Grigolon2018-Responses to auxin signals

Model Identifier
BIOMD0000000927
Short description 
Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the signal) on the auxin response factor (ARF) transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signalling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative feedback allows the system to have a far larger sensitivity in its dynamical response to auxin and that this sensitivity does not prevent the system from being highly resilient. Given this insight, we build a new biomolecular signalling model for quantitatively describing such Aux/IAA and ARF responses.
Format
SBML (L2V4)
Related Publication
  • Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience.
  • S Grigolon, B Bravi, O C Martin
  • Royal Society open science , 1/ 2018 , Volume 5 , Issue 1 , pages: 172098 , PubMed ID: 29410878
Contributors
Submitter of the first revision: Barbara Bravi
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: Tung Nguyen, Barbara Bravi, Ahmad Zyoud

Metadata information

is (2 statements)
BioModels Database BIOMD0000000927
BioModels Database MODEL1706070000

isDescribedBy (2 statements)
PubMed 29410878
PubMed 29410878

hasTaxon (1 statement)
hasProperty (3 statements)
occursIn (1 statement)
Brenda Tissue Ontology plant

Curation status
Curated
Modelling approach(es)
ordinary differential equation model

Connected external resources