InChI=1S/C17H14O7S/c1-23-17(21)15-12(25(2)22)4-3-10-14(15)16(20)13-9(19)5-8(7-18)6-11(13)24-10/h3-6,18-19H,7H2,1-2H3 |
AYCYZLASDOHFHP-UHFFFAOYSA-N |
COC(=O)C1=C(C=CC2=C1C(=O)C1=C(O2)C=C(CO)C=C1O)S(C)=O |
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Aspergillus sp. SCSIO Ind09F01
(NCBI:txid1654592)
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See:
PubMed
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Aspergillus metabolite
Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus .
marine metabolite
Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
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View more via ChEBI Ontology
methyl 8-hydroxy-6-(hydroxymethyl)-2-(methylsulfinyl)-9-oxo-9H-xanthene-1-carboxylate
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methyl 8-hydroxy-6-(hydroxymethyl)-2-(methanesulfinyl)-9-oxo-9H-xanthene-1-carboxylate
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IUPAC
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Zhang X, Li SJ, Li JJ, Liang ZZ, Zhao CQ (2018) Novel Natural Products from Extremophilic Fungi. Marine drugs 16, E194 [PubMed:29867059] [show Abstract] Extremophilic fungi have been found to develop unique defences to survive extremes of pressure, temperature, salinity, desiccation, and pH, leading to the biosynthesis of novel natural products with diverse biological activities. The present review focuses on new extremophilic fungal natural products published from 2005 to 2017, highlighting the chemical structures and their biological potential. | Tian Y, Qin X, Lin X, Kaliyaperumal K, Zhou X, Liu J, Ju Z, Tu Z, Liu Y (2015) Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The Journal of antibiotics 68, 703-706 [PubMed:25944530] [show Abstract] A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against HeLa, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 μM, respectively. |
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