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temozolomide |
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CHEBI:72564 |
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An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma. |
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This entity has been manually annotated by the ChEBI Team.
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Molfile
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SDF
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InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
BPEGJWRSRHCHSN-UHFFFAOYSA-N |
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alkylating agent
Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
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View more via ChEBI Ontology
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
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temozolomida
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WHO MedNet
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témozolomide
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WHO MedNet
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temozolomide
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ChemIDplus
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temozolomidum
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WHO MedNet
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3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
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ChemIDplus
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3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
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ChemIDplus
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3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
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ChemIDplus
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8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
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ChemIDplus
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BRN 5547136
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ChemIDplus
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CCRG 81045
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ChemIDplus
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CCRG-81045
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ChemIDplus
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CCRIS 8996
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ChemIDplus
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M & B 39831
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ChemIDplus
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MB 39831
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ChemIDplus
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M&B 39831
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ChemIDplus
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methazolastone
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ChemIDplus
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NSC 362856
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ChemIDplus
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Sch 52365
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ChemIDplus
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TMZ
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ChEBI
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Temodal
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KEGG DRUG
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Temodar
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ChEBI
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5547136
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Reaxys Registry Number
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Reaxys
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85622-93-1
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CAS Registry Number
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ChemIDplus
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22680781
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PubMed citation
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Europe PMC
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22818211
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PubMed citation
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Europe PMC
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23246370
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PubMed citation
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Europe PMC
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23254891
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PubMed citation
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Europe PMC
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23293540
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PubMed citation
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Europe PMC
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23335050
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PubMed citation
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Europe PMC
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23362460
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PubMed citation
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Europe PMC
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23377829
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PubMed citation
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Europe PMC
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23385995
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PubMed citation
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Europe PMC
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23389760
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PubMed citation
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Europe PMC
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