CHEBI:67271 - MK-2206

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ChEBI Name MK-2206
ChEBI ID CHEBI:67271
Definition An organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted by 4-(1-aminocyclobutyl)phenyl and phenyl groups at positions 8 and 9, respectively. It is an allosteric Akt inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C25H21N5O
Net Charge 0
Average Mass 407.46710
Monoisotopic Mass 407.17461
InChI InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)
InChIKey ULDXWLCXEDXJGE-UHFFFAOYSA-N
SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): autophagy inducer
Any compound that induces the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing MK-2206 (CHEBI:67271) has role antineoplastic agent (CHEBI:35610)
MK-2206 (CHEBI:67271) has role apoptosis inducer (CHEBI:68495)
MK-2206 (CHEBI:67271) has role autophagy inducer (CHEBI:138880)
MK-2206 (CHEBI:67271) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
MK-2206 (CHEBI:67271) is a benzenes (CHEBI:22712)
MK-2206 (CHEBI:67271) is a cyclobutanes (CHEBI:156473)
MK-2206 (CHEBI:67271) is a organic heterotricyclic compound (CHEBI:26979)
MK-2206 (CHEBI:67271) is a primary amino compound (CHEBI:50994)
IUPAC Name
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
Synonyms Sources
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one ChEBI
MK 2206 ChEBI
MK-2206 free base DrugBank
MK2206 ChEBI
Manual Xrefs Databases
DB16828 DrugBank
LSM-1057 LINCS
MK-2206 Wikipedia
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Registry Numbers Types Sources
1032349-93-1 CAS Registry Number ChEBI
18391321 Reaxys Registry Number Reaxys
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Last Modified
02 September 2024