CHEBI:143127 - PDGF receptor tyrosine kinase inhibitor III

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ChEBI Name PDGF receptor tyrosine kinase inhibitor III
ChEBI ID CHEBI:143127
Definition An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a (4-phenoxyphenyl)aminocarbonyl group, while the hydrogen attached to the nitrogen at position 4 is replaced by a 6,7-dimethoxyquinazolin-4-yl group. It is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Ceri
Supplier Information
Download Molfile XML SDF
Formula C27H27N5O4
Net Charge 0
Average Mass 485.544
Monoisotopic Mass 485.20630
InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
InChIKey INTPTKHSGKBHHW-UHFFFAOYSA-N
SMILES O=C(N1CCN(CC1)C2=NC=NC=3C2=CC(OC)=C(OC)C3)NC4=CC=C(OC5=CC=CC=C5)C=C4
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a N-arylpiperazine (CHEBI:46848)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a N-carbamoylpiperazine (CHEBI:46919)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a aromatic ether (CHEBI:35618)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a phenylureas (CHEBI:134043)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a quinazolines (CHEBI:38530)
PDGF receptor tyrosine kinase inhibitor III (CHEBI:143127) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide
Synonyms Sources
N-(4-phenoxyphenyl)-4-(6,7-dimethoxyquinazoline-4-yl)piperazine-1-carboxamide ChEBI
PDGFR tyrosine kinase inhibitor III ChEBI
Registry Number Type Source
205254-94-0 CAS Registry Number SUBMITTER
Citations Waiting for Citations Types Sources
12238930 PubMed citation Europe PMC
12941321 PubMed citation Europe PMC
Last Modified
21 February 2019