone marrow
Human bone marrow tissue specific proteome metabolic network

This model is described in the article:

Tissue-based map of the human proteome
Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edllund K, Lundberg E, Navani S, Szigyarto AC, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P, Berlin H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Science 2015 January; 347(6220)

Abstract:

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray–based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.

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Format
SBML (L2V3)
Related Publication
  • Proteomics. Tissue-based map of the human proteome.
  • Uhlen M, Linn Fagerberg, Björn M Hallström, Lindskog C, Per Oksvold, Adil Mardinoglu, Åsa Sivertsson, Caroline Kampf, Evelina Sjöstedt, Anna Asplund, IngMarie Olsson, Karolina Edlund, Emma Lundberg, Sanjay Navani, Cristina Al-Khalili Szigyarto, Jacob Odeberg, Dijana Djureinovic, Jenny Ottosson Takanen, Sophia Hober, Tove Alm, Per-Henrik Edqvist, Holger Berling, Hanna Tegel, Jan Mulder, Johan Rockberg, Peter Nilsson, Schwenk JM, Marica Hamsten, Kalle von Feilitzen, Mattias Forsberg, Lukas Persson, Fredric Johansson, Martin Zwahlen, Gunnar von Heijne, Jens Nielsen, Fredrik Pontén
  • Science (New York, N.Y.) , 1/ 2015 , Volume 347 , Issue 6220 , pages: 1260419 , PubMed ID: 25613900
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu
Modeller: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1411240003

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
occursIn (1 statement)
Brenda Tissue Ontology bone marrow

Curation status
Non-curated

Connected external resources