CHEBI:229781 - WZB-117

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ChEBI Name WZB-117
ChEBI ID CHEBI:229781
Definition A diester resulting from the formal condensation of the two hydroxy groups of 3-fluorocatechol with the carboxy groups of 3-hydroxybenzoic acid. It is an inhibitor of glucose transporter 1 (GLUT1) that suppresses tumour growth in mouse xenograft models.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Doug Howe
Supplier Information
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Roles Classification
Biological Role(s): glucose transporter 1 inhibitor
Any glucose transporter inhibitor that interferes with the action of glucose transporter 1.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
radiosensitizing agent
A drug that makes increases the sensitivity of tumour cells to radiation therapy.
Related Structures
WZB-117 is a Structural Derivative of
3-hydroxybenzoic acid
Mass : 138.12074
Formula : C7H6O3
30764 		3-fluorocatechol
Mass : 128.10110
Formula : C6H5FO2
39876 		benzoic acids
Definition : Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.
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