Sier2017_estrogen_PBPK_GSMN

Model Identifier
MODEL1711210003
Short description
Physiologically-based Pharmacokinetic (PBPK) model of estradiol disposition in humans. Based on Sier et al_2017_estrogen PBPK_simple (MODEL1711210001), but with intrinsic (i.e. liver-mediated) clearance term replaced by a genome scale metabolic network. Extrahepatic clearance is still represented by as simple mass action Model was developed in the Multi-Formalism Interaction Network Simulator (MuFINS), as described in Wu et al 2017 (doi: 10.1038/npjsba.2016.32). relevant Software and tutorials can be found at http://sysbio3.fhms.surrey.ac.uk/mufins/
Format
SBML (L2V4)
Related Publication
  • Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology.
  • Joanna H Sier, Alfred E. Thumser, Nick Plant
  • BMC systems biology , 12/ 2017 , Volume 11 , Issue 1 , pages: 141 , PubMed ID: 29246152
Contributors
Submitter of the first revision: Nick Plant
Submitter of this revision: Rahuman S Malik-Sheriff
Modellers: Nick Plant, Rahuman S Malik-Sheriff

Metadata information

is (1 statement)
BioModels Database MODEL1711210003

isDescribedBy (1 statement)
PubMed 29246152


Curation status
Non-curated

Connected external resources